Protective effect of human granulocyte colony-stimulating factor (hG-CSF) on Cryptococcus and Aspergillus infections in normal and immunosuppressed mice.

Abstract:

:Prophylactic treatment with human granulocyte colony-stimulating factor (hG-CSF) affords significant protection against systemic aspergillosis or pulmonary aspergillosis in neutropenic (cyclophosphamide-treated) mice but not in cortisone-treated animals. Cryptococcosis does not respond to hG-CSF therapy. Our data show that granulocytes play an important role in the immune defense against aspergillosis, but not against cryptococcosis. Combined treatment using hG-CSF and conventional antimycotics shows a significant beneficial effect in systemic or pulmonary aspergillosis.

journal_name

Mycoses

journal_title

Mycoses

authors

Polak-Wyss A

doi

10.1111/j.1439-0507.1991.tb00645.x

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

205-15

issue

5-6

eissn

0933-7407

issn

1439-0507

journal_volume

34

pub_type

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