Abstract:
:This case-control study was carried out to investigate the possible relationship between the gene frequencies of HLA-DRB1, -DQA1 and -DQB1 alleles/haplotypes and rheumatic heart disease (RHD) among the Chinese population in Taiwan. A group of 115 patients with RHD documented by echocardiography, and a group of 115 normal controls were studied. The HLA-DRB1, -DQA1 and -DQB1 allele frequencies were determined by polymerase chain reaction and sequence-specific oligonucleotide probe. As compared with controls, patients with RHD had an increased frequency of DR11-05-DQ7 haplotype and a decreased frequency of DR4-03-DQ4 haplotype. The frequencies of DRB1, DQA1 or DQB1 alleles were not significantly different between RHD patients and controls. Further categorization of RHD patients into mitral valve disease and combined valve disease subgroups revealed no statistical difference in these alleles when compared with the two subgroups. Patients with RHD have a higher frequency of DR11-05-DQ7 haplotype and a lower frequency of DR4-03-DQ4 haplotype, which indicates that certain HLA DRB1-DQA1-DQB1 haplotypes in determining the risk/protection of RHD in Taiwan Chinese.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Chou HT,Chen CH,Chen JY,Chang KCdoi
10.1016/j.ijcard.2007.06.032subject
Has Abstractpub_date
2008-08-29 00:00:00pages
434-5issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(07)01213-2journal_volume
128pub_type
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(95)02393-b
更新日期:1995-08-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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journal_title:International journal of cardiology
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更新日期:2017-04-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
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更新日期:2011-01-07 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2008-04-25 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
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更新日期:2017-08-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1987-10-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2012.04.003
更新日期:2013-06-05 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2007-08-09 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2011-10-06 00:00:00
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journal_title:International journal of cardiology
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更新日期:2017-10-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2007-03-02 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2008-08-29 00:00:00
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pub_type: 杂志文章
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更新日期:1992-03-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(95)02367-6
更新日期:1995-06-30 00:00:00
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journal_title:International journal of cardiology
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更新日期:2009-11-12 00:00:00
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更新日期:2020-10-01 00:00:00
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journal_title:International journal of cardiology
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更新日期:2018-06-15 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2016-11-15 00:00:00
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更新日期:2015-03-01 00:00:00
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更新日期:2008-11-12 00:00:00
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pub_type: 信件,随机对照试验
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2006-10-26 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2007-08-21 00:00:00