Abstract:
PURPOSE:To evaluate the short-term efficacy and safety of intravitreal bevacizumab in myopic choroidal neovascularization (mCNV). METHODS:In this noncomparative, consecutive, interventional case series, 12 eyes of 11 patients with mCNV without any previous treatment were included. Patients received intravitreal bevacizumab (1.25 mg/0.05 mL) at baseline and at 4 weeks interval, if optical coherence tomography (OCT) showed presence of intraretinal edema, subretinal fluid, and/or pigment epithelial detachment. Patients were followed up for a minimum of 6 months and changes in best-corrected visual acuity, central macular thickness (CMT) on OCT, angiographic characteristics, and complications were assessed. RESULTS:The mean refractive error was -11.25 diopters. At 6 months the mean best-corrected visual acuity (BCVA) improved from 20/235 (median 20/235) to 20/71 (median 20/80) (p=0.01). The mean CMT was reduced from 403 microm (median 365 microm) to 229 microm (median 239 microm) (p=0.002). At final visit 9 eyes (75%) had an improvement of BCVA of three lines or more, and only 1 eye (8%) lost two lines. No significant ocular or untoward systemic side effects were observed. CONCLUSIONS:In this small series short-term results suggest that intravitreal bevacizumab (1.25 mg/0.05 mL) is safe, effective, and well tolerated in patients with choroidal neovascularization due to high myopia. Further evaluation in large series with longer follow-up is needed to confirm long-term efficacy and safety in such cases.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Mandal S,Venkatesh P,Sampangi R,Garg Sdoi
10.1177/112067210701700422subject
Has Abstractpub_date
2007-07-01 00:00:00pages
620-6issue
4eissn
1120-6721issn
1724-6016journal_volume
17pub_type
临床试验,杂志文章abstract:PURPOSE:To evaluate the intermediate-term efficacy and safety of micropulsed diode laser cyclophotocoagulation in recurrent pediatric glaucoma. PATIENTS AND METHODS:A prospective interventional study included children <16 years old diagnosed with recurrent glaucoma, attending Mansoura University, during the period fro...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119858226
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:Among the 500 ABCA4 mutations identified so far in the retina-specific ABC transporter (ABCA4) gene, only 20 have been described in patients with autosomal recessive retinitis pigmentosa (arRP). In this study the gene was screened for mutations in a cohort of 25 patients of Spanish origin, to further assess ABC...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700510
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:Characterize the safety and tolerability of lifitegrast ophthalmic solution 5.0% for the treatment of dry eye disease. METHODS:Pooled data from five randomized controlled trials were analyzed. Key inclusion criteria were adults with dry eye disease (Schirmer tear test score ⩾1 and ⩽10 mm, eye dryness score ⩾40...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1120672118791936
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To evaluate central macular thickness (CMT) after cataract surgery in selected groups of patients. METHODS:The study comprised 4 groups-patients with epiretinal membrane, patients with high myopia, patients with diabetes without retinopathy, and healthy subjects-who underwent phacoemulsification and intraocu...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000280
更新日期:2013-09-01 00:00:00
abstract:PURPOSE::To evaluate the predictive value of magnetic resonance imaging in retinoblastoma for the likelihood of high-risk pathologic features. METHODS::A retrospective study of 64 eyes enucleated from 60 retinoblastoma patients. Contrast-enhanced magnetic resonance imaging was performed before enucleation. Main outcom...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118781200
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:Ocular toxoplasmosis is associated with vitreoretinal complications that can potentially cause severe visual loss. The aim of this study is to report the preoperative, intraoperative, and postoperative outcomes of vitreous surgery in eyes with vitreoretinal complications secondary to ocular toxoplasmosis. METH...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE OF THE STUDY:Inborn lens opacity is the most frequent cause of childhood blindness. In this study, we aimed to define the presumed genetic cause of a congenital cataract present in a Mauritanian family over the last nine generations. METHODS:A family history of the disease and eye examination were carried ou...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118804757
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:To check whether three months' follow-up is sufficient to determine endothelial cell loss after cataract surgery and whether this value depends on preoperative central endothelial cell density. METHODS:A two-year prospective assessment of central endothelial cell density was done in 60 eyes after phacoemulsifi...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210201200106
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:To study the impact of ocular hypotensive lipids (OHL) on the incidence, progression, and response to treatment of clinically significant diabetic macular edema (CSDME). METHODS:A total of 379 patients (232 female, 147 male) with a history of diabetes mellitus (DM) and primary open-angle glaucoma (POAG) were i...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000109
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To describe the in vivo confocal microscopy corneal findings in a patient treated with gold sodium thiomalate. METHODS:A woman with rheumatoid arthritis who had been treated with gold sodium thiomalate for 32 years came to our center for an ophthalmologic examination about 5 years ago. Besides visual acuity, t...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000421
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:To investigate the low mesopic contrast sensitivity function (LMCSF) of patients implanted with different modern optical bifocal and trifocal designs of multifocal intraocular lenses (mfIOLs). METHODS:This prospective, comparative, nonrandomized consecutive case series included 180 eyes that underwent cataract...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000777
更新日期:2016-11-04 00:00:00
abstract:PURPOSE:To evaluate the effect on lacrimal function and ocular complications in patients with severe acne vulgaris during systemic treatment with 13-cis-retinoic acid (isotretinoin). METHODS:Forty patients with acne vulgaris were treated with systemic isotretinoin at dosages of 0.5-1 mg/kg per day for two months. Full...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract::Strabismus fixus is a rare condition and usually is of convergent type in which one or both eyes are anchored in a position of extreme adduction. Convergent type strabismus fixus is considered to be a congenital disorder and a part of congenital extraocular muscle fibrosis syndrome. Villasecca and Martinez described a...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210301300214
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To report fixation stability changes in patients with different forms of infantile nystagmus syndrome (INS), who have undergone a visual rehabilitation through biofeedback fixation training (BFT) with microperimetry (MP). DESIGN:Retrospective study. METHODS:Patients 6 to 12 years-old with INS who performed ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120940981
更新日期:2020-07-06 00:00:00
abstract::The two most frequent sites of obstruction of the lacrimal pathways are under the lacrimal sac, in the ductus lacrimonasalis, and over the lacrimal sac, in the canaliculi. The obstruction of the first type already has a satisfactory solution with the different forms of dacryo-cysto-rhinostomies. Obstruction of the sec...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::A 50-year-old white man complained of "inflammation" of his right eyelid since January 1989. In June 1990, he had undergone a gastrectomy for an adenocarcinoma of the stomach. In August 1990, his right eye showed a painless, firm infiltration of the upper and lower lid, ulceration and loss of eyelashes of the upper li...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:To compare 4 limbal-conjunctival autograft fixation techniques-conventional suture, commercial fibrin glue, autologous fibrin glue, and cautery-in primary nasal pterygium surgery. METHODS:This is a retrospective and descriptive study. The postoperative patient discomfort, graft edema, ocular inflammation, and ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000924
更新日期:2017-06-26 00:00:00
abstract:PURPOSE:To evaluate epithelial healing and visual outcome after laser-assisted subepithelial keratectomy (LASEK) without alcohol de-epithelialization and to compare this technique to photorefractive keratectomy (PRK) in myopia. METHODS:In a series of 1953 patients undergoing bilateral myopic PRK, an epithelial flap co...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1177/112067210301300802
更新日期:2003-10-01 00:00:00
abstract:PURPOSE:A prospective, open-label study in 20 professional swimmers evaluated the efficacy and safety of an ophthalmic solution containing crosslinked hyaluronic acid, coenzyme Q10, and vitamin E TPGS in releasing eye irritation and restoring ocular surface damages after prolonged exposure to chlorinated water. METHOD...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120907311
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:Polymethylmethacrylate (PMMA) segments are normally used in additive surgery to treat both corneal ectasia post laser-assisted in situ keratomileusis and keratoconus. The aim of this work was to develop an experimental animal model to induce wound healing in the deep stroma in corneas of hens. METHODS:PMMA seg...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000108
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy, safety, and tolerability of Timogel® preservative-free once daily compared to timolol 0.5% ophthalmic solution bid in patients with ocular hypertension (OHT) and patients with primary open-angle glaucoma (POAG). METHODS:A total of 75 patients with OHT and patients with POAG treated wi...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000006
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To investigate color perception and contrast sensitivity with and without additional glare in pseudophakic patients with a conventional intraocular lens (IOL) in one eye and a blue light-filtering IOL in the fellow eye. METHODS:Twenty-three bilaterally pseudophakic patients with a conventional IOL (AcrySof SA6...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900210
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to assess indications and outcome of carotid Doppler ultrasound requested by ophthalmologists from an eye hospital over a period of three years. METHODS:This retrospective study was designed to analyse data for all patients referred to have carotid Doppler ultrasound from 1999 to ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract:PURPOSE:Leber hereditary optic neuropathy (LHON) is recognized as the most common cause of isolated blindness in young men. The current study was designed to test whether LHON as a mitochondrial disease is associated with vascular functional alterations characterized by aortic elastic properties during echocardiography...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210801800225
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To report clinical findings and surgical management of 4 patients with congenital nystagmus who presented with a new or reversal of their original horizontal compensatory head posture (CHP) after Anderson-Kestenbaum (A-K) surgery. METHOD:Retrospective chart review. RESULTS:All 4 patients demonstrated a 40°-45...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2011.8356
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:The aim of this study is to evaluate the incidence, natural course, and distribution pattern of superficial punctate keratopathy and describe the changes in signs and symptoms of dry eye after cataract surgery. SETTING:The setting of this study is University Hospital Rio Hortega and Instituto Universitario de ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119896427
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To report a case of late onset posttraumatic endophthalmitis secondary to Propionibacterium acnes infection. METHODS:Interventional case report. RESULTS:A 28-year-old man developed endophthalmitis 6 months after a penetrating trauma. The patient underwent pars plana lensectomy and vitrectomy along with inject...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2008.3552
更新日期:2004-01-01 00:00:00
abstract:SIGNIFICANCE:Susac's syndrome is a rare retinocochleocerebral immune-mediated endotheliopathy and clinically manifests as a pathognomonic triad of encephalopathy, hearing loss, and branch retinal artery occlusion. This triad is rarely present at symptom onset, thus, it is often initially misdiagnosed. To date, Susac's ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120924545
更新日期:2020-05-07 00:00:00
abstract:PURPOSE:To evaluate the effect and safety of fovea-sparing internal limiting membrane (ILM) peeling (FSIP) for myopic traction maculopathy comparing with that of total ILM peeling (TP). METHODS:PubMed, Web of science, Embase, Cochrane, EBSCO and CNKI, published until January 2020, were searched. Postoperative best-cor...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120970111
更新日期:2020-11-03 00:00:00
abstract:PURPOSE:To report a real-life experience with the Argus II retinal prosthesis system in blind patients with end-stage retinitis pigmentosa (RP) or choroideremia (CHM), focusing on the pivotal role of optical coherence tomography (OCT) in both preoperative and postoperative management. METHODS:This hospital-based case ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000852
更新日期:2017-01-19 00:00:00