Abstract:
:Interactions between pathogens and hosts at the population level should be considered when studying the effectiveness of control measures for infectious diseases. The advantage of doing transmission experiments compared to field studies is that they offer a controlled environment in which the effect of a single factor can be investigated, while variation due to other factors is minimized. This paper gives an overview of the biological and mathematical aspects, bottlenecks and solutions of developing and executing transmission experiments with animals. Different methods of analysis and different experimental designs are discussed. Final size methods are often used for analysing transmission data, but have never been published in a refereed journal; therefore, they will be described in detail in this paper. We hope that this information is helpful for scientists who are considering performing transmission experiments.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Velthuis AG,Bouma A,Katsma WE,Nodelijk G,De Jong MCdoi
10.1017/S095026880600673Xsubject
Has Abstractpub_date
2007-02-01 00:00:00pages
202-17issue
2eissn
0950-2688issn
1469-4409pii
S095026880600673Xjournal_volume
135pub_type
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