Abstract:
:It is known that the action of general anesthetics is proportional to their partition coefficient in lipid membranes (Meyer-Overton rule). This solubility is, however, directly related to the depression of the temperature of the melting transition found close to body temperature in biomembranes. We propose a thermodynamic extension of the Meyer-Overton rule, which is based on free energy changes in the system and thus automatically incorporates the effects of melting point depression. This model accounts for the pressure reversal of anesthesia in a quantitative manner. Further, it explains why inflammation and the addition of divalent cations reduce the effectiveness of anesthesia.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Heimburg T,Jackson ADdoi
10.1529/biophysj.106.099754subject
Has Abstractpub_date
2007-05-01 00:00:00pages
3159-65issue
9eissn
0006-3495issn
1542-0086pii
S0006-3495(07)71124-4journal_volume
92pub_type
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