Abstract:
:Microdialysis enables the chemistry of extracellular fluid in body tissues to be measured. Extracellular proteases such as the cysteine protease, cathepsin S (CatS), are thought to facilitate astrocytoma invasion. Microdialysates obtained from human brain tumours in vivo were subjected to cathepsin S activity and ELISA assays. Cathepsin S ELISA expression was detected in five out of 10 tumour microdialysates, while activity was detected in five out of 11 tumour microdialysates. Cathepsin S expression was also detected in microdialysate from the normal brain control although no activity was found in the same sample. While some refinements to the technique are necessary, the authors demonstrate the feasibility and safety of microdialysis in human astrocytomas in vivo. Characterisation of the extracellular environment of brain tumours in vivo using microdialysis may be a useful tool to identify the protease profile of brain tumours.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Flannery T,McConnell RS,McQuaid S,McGregor G,Mirakhur M,Martin L,Scott C,Burden R,Walker B,McGoohan C,Johnston PGdoi
10.1080/02688690701248190subject
Has Abstractpub_date
2007-04-01 00:00:00pages
204-9issue
2eissn
0268-8697issn
1360-046Xpii
777021244journal_volume
21pub_type
临床试验,杂志文章abstract::Our aim is to present a typical case of IgG4-related hypophysitis, which will offer insight into the aetiology and pathogenesis of this relatively newly described disease. IgG4 Related Disease is a protean systemic condition that mimics inflammatory, infectious, and malignant processes. Biopsy of affected organs will ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2017.1416061
更新日期:2020-02-01 00:00:00
abstract::We report the case of a 32-year-old woman with a left frontal ganglioglioma (WHO grade I). Quantitative analysis based on three dimensional magnetic resonance images revealed a threefold increase of growth rate during pregnancy as compared to pre-pregnancy, causing neurological deterioration and leading to prompt surg...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2012.703356
更新日期:2013-02-01 00:00:00
abstract::Purpose: The purpose of this study was to validate the cauda scale (TCS) in an external population. TCS was proposed as a tool to be used to predict the likelihood of cauda equina compression.Methods: We analysed the presenting condition of consecutive patients attending the emergency department undergoing a magnetic ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1754337
更新日期:2020-08-01 00:00:00
abstract::Chiari malformations are a pathological continuum of hindbrain maldevelopment and Chiari I malformation (CMI) represents caudal decent of cerebellar tonsils. The surgery aims to relieve tonsillar compression with restoration of the normal cerebrospinal (CSF) flow dynamics. We report the salient features of our surgica...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690801894638
更新日期:2008-06-01 00:00:00
abstract::Cavernous angiomas affecting the optic pathway are rare. This report describes the case of a 12-year-old girl who presented with a 10-month history of right-sided blurred vision caused by a cavernous angioma affecting the right side of the optic chiasm. The computed tomography (CT) scan demonstrated a hyperdense image...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688697.2012.685820
更新日期:2012-12-01 00:00:00
abstract::Cerebrospinal fluid (CSF) fistulae almost invariably lead to meningitis, even in the absence of other clinically obvious sequelae of the fistula such as a CSF fluid leak. The only effective means of reducing the risk of meningitis is surgical closure of the fistula. If surgery is to be recommended to patients with CSF...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699745646
更新日期:1997-12-01 00:00:00
abstract::We report our experience with five lesions exclusively involving the entire cavernous sinus in which an essentially extradural surgical approach was used. There were two cases of cavernous haemangioma, two cases of meningioma and one case of fungal granuloma. The dural cover of the superior orbital fissure, and mandib...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699746483
更新日期:1997-04-01 00:00:00
abstract::A 34-year-old male sustained a unilateral avulsion fracture through the origin of the transverse atlantal ligament following a road traffic accident. This was successfully treated in a rigid neck collar for 8 weeks. Injuries to the transverse atlantal ligament are often associated with significant bony injury and atla...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690400005164
更新日期:2004-08-01 00:00:00
abstract::Subarachnoid hemorrhage with ruptured cerebral artery dissection caused by varicella zoster (VZ) vasculopathy is rare. We report a rare case of vertebral artery (VA) dissection induced by VZ virus, successfully treated with stent-assisted coil embolization and systemic anti viral medication, on six month follow-up cer...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2016.1187256
更新日期:2016-12-01 00:00:00
abstract::The objective of the investigation was to report on the health-related quality of life (HRQoL) of patients diagnosed with skull base tumours using the Short Form Health Survey questionnaire (SF-36). Those patients suffering with vestibular schwannoma were examined to determine the effect facial nerve function had on t...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690120114183
更新日期:2002-02-01 00:00:00
abstract::Interstitial brachytherapy for recurrent gliomas normally necessitates the invasive application of a stereotactic frame by screw-fixation which must be kept on for several hours. The use of a relocatable stereotactic frame offers many advantages over conventional systems. We present our experience in 18 patients and v...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699209002371
更新日期:1992-01-01 00:00:00
abstract::Lumbar discal cysts are rare entities causing radicular pain with unknown etiologies. We report a case of a 42-year-old man who developed radiculopathy secondary to a lumbar discal cyst. Our case sheds some light on anatomy, possible etiological association and clinical course which can help management. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2015.1100274
更新日期:2016-12-01 00:00:00
abstract::Laser angioplasty is used to vaporize atheroma in limb arteries. The present investigation was undertaken to determine the nature, size and quantity of particulate matter generated, and the appearance of the intima of a carotid artery model after laser treatment. Particulate matter was not significantly increased foll...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699108998443
更新日期:1991-01-01 00:00:00
abstract::This study evaluated the clinical outcomes following venous ligation for the treatment of dural arteriovenous fistulas (DAVF) with leptomeningeal or cortical venous drainage. The authors conducted a single-centre, retrospective study of 15 patients with DAVF treated consecutively between 1990 and 2000. There were eigh...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/0268869031000153125
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Solitary Fibrous Tumour (SFT) is a rare tumour occurring mainly in the pleural cavity, with less than 100 cases reported in the Central Nervous System, where it typically presents as a meningeal-based lesion. We describe the case of a SFT located in the fourth ventricle and briefly review the pertinent liter...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688691003675226
更新日期:2010-08-01 00:00:00
abstract::The purpose of this article is to review the contribution of DSA to neurosurgical practice and to outline its advantages and limitations compared to conventional film-screen angiography. DSA is a technique whereby electronic subtraction allows the near instantaneous demonstration of vascular anatomy essentially free o...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698709023774
更新日期:1987-01-01 00:00:00
abstract::The effectiveness and safety of intraoperative magnetic resonance imaging (iMRI) are evident from many reports over the past decade. However, these reports have mainly concerned surgeries for glioma and other intra-axial tumours, and applications of this approach for extra-axial tumours are poorly documented. We retro...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1784844
更新日期:2020-06-26 00:00:00
abstract::In vestibular schwannomas (VS), the tumour size, as well as the size of the cystic component, have a considerable bearing on the outcome. This study addresses the differences between the cystic and solid variants of giant vestibular schwannomas. The study included 62 patients with giant VSs, of which 40 were solid and...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690802159031
更新日期:2008-08-01 00:00:00
abstract::Side-effects of iohexol myelography were compared after pre-treatment with oral dexamethasone (n = 42) or placebo (n = 44) in a prospective, randomized, double blind, controlled clinical trial. Although myelogram side-effects were commoner in the placebo group, the differences generally did not reach statistical signi...
journal_title:British journal of neurosurgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/02688699650040151
更新日期:1996-06-01 00:00:00
abstract::The authors report the rare and first documented case of concomitant microvascular decompression of trigeminal, facial and glossopharyngeal nerves for the management of intractable to medical therapy acute onset of trigeminal neuralgia, facial paresis and dysphagia after mild head injury. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2013.815327
更新日期:2014-01-01 00:00:00
abstract::Intracerebral haemorrhage is a devastating condition lacking effective therapies, with an uncertain role for surgery in many. Early research described an ischaemic penumbra around the haematoma, representing an area of potential therapeutic intervention. This article discusses the evidence for and against the existenc...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2011.578773
更新日期:2011-08-01 00:00:00
abstract::Cerebellar haemangioblastomas commonly arise in patients with von Hippel - Lindau disease. We present the case of a 47-year-old male who has successfully undergone 10 separate procedures for symptomatic cerebellar haemangioblastomas. To our knowledge, this case is unique with respect to the frequency of symptomatic re...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690701552864
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:Surgical manipulation of the pituitary stalk, neurohypophysis or the hypothalamus may disturb control of the plasma sodium level. The factors that might predict the risk of postoperative sodium imbalance are not clear, and were investigated in this study. METHODS:A retrospective survey of 129 surgical record...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2012.714013
更新日期:2013-02-01 00:00:00
abstract::The aim of this study was to evaluate guidance techniques and patient outcomes of ultrasound-guided neuronavigation of deep-seated intracerebral cavernous hemangiomas (CAs). Thirty-five patients with deep-seated intracerebral CAs with sizes ranging between 7 and 45 mm were operated upon only with ultrasound-guidance. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690120097714
更新日期:2001-12-01 00:00:00
abstract::We describe a patient who within 2 months of undergoing radio-chemotherapy for glioblastoma developed an Epstein-Barr virus-positive primary diffuse large B-cell CNS lymphoma. To our knowledge, this is the first such case reported in the literature showing that new tumefactions following aggressive treatment for gliob...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2013.829554
更新日期:2014-04-01 00:00:00
abstract::Twenty patients bearing malignant brain tumours (18 glioblastoma multiforme, one malignant meningioma, one melanoma metastasis) were treated 25 times with photodynamic therapy (PDT)--the combination of Hematoporophyrin derivative and light at 630 nm (40-120 J/cm2). Sixteen times the PDT was followed immediately by a s...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698808992675
更新日期:1988-01-01 00:00:00
abstract::The Internet is a global computer network which has recently become accessible for many reasons to the general public. The growth in its use for entertainment purposes is now being mirrored by its application to medical interests requiring rapid communication. Neurosurgery as a speciality has a tradition of adapting q...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699646853
更新日期:1996-12-01 00:00:00
abstract::A case of primary Ewing's sarcoma involving a large portion of the petrous temporal bone in an eighteen month old child is reported. The lesion was treated by radical surgery and adjuvant chemotherapy and radiotherapy. An extremely rare age of presentation, an unusual location and an excellent response to treatment ar...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.1080/02688690050004606
更新日期:2000-04-01 00:00:00
abstract::We present our experience with suprabow minicraniotomy in the excision of 18 suprasellar tumours between May 2001 and September 2003. There were 14 females and four males with ages ranging from 7 to 59 years. The tumours included one epidermoid cyst, 10 meningiomas, five craniopharyngiomas and two optico-chiasmatico-h...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690500089415
更新日期:2005-02-01 00:00:00
abstract::Intraparenchymal meningiomas are rare. To date, no such lesion has been reported within the basal ganglia of a paediatric patient. Here, we describe the case of a 15-year-old-boy who presented with symptoms referable to a cystic, calcified, left basal ganglia intraparenchymal meningioma and discuss the surgical manage...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2015.1096910
更新日期:2016-06-01 00:00:00