The effect of intravenous administration of dexamethasone on postoperative pain, nausea, and vomiting after intrathecal injection of meperidine.

Abstract:

BACKGROUND:Different drugs have been used to enhance postoperative neuraxial opioid analgesia and reduce adverse effects. METHODS:We randomized 60 patients into 2 groups to receive either 2 mL saline or 0.1 mg/kg dexamethasone IV before the administration of intrathecal anesthesia (15 mg and meperidine 15 mg). After surgery, patients were asked to score their pain at 6, 12, 18, and 24 h. The presence of postoperative nausea and vomiting (PONV), pruritus and respiratory depression were recorded. RESULTS:The total dose of diclofenac (P < 0.05), visual analog scale pain score at 6-h intervals (P < 0.001), and the incidence of PONV (P < 0.05) were significantly lower in the dexamethasone group. CONCLUSIONS:Administration of IV dexamethasone prior to intrathecal meperidine injection enhances analgesia and reduces PONV.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Movafegh A,Soroush AR,Navi A,Sadeghi M,Esfehani F,Akbarian-Tefaghi N

doi

10.1213/01.ane.0000257926.07491.55

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

987-9

issue

4

eissn

0003-2999

issn

1526-7598

pii

104/4/987

journal_volume

104

pub_type

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