Abstract：
PURPOSE:Several studies have reported significant renal toxicity after the use of a high dose of 90Y-DOTATOC. Thus, renal protection is necessary in treatments with 90Y-DOTA Tyr3-octreotide (DOTATOC). The infusion of certain positively charged amino acids has been shown to effectively reduce renal uptake of DOTATOC. In this study, we compared the effectiveness of three kinds of amino acids, D-lysine (lysine), L-arginine (arginine) and histidine, on renal protection in healthy rats and tried to determine which one was the most effective. METHODS:Twenty SD healthy male rats were divided into 4 groups: lysine, histidine, arginine, and control. The rats were injected with a dose of 400 mg/kg of amino acid or 2 ml of phosphate-buffered saline (PBS) (as control) intraperitoneally. All rats were sacrificed at 4 hrs after the injection of 1 MBq 111In-DOTATOC. Samples of the kidney were taken and weighed carefully. The counts of radioactivity were measured by a gamma counter and renal concentrations were calculated and expressed as percent injected dose per gram (% ID/g). RESULTS:The renal uptake of 111In-DOTATOC was significantly lower for all three kinds of amino acids when compared to the control group. The renal uptake of 111In-DOTATOC in the lysine group was significantly lower than those in the histidine and arginine groups. The renal uptake of 111In-DOTATOC in the histidine group was lower than that in the arginine group, but no statistical difference was noted. CONCLUSION:Among these three amino acids, lysine had the best reduction rate of renal uptake of DOTATOC. Histidine was more effective than arginine but no statistical difference was noted.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Lin YC,Hung GU,Luo TY,Tsai SC,Sun SS,Hsia CC,Chen SL,Lin WYdoi
10.1007/BF03034003subject
Has Abstractpub_date
2007-01-01 00:00:00pages
79-83issue
1eissn
0914-7187issn
1864-6433journal_volume
21pub_type
杂志文章abstract：:Morphine intervention in cholescintigraphy decreases imaging time to diagnose acute cholecystitis. Not infrequently we observe duodenogastric reflux during scintigraphy with and without morphine intervention. To evaluate occurrence of duodenogastric reflux related to morphine, we reviewed 55 patients who underwent cho...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03168405
更新日期：1995-11-01 00:00:00
abstract：PURPOSE:Tumor recurrence of colorectal cancers (CRC) is generally followed up by analyses of the serum carcinoembryonic antigen (CEA) levels. However, recent evidence suggests that tumor recurrence can also be visualized by 18F-fluoro-deoxyglucose emission tomography/computed tomography (FDG-PET/CT) in patients with no...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-012-0609-0
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to investigate whether total lesion glycolysis (TLG) and metabolic tumor volume (MTV) measured by ¹⁸F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) could predict the aggressiveness and lymph node metastasis (LNM) in patients with incid...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-015-0994-2
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:4-Benzyl-1-(3-iodobenzylsulfonyl)piperidine, 4-B-IBSP, has shown high-binding affinity to both sigma (σ) receptors in our previous work. In current study, radiolabeling and preclinical evaluation of 4-benzyl-1-(3-[125I]-iodobenzylsulfonyl)piperidine, 4-B-[125I]IBSP, in human ductal breast carcinoma (T47D) cel...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-017-1161-8
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to determine whether (11)C-hydroxyephedrine ((11)C-HED) can predict adverse events including all-cause death in Japanese patients with left ventricular (LV) dysfunction. BACKGROUND:Although (11)C-HED PET has been used to assess cardiac sympathetic innervation in various disease con...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-016-1081-z
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:The Response Evaluation Criteria In Solid Tumors (RECIST) is the most used radiological method for evaluating response after peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine tumors. This method may give too positive estimates of response in slow growing tumors as it allows a substa...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-018-1316-2
更新日期：2019-03-01 00:00:00
abstract：UNLABELLED:The purpose of this study was to validate a double-injection (DI) method with N-isopropyl-[123I]p-iodoamphetamine (IMP) to measure regional cerebral blood flow (rCBF) twice in a single session of dynamic SPECT and to elucidate a possible role of this method to identify patients with occlusive disease of majo...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF02987833
更新日期：2001-06-01 00:00:00
abstract：OBJECTIVE:Although extensive work has been done on cigarette smoking and its effects on pulmonary function, there are limited number of studies on water-pipe smoking. The effects of water-pipe smoking on health are not widely investigated. The aim of this study was to determine the effects of water-pipe smoking on pulm...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF02984465
更新日期：2004-06-01 00:00:00
abstract：:Most of the acute ischemic events, such as acute coronary syndromes and stroke, are attributed to vulnerable plaques. These lesions have common histological and pathophysiological features, including inflammatory cell infiltration, neo-angiogenesis, remodelling, haemorrhage predisposition, thin fibrous cap, large lipi...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章,评审
doi：10.1007/s12149-020-01458-7
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVES:Visceral leishmaniasis (VL) is the most severe manifestation of the infection caused by the protozoan Leishmania, recently on increase in Italy and Spain. The aim of the study was to describe FDG uptake patterns in VL patients (pts) who underwent 18F-FDG PET/CT. METHODS:A retrospective monocentric study of ...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-019-01381-6
更新日期：2019-09-01 00:00:00
abstract：:In practical positron emission tomography (PET) diagnosis, a shortened protocol is preferred for patients with brain disorders. In this study, the applicability of a shortened protocol as an alternative to the 90-min PET scan with [(11)C]SA4503 for quantitative sigma(1) receptor measurement was investigated. Tissue ti...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-007-0088-x
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:To examine the patterns of longitudinal tau accumulation and cortical atrophy and their association in subjects with mild cognitive impairment (MCI). METHODS:We collected 23 participants (60-89 years old, 11 males/12 females) with MCI from the Alzheimer's Disease Neuroimaging Initiative database. All partici...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-020-01506-2
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to measure the apparent diffusion coefficient (ADC) value at the region with the highest FDG uptake using sequential (18)F-FDG PET and MRI, and to correlate it with the histological grade of invasive ductal carcinoma (IDC) of the breast. METHODS:A retrospective study was conducted o...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-013-0737-1
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:The presence of central lymph node (LN) metastasis increases the risk of cervical LN recurrence or distant metastasis in patients with papillary thyroid microcarcinoma (PTMC). We investigated the value of preoperative (18)F-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG PET)-computerized tomography ...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-012-0594-3
更新日期：2012-07-01 00:00:00
abstract：:Technetium-99m tetrofosmin and thallium-201 lung SPECT imaging were performed in a patient with adenocarcinoma of the lung. Significant activities in the lung lesion were clearly depicted on both technetium-99m tetrofosmin and thallium-201 SPECT imaging. The early uptake, delayed uptake ratios and retention indices of...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03165069
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVE:Lung clearance rates of inhaled (99m)Tc-DTPA aerosols constitute a sensitive index to evaluate the permeability changes characteristic of airway epithelial damage. It was thought that edema of the airway wall which is reported in asthma could be relieved with a diuretic like furosemide, helping to relieve the...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s12149-009-0275-z
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:Rest thallium-201 (201Tl) myocardial perfusion imaging has been widely used for evaluation of myocardial ischemia/viability after myocardial infarction, but the ideal timing for imaging after injection to maximally estimate viability is not well established. METHODS:Thirty-six patients with myocardial infar...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF02985586
更新日期：2006-01-01 00:00:00
abstract：AIM:The purpose of the study was to determine the lung toxicity caused by amiodarone (AD) and bleomycin (BLM) in rats, by means of Tc-99m HMPAO lung scintigraphy. METHODS:Thirty albino rats were randomly divided into five groups. After AD or BLM was dissolved with isotonic saline (SF), a 0.5 ml solution was applied to...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-013-0722-8
更新日期：2013-08-01 00:00:00
abstract：:Nerve growth factor (NGF) exerts various actions on neuronal and non-neuronal tissues and has potential therapeutic utility, but difficulties in using the whole protein have stimulated interest in small NGF fragments. We radioiodinated a small cyclic peptide derived from NGF using the Bolton-Hunter method [125I-C(92-9...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03026817
更新日期：2006-10-01 00:00:00
abstract：:We are proposing a new method for correcting of scattered photons in technetium-99m (99mTc) imaging by means of photopeak dual-energy window acquisition. This method consists of the simultaneous acquisition of two images and estimation of a scatter image included in the symmetric energy window (SW) image by the differ...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03178307
更新日期：1992-08-01 00:00:00
abstract：OBJECTIVE:Estimation of myocardial blood flow (MBF) and coronary flow reserve (CFR) by SPECT myocardial perfusion imaging (MPI) remains challenging. Our aim was to approximate MBF and CFR by quantifying the absolute Tc-99m tetrofosmin retention in the myocardium via gated-SPECT/CT MPI. METHODS:Tracer retention was cal...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s12149-015-0982-6
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:The objectives of this study were to (1) elucidate the relationship between the mean CBF in the whole brain (Av.mCBF) before rehabilitation of CVD patients and the BI score before and after rehabilitation, (2) determine whether the efficacy of rehabilitation can be predicted by measurement of the Av.mCBF, and (...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF02990478
更新日期：2000-02-01 00:00:00
abstract：OBJECTIVE:In high-risk patients with left bundle-branch block (LBBB), functional but not perfusion parameters yield incremental prognostic information. The aim of our study was to evaluate the prognostic value of gated single photon emission computed tomography (SPECT) in low-intermediate risk LBBB patients. METHODS:O...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-012-0613-4
更新日期：2012-08-01 00:00:00
abstract：RATIONALE:Myocardial perfusion SPECT is a commonly performed, well established, clinically useful procedure for the management of patients with coronary artery disease. However, the attenuation of photons from myocardium impacts the quantification of infarct sizes. CT-Attenuation Correction (AC) potentially resolves th...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-017-1211-2
更新日期：2017-12-01 00:00:00
abstract：:Scintigraphy with 99mTc-diethylenetriamine pentaacetic acid galactosyl human serum albumin (99mTc-GSA) was performed on 102 patients, then the hepatic extraction fraction (HEF), the rate constant for liver uptake of the tracer from the blood (K1) and the hepatic blood flow index (HBFI) were determined by spectral anal...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF02988293
更新日期：2000-12-01 00:00:00
abstract：:To evaluate two methods for decreasing and/or diluting the FDG activity in the urinary system, five rats were intraperitoneally given 1,000 micrograms/g of L-lysine 4 times, starting from 60 minutes before iv injection of FDG, and then at 30-minute intervals for 90 minutes. Five rats were used as controls. In a furose...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03164766
更新日期：1997-08-01 00:00:00
abstract：:(-)-O-Methylvesamicol ((-)-OMV) exhibited in vitro a high affinity for vesicular acetylcholine transporter (VAChT) (Ki, 6.7 nM) and a relatively low affinity for sigmal receptor (Ki, 33.7 nM). We prepared (-)-[11C]OMV by a palladium-promoted cross-coupling reaction using [11C]methyl iodide, in a radiochemical yield of...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03027377
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVE:To determine an appropriate threshold value for delineation of the target in positron emission tomography (PET) and to investigate whether PET can delineate an internal target volume (ITV), a series of phantom studies were performed. METHODS:An ellipse phantom (background) was filled with 1028 Bq/ml of [(18)...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-008-0166-8
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:Studies have suggested that ischemia-induced diastolic dysfunction persists longer than systolic dysfunction. We examined whether global left ventricular (LV) diastolic function during stress testing assessed by 16-frame gated myocardial perfusion single-photon emission computed tomography (SPECT) is useful a...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-008-0174-8
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to investigate the effects of computed tomography (CT) artifacts caused by dental metal prostheses on positron emission tomography (PET) images. METHODS:A dental arch cast was fixed in a cylindrical water-bath phantom. A spherical phantom positioned in the vicinity of the dent...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-009-0254-4
更新日期：2009-07-01 00:00:00
