Abstract:
:The parameters of the immune response dynamics are usually estimated by the use of deterministic ordinary differential equations that relate data trends to parameter values. Since the physical basis of the response is stochastic, we are investigating the intensity of the data fluctuations resulting from the intrinsic response stochasticity, the so-called process noise. Dealing with the CD8+ T-cell responses of virus-infected mice, we find that the process noise influence cannot be neglected and we propose a parameter estimation approach that includes the process noise stochastic fluctuations. We show that the variations in data can be explained completely by the process noise. This explanation is an alternative to the one resulting from standard modeling approaches which say that the difference among individual immune responses is the consequence of the difference in parameter values.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Milutinovic D,De Boer RJdoi
10.1529/biophysj.106.094508subject
Has Abstractpub_date
2007-05-15 00:00:00pages
3358-67issue
10eissn
0006-3495issn
1542-0086pii
S0006-3495(07)71142-6journal_volume
92pub_type
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