Abstract:
:Prophylactic treatment with human granulocyte colony-stimulating factor (hG-CSF) affords significant protection against systemic aspergillosis or pulmonary aspergillosis in neutropenic (cyclophosphamide-treated) mice but not in cortisone-treated animals. Cryptococcosis does not respond to hG-CSF therapy. Our data show that granulocytes play an important role in the immune defense against aspergillosis, but not against cryptococcosis. Combined treatment using hG-CSF and conventional antimycotics shows a significant beneficial effect in systemic or pulmonary aspergillosis.
journal_name
Mycosesjournal_title
Mycosesauthors
Polak-Wyss Adoi
10.1111/j.1439-0507.1991.tb00645.xsubject
Has Abstractpub_date
1991-05-01 00:00:00pages
205-15issue
5-6eissn
0933-7407issn
1439-0507journal_volume
34pub_type
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