Abstract:
BACKGROUND AND OBJECTIVE:Glucagon-like-peptide-1 (7-36) amide (GLP-1) is an insulin secretagogue and potential treatment for type II diabetes mellitus. An alternative to GLP-1 administration is endogenous dietary stimulation. We described a greater GLP-1 release following ingestion of liquids versus solids. We add to this work studying the effect of fluid preloads with differing glycaemic indices (GI) on the metabolic response to a meal. SUBJECTS AND DESIGN:GLP-1, insulin and glucose responses were measured in six overweight individuals and six subjects with type II diabetes on three occasions, after preload (milk, low GI; Ovaltine Light, high GI; or water, non-nutritive control) and meal ingestion. RESULTS:In people with and without diabetes, the high GI preload produced the greatest glucose incremental area under the curve (IAUC)(0-20), followed by the low GI preload, and water (P<0.001). In both groups, insulin IAUC(0-20) was higher following high and low GI preloads compared with water (NS). In people without diabetes, the GLP-1 response was higher when high and low GI preloads were consumed compared with water (P=0.041), with no significant difference between nutritive preloads. GLP-1 response did not differ between preloads in people with diabetes. Despite initial differences, total IAUCs(0-200) for biochemical variables did not differ by preload. CONCLUSION:We confirm that nutritive liquids stimulate GLP-1 to a greater extent than water in subjects without diabetes; however, this does not influence subsequent meal-induced response. The GI of preloads does not influence the degree of GLP-1 stimulation.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Milton JE,Sananthanan CS,Patterson M,Ghatei MA,Bloom SR,Frost GSdoi
10.1038/sj.ejcn.1602654subject
Has Abstractpub_date
2007-12-01 00:00:00pages
1364-72issue
12eissn
0954-3007issn
1476-5640pii
1602654journal_volume
61pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:To assess the phytate intake and molar ratios of phytate to calcium, iron and zinc in the diets of people in China. DESIGN:2002 China Nationwide Nutrition and Health Survey is a cross-sectional nationwide representative survey on nutrition and health. The information on dietary intakes was collected using co...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602513
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:Several studies have found an inverse association between fish consumption and risk of dementia. The objective of this study was to describe the characteristics of older fish consumers, in order to identify potential confounders in this relationship. DESIGN:Cross-sectional analysis of the baseline data of a ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.ejcn.1602145
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Snacking has increased globally. We examine snacking patterns and common snack foods in Brazil. SUBJECTS/METHODS:Data from the first of two non-consecutive food diaries from 34,003 individuals (aged ≥ 10 years) in the first Brazillian nationally representative dietary survey (2008-2009) were used...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2013.60
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Vitamin B(12) (B(12)) deficiency is common in Indians and a major contributor to hyperhomocysteinemia, which may influence fetal growth, risk of type II diabetes and cardiovascular disease. The purpose of this paper was to study the effect of physiological doses of B(12) and folic acid on plasma t...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/ejcn.2010.15
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The roles of vitamin B12 and homocysteine concentration in depression are not clear. We investigated cross-sectional and prospective associations of serum vitamin B12 and plasma homocysteine with depressive symptoms in Dutch older adults. SUBJECTS/METHODS:In the Longitudinal Aging Study Amsterdam...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2016.224
更新日期:2017-04-01 00:00:00
abstract::The relevance of nutritional indices derived from comparison with growth standards to assess the risk of dying was evaluated in a 2-year prospective study in rural Senegal. An average of 3151 children aged 6-59 months were measured twice a year and followed up during the intervening 6-month periods. Children who survi...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract:OBJECTIVE:Elevated hearing thresholds have been demonstrated in populations afflicted by endemic cretinism as a result of severe iodine deficiency. However, data on the effects of less severe iodine deficiency on hearing thresholds in apparently normal children are scant. This study addresses the question whether there...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1601220
更新日期:2001-09-01 00:00:00
abstract::The validity of [15N]glycine and [13C]leucine as tracers for investigating albumin fractional synthetic rate (FSR) has been explored by simultaneous infusion of both amino acids into 5 normal female subjects. Albumin FSR, calculated from the urinary [15N]urea plateau value and the incorporation of arginine into albumi...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:In view of the ongoing debate on "chronic malnutrition" and the concept of "stunting" as "a better measure than underweight of the cumulative effects of undernutrition and infection (WHO)", we translate, briefly comment and re-publish three seminal historic papers on catch-up growth following re-feeding afte...
journal_title:European journal of clinical nutrition
pub_type: 历史文章,杂志文章,评审
doi:10.1038/s41430-018-0274-z
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:There is little objective information regarding nutrition transition in African countries. We assessed trends in nutrition patterns in the Seychelles between 1989 and 2011. SUBJECTS/METHODS:Population-based samples were obtained in 1989, 1994 and 2011 and participants aged 25-44 are considered in...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2012.199
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:The effect of a diet rich in monounsaturated fatty acids (MUFA) on blood pressure, glycemic control, lipids and insulin sensitivity was evaluated in women with gestational diabetes mellitus. DESIGN AND METHODS:A randomized, unpaired diet intervention was performed in 27 women with gestational diabetes mellit...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1601193
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Few studies in Latin American paediatric populations have differentiated fat deposits in specific areas, such as intra-abdominal fat (IAF) and subcutaneous abdominal fat (SAF). Research in diverse populations is needed, as patterns of fat accumulation vary by ethnicity. The aim of this study was to...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2017.28
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To collect (i) baseline data and (ii) execute a large multicentre study examining the effect of trans alpha-linolenic acid on its incorporation into plasma lipids and on risk factors for coronary heart disease. DESIGN:Male volunteers were recruited and the habitual diet assessed by a 4-d weighed record. Fatt...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1600903
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of dosage on the metabolic response to vegetables added to a mixed lunch meal, and to relate the amounts to the tripartite plate model. Carrots were chosen as an example, and the carrots were blanched, frozen and boiled to include possible effects of processing and cooking. The effects ...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-06-01 00:00:00
abstract::Both high and low vitamin D statuses have been associated with lower memory function. Apolipoprotein E (APOE) ɛ4 alleles have been associated with reduced memory function, and separately with higher vitamin D concentrations. This report aims to examine if the presence of APOE ɛ4 alleles contributes to the relationship...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2014.201
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Exclusive breastfeeding is recommended till 6 months age. Factors regulating the breastmilk iron and lactoferrin levels are incompletely known. Considering high prevalence of nutritional anemia in lactating mothers, we studied the iron status of lactating mothers, their breastmilk iron and lactoferrin levels ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602398
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Food labels may have an important function in communicating nutrition information and have considerable potential to influence food choice and dietary behaviour. OBJECTIVES:To assess the validity and reliability of a short (self-complete) questionnaire designed to measure consumers' use and understanding of...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2009.126
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Several studies have addressed the validity of ultrasound (US) for body composition assessment, but few have evaluated its reliability. This study aimed to determine the reliability of percent body fat (%BF) estimates using A-mode US in a heterogeneous sample. SUBJECTS/METHODS:A group of 144 heal...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-00743-y
更新日期:2020-09-11 00:00:00
abstract:OBJECTIVE:To compare the most commonly used equations to predict body fatness from skinfold thickness, in male and female adolescents, with dual-energy X-ray absorptiometry (DXA) as a reference method of fatness measurement. DESIGN:Cross-sectional nutrition survey. SETTING:General adolescent population from Zaragoza ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602226
更新日期:2005-10-01 00:00:00
abstract::The nutritional impact of a water and sanitation intervention in a rural community of Bangladesh, comprising the provision of handpumps, construction of latrines and hygiene education was assessed. During 3 years, the quarterly anthropometric measures of about 200 children aged 12-35 months from the intervention commu...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract::The association of components of a low saturated fat (SFA) and of a Mediterranean diet was tested with atherosclerosis biomarkers in 190 familial hypercholesterolemia adults (FH) from Brazil (BR) and Spain (SP). Median blood LDL-C, Apolipoprotein B (apoB), and C reactive protein (hs-CRP) concentrations were higher in ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-019-0529-3
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:We have investigated the influence of vitamin C diet supplementation on the antioxidant response and nitrite levels in lymphocytes and erythrocytes during diving apnea. SUBJECTS:Seven male professional apnea divers participated in a double blind crossover study. Divers were randomly assigned to either vitami...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602388
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To explore the associations between serum concentrations of vitamin D (25(OH)D) and all-cause mortality among US adults defined by lung function (LF) status, particularly among adults with obstructive LF (OLF). METHODS:Data from 10,795 adults aged 20-79 years (685 with restrictive LF (RLF) and 1309 with OLF)...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2014.162
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To determine whether diet supplementation with arabinoxylan-rich (AX)-fibre from wheat improves glycaemic control in Type II diabetes. DESIGN:Randomized, crossover intervention trial. SETTING:Monash Medical Centre. SUBJECTS:A total of 15 subjects with Type II diabetes. INTERVENTIONS:Over two 5-week period...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1601857
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Infant and young child feeding (IYCF) has not been documented in central and western China, where anaemia is prevalent. To support policy advocacy, we assessed IYCF and anaemia there using standardized methods. SUBJECTS/METHODS:A community-based, cross-sectional survey of 2244 children aged 6-23 ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2014.98
更新日期:2014-08-01 00:00:00
abstract::An oat bran concentrate was prepared by removing non-fibre components by cold-water wet-milling, resulting in a 2- to 3-fold concentration of soluble fibre, with beta-D-glucan as its main component. The concentrate was baked in bread which was consumed for 8 weeks by free-living men with mild to moderate hypercholeste...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Vitamin D status has been associated with fetal growth and offspring's bone mass in some observational studies. We characterize the trajectory of total maternal serum 25-hydroxyvitamin D [25(OH)D] concentration by race and examine whether vitamin D status is associated with neonatal anthropometry ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0212-0
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:The object of this study was to investigate the in vivo antioxidant effect of green tea and dosage effect of green tea on antioxidant effect. DESIGN:We tested 10 healthy subjects (aged 23-25 y, five women and five men) with overnight fasting. The total antioxidant capacity of plasma was measured at baseline ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600994
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:To validate bio-electric impedance spectroscopy (BIS) by comparison with other methods for determination of body water compartments in stable subjects with an ileostomy and no or minor small bowel resection for inflammatory bowel disease (IBD). SUBJECTS:Twenty-one subjects were included, age range 36-65 y (f...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601378
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:To study the variation in selenoprotein P levels in serum among healthy subjects from 17 European regions representing nine countries. SUBJECTS:Survey of 414 37-70-year-old subjects (197/217 males/females) from 17 regions. RESULTS:The level of selenoprotein P varied significantly among regions and countries...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00