Molecular design of anti-MRSA agents based on the anacardic acid scaffold.

Abstract:

:A series of anacardic acid analogues possessing different side chains viz. phenolic, branched, and alicyclic were synthesized and their antibacterial activity tested against methicillin-resistant Staphylococcus aureus (MRSA). The maximum activity against this bacterium occurred with the branched side-chain analogue, 6-(4',8'-dimethylnonyl)salicylic acid, and the alicyclic side-chain analogue, 6-cyclododecylmethyl salicylic acid, with the minimum inhibitory concentration (MIC) of 0.39 microg/mL, respectively. This activity was superior to that of the most potent antibacterial anacardic acid isolated from the cashew Anacardium occidentale (Anacardiaceae), apple and nut, that is, the 6-[8'(Z),11'(Z),14'-pentadecatrienyl]salicylic acid.

journal_name

Bioorg Med Chem

authors

Green IR,Tocoli FE,Lee SH,Nihei K,Kubo I

doi

10.1016/j.bmc.2007.06.022

subject

Has Abstract

pub_date

2007-09-15 00:00:00

pages

6236-41

issue

18

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)00545-7

journal_volume

15

pub_type

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