Abstract:
BACKGROUND:Different drugs have been used to enhance postoperative neuraxial opioid analgesia and reduce adverse effects. METHODS:We randomized 60 patients into 2 groups to receive either 2 mL saline or 0.1 mg/kg dexamethasone IV before the administration of intrathecal anesthesia (15 mg and meperidine 15 mg). After surgery, patients were asked to score their pain at 6, 12, 18, and 24 h. The presence of postoperative nausea and vomiting (PONV), pruritus and respiratory depression were recorded. RESULTS:The total dose of diclofenac (P < 0.05), visual analog scale pain score at 6-h intervals (P < 0.001), and the incidence of PONV (P < 0.05) were significantly lower in the dexamethasone group. CONCLUSIONS:Administration of IV dexamethasone prior to intrathecal meperidine injection enhances analgesia and reduces PONV.
journal_name
Anesth Analgjournal_title
Anesthesia and analgesiaauthors
Movafegh A,Soroush AR,Navi A,Sadeghi M,Esfehani F,Akbarian-Tefaghi Ndoi
10.1213/01.ane.0000257926.07491.55subject
Has Abstractpub_date
2007-04-01 00:00:00pages
987-9issue
4eissn
0003-2999issn
1526-7598pii
104/4/987journal_volume
104pub_type
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