Activation of beta-catenin in the stem cell region of crypts during growth of the small intestine in infant rats.

abstract：:The purpose of this study was to determine the effects of altering gastric emptying on postprandial plasma glucose concentration after a physiologic meal in patients with type II diabetes mellitus (T II DM). Nine T II DM patients underwent a double-blind, randomized, three-way crossover study, receiving erythromycin 2...

journal_title：Digestive diseases and sciences

authors： Gonlachanvit S,Hsu CW,Boden GH,Knight LC,Maurer AH,Fisher RS,Parkman HP

更新日期：2003-03-01 00:00:00

abstract：:Phosphorylation/dephosphorylation of intracellular proteins are important steps in the regulation of cell growth. Okadaic acid, an inhibitor of the serine/threonine protein phosphatases 1 and 2A, is a potent tumor promoter. This effect may be through the inhibition of dephosphorylation (termed "hyperphosphorylation") ...

journal_title：Digestive diseases and sciences

authors： Hirai A,Bold RJ,Ishizuka J,Hirai M,Townsend CM Jr,Thompson JC

更新日期：1996-10-01 00:00:00

abstract：:Leptin is a 16-kDa nonglycosylated protein primarily secreted from the adipocytes of white fat; minor levels of regulated leptin expression also occurs at other sites such as placenta, skeletal muscle, the stomach fundus, and culture-activated hepatic stellate cells (HSCs). Leptin is primarily involved in the regulati...

journal_title：Digestive diseases and sciences

authors： Bethanis SK,Theocharis SE

更新日期：2006-10-01 00:00:00

abstract：:The aim of this study was to examine the effect of the antithrombotic drugs aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of liver cirrhosis and to determine if these two drugs are beneficial in animals with advanced fibrosis or with established cirrhosis undergoing partial he...

journal_title：Digestive diseases and sciences

authors： Assy N,Hussein O,Khalil A,Luder A,Szvalb S,Paizi M,Spira G

更新日期：2007-05-01 00:00:00

abstract：:In order to assess the effects of free or resin-bound bile acids on colonic topography, adult rats were surgically provided with an indwelling infusion catheter in the proximal cecum, which exited at the neck behind the head. Conscious, unrestrained rats were allowed chow ad libitum and were administered 1 ml of an in...

journal_title：Digestive diseases and sciences

authors： Vahouny GV,Satchithanandam S,Lightfoot F,Grau L,Haas-Smith S,Kritchevsky D,Cassidy MM

更新日期：1984-05-01 00:00:00

abstract：:The pathophysiology of constipation after rectopexy remains unclear: acquired anorectal dysfunction or preoperative colonic state are, by turns, the supposed culprit. The aim of this prospective study was to characterize the colorectal motility abnormalities encountered after such a surgical procedure. Twelve patients...

journal_title：Digestive diseases and sciences

authors： Siproudhis L,Ropert A,Gosselin A,Bretagne JF,Heresbach D,Raoul JL,Gosselin M

更新日期：1993-10-01 00:00:00

abstract：:Somatostatin analog SMS 201-995 causes a dose-related suppression of the release and/or action of several gastrointestinal hormones and impairs several anterior pituitary functions. Some patients with illness involving abnormal hormonal activity have responded to treatment with SMS 201-995, including resolution of sev...

journal_title：Digestive diseases and sciences

authors： Greenberg RN

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Fecal Occult Blood Test (FOBT) is an accepted screening test for colorectal cancer (CRC). It has been shown to decrease mortality by up to 30%. The outcome of screening failures has not been adequately studied. AIMS:The purpose of this study was to assess the outcome of patients who were diagnosed with CRC ...

journal_title：Digestive diseases and sciences

authors： Half EE,Mlynarsky L,Naftali T,Benjaminov F,Konikoff FM

更新日期：2013-09-01 00:00:00

abstract：:We have developed an improved semiconductor recording probe for monitoring motility of the upper small intestine in humans. The probe consists of six ultraminiature silicon pressure sensors spaced 10 cm apart and encased in a flexible polyurethane sheath. The probe is small [2.67 mm (8F) diameter], is easily passed tr...

journal_title：Digestive diseases and sciences

authors： Mathias JR,Sninsky CA,Millar HD,Clench MH,Davis RH

更新日期：1985-02-01 00:00:00

abstract：:In this study, two antiallergic compounds, betamethasone and disodium cromoglycate were tested in an animal model of intestinal anaphylaxis. Rats, immunized with Nippostrongylus brasiliensis, were challenged intravenously with whole worm antigen or saline. Antigen challenge resulted in significant abnormalities: epith...

journal_title：Digestive diseases and sciences

authors： D'Incà R,Hunt RH,Perdue MH

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:SEL1L gene product is implicated in the endoplasmic reticulum (ER)-associated protein degradation and Unfolded Protein Response pathways. This gene and associated miRNAs have been indicated as predictive and prognostic markers of pancreatic cancer. AIM:Explore the role of SEL1L in colorectal cancer (CRC) pr...

journal_title：Digestive diseases and sciences

authors： Ashktorab H,Green W,Finzi G,Sessa F,Nouraie M,Lee EL,Morgano A,Moschetta A,Cattaneo M,Mariani-Costantini R,Brim H,Biunno I

更新日期：2012-04-01 00:00:00

abstract：:Cyclin D1 plays an important role in the multi-step process of gastrointestinal tumorigenesis. We hypothesize that normal enterocytes over-expressing cyclin D1 will demonstrate a transformed phenotype. The nontumorigenic intestinal epithelial cell line, IEC-18, was transfected with the vector pMV7-CCND1, encoding cycl...

journal_title：Digestive diseases and sciences

authors： Kazanov D,Shapira I,Pick M,Kolker O,Liberman E,Deutsch V,Strier L,Dvory-Sobol H,Kunik T,Arber N

更新日期：2003-07-01 00:00:00

abstract：:Intraoperative radiation therapy has been introduced to improve survival rates after resection of biliopancreatic cancer. Early and late effects of intraoperative radiation on the exocrine and endocrine functions of the residual pancreas were examined in 54 patients with pancreatic head resection. Of the 54 patients, ...

journal_title：Digestive diseases and sciences

authors： Yamaguchi K,Nakamura K,Kimura M,Yokohata K,Noshiro H,Chijiiwa K,Tanaka M

更新日期：2000-06-01 00:00:00

abstract：:The aim of this study was to compare alcohol and smoking as risk factors in the development of chronic pancreatitis and pancreatic cancer. We considered only male subjects: (1) 630 patients with chronic pancreatitis who developed 12 pancreatic and 47 extrapancreatic cancers; (2) 69 patients with histologically well do...

journal_title：Digestive diseases and sciences

authors： Talamini G,Bassi C,Falconi M,Sartori N,Salvia R,Rigo L,Castagnini A,Di Francesco V,Frulloni L,Bovo P,Vaona B,Angelini G,Vantini I,Cavallini G,Pederzoli P

更新日期：1999-07-01 00:00:00

abstract：:Three cases of gastritis glandularis et cystica profunda are presented, two associated with severe chronic gastritis and the other with invasive gastric carcinoma and chronic gastritis. This poorly known entity consists of benign downgrowths of deep gastric glands through the muscularis mucosae into the submucosa. The...

journal_title：Digestive diseases and sciences

authors： Honoré LH,Lewis AS,O'Hara KE

更新日期：1979-01-01 00:00:00

abstract：:Aging and gastrointestinal malignancies, including that of the stomach are associated with increased activation of EGF-receptor (EGFR). Although the intracellular events that regulate this process are poorly understood, we hypothesize that loss of ERRP (EGFR-related protein; GenBank accession number AF187818), a recen...

journal_title：Digestive diseases and sciences

authors： Majumdar AP,Du J,Hatfield JS,Levi E,Adsay V,Schmelz EM,Nagothu KK,Jaszewski R,Kucuk O,Sarkar FH

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Regular screening of cirrhotic patients for hepatocellular carcinoma (HCC) has been suboptimal, but there is little data regarding specific risk factors for reduced screening. METHODS:From 1996 to 2010, patients with cirrhosis were retrospectively identified from outpatient gastroenterology and primary care...

journal_title：Digestive diseases and sciences

authors： Patwardhan V,Paul S,Corey KE,Mazhar SM,Richter JM,Thiim M,Chung RT

更新日期：2011-11-01 00:00:00

abstract：:Excessive spontaneous swallowing has been associated with a variety of common gastrointestinal symptoms including abdominal pain, heartburn, and bloating and may contribute to disorders such as hiatus hernia, duodenal ulcer, and irritable bowel syndrome. The present study investigated the hypothesis that changes in em...

journal_title：Digestive diseases and sciences

authors： Cuevas JL,Cook EW 3rd,Richter JE,McCutcheon M,Taub E

更新日期：1995-02-01 00:00:00

abstract：:Orlistat (tetrahydrolipstatin) is a potent inhibitor of gastric and pancreatic lipase activity causing a diminution of free fatty acids in the intestinal lumen. The release of cholecystokinin (CCK) critically depends on the presence of free fatty acids in the small intestine. Postprandial CCK release and gallbladder c...

journal_title：Digestive diseases and sciences

authors： Froehlich F,Hartmann D,Guezelhan C,Gonvers JJ,Jansen JB,Fried M

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:One of the problems associated with infliximab (IFX) treatment for Crohn's disease (CD) is loss of response during maintenance therapy. AIMS:The aim of this multicenter, retrospective, cohort study was to determine whether enteral nutrition (EN) added to the IFX therapy regimen is effective for maintaining ...

journal_title：Digestive diseases and sciences

authors： Hirai F,Ishihara H,Yada S,Esaki M,Ohwan T,Nozaki R,Ashizuka S,Inatsu H,Ohi H,Aoyagi K,Mizuta Y,Matsumoto T,Matsui T

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) screening is a priority for the Veteran's Health Administration (VHA). Optimizing fecal occult blood testing (FOBT) is integral to CRC screening in health care systems. AIMS:The purpose of this study was to characterize the utilization of CRC testing in a large integrated health care...

journal_title：Digestive diseases and sciences

authors： Long MD,Lance T,Robertson D,Kahwati L,Kinsinger L,Fisher DA

更新日期：2012-02-01 00:00:00

abstract：:Local or national policy, patients' preferences, safety and/or economic concerns, or reimbursement issues may dictate stopping drug in inflammatory bowel diseases (IBD) patients. Sustained deep remission is an important predictor of a better outcome after anti-tumor necrosis (TNF) factor therapy discontinuation, inclu...

journal_title：Digestive diseases and sciences

authors： Williet N,Paul S,Peyrin-Biroulet L,Roblin X

更新日期：2016-04-01 00:00:00

abstract：:In a retrospective study, 50 patients with obvious necrotizing pancreatitis (NP) were allocated in four groups according to the morphological aspects of the necrosis. Appearance of ascite (N1), extrapancreatic spread of necrosis towards neighboring organs (N2), a large amount of necrosis (N3), and infected necrosis (N...

journal_title：Digestive diseases and sciences

authors： Le Mée J,Janny S,Sauvanet A,Werner P,Belghiti J

更新日期：1997-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) as an indication to liver transplant (LT) started as palliative treatment, then moved to potentially curative anti-cancer therapy and more recently entered the era of competition with non-cancer indications, consequent to the need of the society to target equal distribution of the limite...

journal_title：Digestive diseases and sciences

authors： Sposito C,Cucchetti A,Mazzaferro V

更新日期：2019-04-01 00:00:00

abstract：:Bombesin or gastrin-releasing peptide prevents gastric injury by an unknown mechanism. Since exogenous gastrin is a gastroprotective agent, this study was undertaken to test the hypothesis that gastroprotection by bombesin involves release of endogenous gastrin. Subcutaneous bombesin (10-100 microg/kg) dose dependentl...

journal_title：Digestive diseases and sciences

authors： Mercer DW,Cross JM,Chang L,Lichtenberger LM

更新日期：1998-04-01 00:00:00

abstract：:We report a case of localized jejunal amyloidosis occurring in a 74-year-old man who experienced an episode of digestive bleeding while he was receiving oral anticoagulation. It illustrates a rare entity, characterized by an endoscopic aspect of polypoid, pseudotumoral formations. Histologically, submucosal connective...

journal_title：Digestive diseases and sciences

authors： Peny MO,Debongnie JC,Haot J,Van Gossum A

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Eosinophilic esophagitis is among the causes of refractory reflux disease. Biopsy of esophagus is the gold standard for diagnosis. In this study we determined the frequency of eosinophilic esophagitis (EE) in refractory reflux cases referred to Motility Department of Shahid Beheshti Research Center of Gastro...

journal_title：Digestive diseases and sciences

authors： Foroutan M,Norouzi A,Molaei M,Mirbagheri SA,Irvani S,Sadeghi A,Derakhshan F,Tavassoli S,Besharat S,Zali M

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:With an increasing number of available therapies for inflammatory bowel disease (IBD), little is known about patients' attitudes regarding IBD-related direct-to-consumer advertising (IBD-DTCA) and its impact on treatment decisions in clinical practice. METHODS:We administered a 58-item, mailed questionnai...

journal_title：Digestive diseases and sciences

authors： Gu P,Yang E,Chittajallu P,McNeill C,Singal AG,Kwon JH,Ahmed TF

更新日期：2021-01-01 00:00:00

abstract：:The present paper evaluates the efficiency of Nissen fundoplication as an antireflux technique in a series of 51 patients with different grades of esophagitis. Follow-up time averaged 6.6 years. The evaluation includes a clinical assessment, endoscopic study, and 24-hr pH monitoring. The results reveal an acceptable r...

journal_title：Digestive diseases and sciences

authors： Martinez de Haro LF,Ortiz A,Parrilla P,Garcia Marcilla JA,Aguayo JL,Morales G

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Amoxicillin, metronidazole, proton pump inhibitor, bismuth quadruple therapy had been shown to reliably achieve high eradication rates. The role of individual components remains undefined. AIM:To identify the additional benefit/role of bismuth in amoxicillin, metronidazole, proton pump inhibitor, bismuth qu...

journal_title：Digestive diseases and sciences

authors： Luo L,Ji Y,Yu L,Huang Y,Liang X,Graham DY,Lu H

更新日期：2020-12-01 00:00:00