Progress in computational protein design.

Abstract:

:Current progress in computational structure-based protein design is reviewed in the areas of methodology and applications. Foundational advances include new potential functions, more efficient ways of computing energetics, flexible treatments of solvent, and useful energy function approximations, as well as ensemble-based approaches to scoring designs for inclusion of entropic effects, improvements to guaranteed and to stochastic search techniques, and methods to design combinatorial libraries for screening and selection. Applications include new approaches and successes in the design of specificity for protein folding, binding, and catalysis, in the redesign of proteins for enhanced binding affinity, and in the application of design technology to study and alter enzyme catalysis. Computational protein design continues to mature and advance.

journal_name

Curr Opin Biotechnol

authors

Lippow SM,Tidor B

doi

10.1016/j.copbio.2007.04.009

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

305-11

issue

4

eissn

0958-1669

issn

1879-0429

pii

S0958-1669(07)00077-8

journal_volume

18

pub_type

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