Design and analysis of small-scale transmission experiments with animals.

Abstract:

:Interactions between pathogens and hosts at the population level should be considered when studying the effectiveness of control measures for infectious diseases. The advantage of doing transmission experiments compared to field studies is that they offer a controlled environment in which the effect of a single factor can be investigated, while variation due to other factors is minimized. This paper gives an overview of the biological and mathematical aspects, bottlenecks and solutions of developing and executing transmission experiments with animals. Different methods of analysis and different experimental designs are discussed. Final size methods are often used for analysing transmission data, but have never been published in a refereed journal; therefore, they will be described in detail in this paper. We hope that this information is helpful for scientists who are considering performing transmission experiments.

journal_name

Epidemiol Infect

authors

Velthuis AG,Bouma A,Katsma WE,Nodelijk G,De Jong MC

doi

10.1017/S095026880600673X

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

202-17

issue

2

eissn

0950-2688

issn

1469-4409

pii

S095026880600673X

journal_volume

135

pub_type

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