Abstract：
:Adenocarcinomas with intestinal differentiation have been described in a wide variety of anatomical sites. To our knowledge, however, ductal adenocarcinomas with intestinal phenotype have not been described in the pancreas. We report here 11 ductal carcinomas of the pancreas that were morphologically similar to colonic adenocarcinomas. These pancreatic carcinomas of intestinal type represented 10% of 110 consecutively removed ductal carcinomas of the pancreas. All intestinal type carcinomas expressed cytokeratin 7, carcinoembryonic antigen, CDX2, and MUC2. The pattern of reactivity of cytokeratin 7 and carcinoembryonic antigen was diffuse, whereas that of mucin 2 staining and CDX2 nuclear labeling was focal and confined predominantly to goblet cells and less frequently to columnar cells. Six carcinomas contained collections of endocrine cells admixed with the columnar and goblet cells. Five carcinomas were associated with high-grade pancreatic intraepithelial neoplasia of intestinal type. Six patients were female and 5 were male. Their ages ranged from 52 to 76 years (mean age, 61 years). The clinical presentation did not differ from that of the conventional ductal carcinomas. All carcinomas originated in the head of the pancreas, and 5 had metastasized to the regional lymph nodes at the time of surgical resection. Only 1 patient survived 5 years. Three patients are disease free from 2.8 to 8.9 months after surgery. Six patients died as a direct result of the carcinomas, and 1 was lost to follow-up. More studies are needed to determine the biologic behavior of this distinctive histologic variant of ductal adenocarcinoma of the pancreas.
journal_name
Ann Diagn Patholjournal_title
Annals of diagnostic pathologyauthors
Albores-Saavedra J,Simpson K,Dancer YJ,Hruban Rdoi
10.1016/j.anndiagpath.2006.06.008subject
Has Abstractpub_date
2007-02-01 00:00:00pages
3-9issue
1eissn
1092-9134issn
1532-8198pii
S1092-9134(06)00080-3journal_volume
11pub_type
杂志文章abstract：:Phosphaturic mesenchymal tumor (PMT) is a morphologically heterogeneous soft tissue and bone neoplasm, producing a paraneoplastic syndrome due to phosphate wasting. These tumors produce fibroblast growth factor 23, which is implicated in renal tubule phosphate loss. Medical records of patients seen from 1999 to 2013 w...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2015.08.003
更新日期：2015-12-01 00:00:00
abstract：:The aim of this prospective study is to establish the frequency and the type (neoplastic and nonneoplastic) lesions defined endoscopically as flat elevated lesion (FEL) in the colon and rectum, as well as to compare flat adenomas (FAs) to polypoid lesions of the same size with morphometric and immunohistochemical anal...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2006.03.003
更新日期：2006-12-01 00:00:00
abstract：:DOG1 is a highly-sensitive marker often included in the immunohistochemical panel for the diagnosis of gastrointestinal stromal tumors (GISTs). Recent research has shown that DOG1 may also be expressed by low-grade fibromyxoid sarcomas (LGFMSs); this may give rise to diagnostic error when the sarcoma is located in the...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1016/j.anndiagpath.2017.05.002
更新日期：2017-10-01 00:00:00
abstract：:We present the case of a patient who has a life-threatening hemoptysis caused by occlusion of the right pulmonary vein owing to external compression by excessive fibrous tissue. Because the patient's lung was essentially nonfunctional and hemoptysis persisted, we performed a pneumonectomy on her. Pathological analysis...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2005.07.006
更新日期：2005-12-01 00:00:00
abstract：:Pseudomesotheliomatous carcinoma is a rare variant of peripheral adenocarcinoma of the lung that can manifest clinical, radiologic, and pathologic features similar to malignant mesothelioma. We present three patients with pseudomesotheliomatous carcinoma of the lung. In one patient the carcinoma extended beyond the th...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/s1092-9134(99)80042-2
更新日期：1999-06-01 00:00:00
abstract：:Periumbilical skin is unique due to its proximity to intra-abdominal and pelvic structures. In addition to primary skin malignancies, it is a site often involved with metastatic disease. We reviewed the clinical and pathologic features of 77 umbilical malignancies occurring at our institution since 1988. Seventy-seven...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2010.12.004
更新日期：2011-08-01 00:00:00
abstract：:In the recent years, basaloid squamous cell carcinomas (BSCCs) have gained attention because of (1) observation of a relative increase in the number of tumors arising particularly in head and neck sites, (2) identification of human papillomavirus (HPV) in BSCCs arising predominantly in the oropharynx, and (3) controve...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1016/j.anndiagpath.2013.09.001
更新日期：2013-12-01 00:00:00
abstract：:We describe 2 cases of endobronchial pulmonary carcinoid tumor with superimposed Aspergillus colonization. The Aspergillus hyphae were associated with fibrin, ulcer debris, and granulomatous inflammation in part masking the carcinoid tumor. Presence of necrotic debris made diagnosis on biopsy difficult, and atypical c...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1016/j.anndiagpath.2011.06.005
更新日期：2013-02-01 00:00:00
abstract：:Proper interpretation of transbronchial biopsies is critical for appropriate patient management. Artifacts in lung tissue acquired during the biopsy procedure or subsequent processing may mimic "true" disease and potentially lead to incorrect diagnoses. In this study the interpretation of various artifacts in transbro...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1053/adpa.2003.50003
更新日期：2003-02-01 00:00:00
abstract：:Gastrointestinal stromal tumors are a heterogeneous group with a wide spectrum of histologic features. We describe the first case of 61-year-old woman who presented gastrointestinal stromal tumors of the ampulla of Vater with osteoclast-like giant cells surrounding osteoid-like material and aneurismal bone cyst-like a...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2012.08.003
更新日期：2013-08-01 00:00:00
abstract：:We report a case of recurrent body cavity-based non-Hodgkin's lymphoma in a patient with advanced acquired immunodeficiency syndrome who presented with bilateral pleural effusions, without evidence of an associated tumor mass. The lymphoma cells were large and pleomorphic, lacking pan-T- and pan-B-cell markers, but ex...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/s1092-9134(98)80050-6
更新日期：1998-04-01 00:00:00
abstract：:A few cases of uterine angiosarcoma have been detailed in the literature: 2 new cases are herein described featuring some unusual clinical or phenotypic differences compared with previously published cases, such as occurrence in premenopausal age or a poorly differentiated histology. The patients were 35 and 81 years ...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2007.08.001
更新日期：2008-06-01 00:00:00
abstract：:Pleomorphic stromal giant cells are occasionally found as an incidental finding in breast tissue but are only rarely seen in fibroepithelial lesions. In this report, we describe 4 fibroadenoma-like lesions of the breast with pleomorphic stromal giant cells. Two cases had focal stromal hypercellularity, one of which wa...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1016/j.anndiagpath.2009.03.007
更新日期：2009-08-01 00:00:00
abstract：AIM:Tumour-infiltrating T lymphocytes (TIL) are considered to be a reliable prognostic marker in CC, but the use in daily practice is unclear. We investigated the survival effect of TIL methodologically in a highly homogeneous population. METHODS:Seventy-two stage IIA (T3N0) CC patients who underwent surgical resectio...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2019.05.007
更新日期：2019-08-01 00:00:00
abstract：:Inflammatory pseudotumor (IPT) (also known as inflammatory myofibroblastic tumor) is an uncommon spindle cell lesion that was initially recognized in the lung and is now known to occur in virtually every major organ of the body. Its precise biological nature and clinical characteristics are still relatively uncertain....
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1053/adpa.2002.32380
更新日期：2002-04-01 00:00:00
abstract：:Cribriform areas are common features of both adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Both are malignant salivary gland tumors that share similar histologic patterns, but with marked distinct clinical behavior. This study was undertaken to improve the accuracy of the histopathology diagnosti...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1053/adpa.2001.29339
更新日期：2001-12-01 00:00:00
abstract：:Three cases of cutaneous pseudosarcomatous polyp, a lesion recently described in the dermatopathology literature, are reported here. These benign proliferations display dramatic cytologic pleomorphism, but despite their disquieting morphological features, they have behaved in a benign fashion to date. All 3 lesions in...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2007.05.004
更新日期：2008-12-01 00:00:00
abstract：:Sclerosing mediastinitis (SM) is an aggressive fibroproliferative process in the mediastinum that may lead to encasement of mediastinal structures within a dense fibrotic mass. This disease may cause significant clinical complications, morbidity, and even mortality. The etiology and pathogenesis of SM is unclear and i...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2017.01.004
更新日期：2017-04-01 00:00:00
abstract：:The ventricular assist device (VAD) is a mechanical pump that has been shown to be an effective modality of cardiac support in patients with heart failure refractory to pharmacologic intervention and who are awaiting cardiac allograft transplantation. Neuropathologic findings in these patients have not been well descr...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1053/adpa.2001.23019
更新日期：2001-04-01 00:00:00
abstract：:The urinary bladder may be involved by a variety of secondary tumors that originate from other organs. Bladder secondary tumors are rare and may be mistaken as bladder primary tumors because of their overlapping morphologic features. To avoid the diagnostic pitfalls, we analyzed the clinicopathologic features of bladd...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2020.151593
更新日期：2020-10-01 00:00:00
abstract：:The purpose of the study is to assess whether a protocol for submitting clinically suspected endometrial polyps will improve the detection rate of polyps and evaluation of the background endometrium. A retrospective review from 1999 to 2015 was performed. Cases were divided into (1) polyps and curettings placed in 2 c...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2016.05.002
更新日期：2016-08-01 00:00:00
abstract：:Intradiploic inclusion cyst of the skull presenting as a calvarial defect is fairly uncommon in the neuroscience practice. They are benign in nature, slow to grow, and clinically difficult to differentiate from other causes of calvarial defects. We present a case of a healthy 55-year-old woman who presented clinically...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2005.07.007
更新日期：2006-02-01 00:00:00
abstract：:Recurrences of nonmuscle-invasive urothelial bladder cancer are very common following resection. Predictive histopathologic variables in transurethral resection of bladder tumor (TURBT) specimens are of particular importance especially in determining the behavior of lamina propria-invasive tumors (high grade T1 stage)...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2013.11.002
更新日期：2014-04-01 00:00:00
abstract：:Spindle cell tumors of the prostate are rare and mostly primary. We report a case of retroperitoneal sarcoma, which is a low-grade fibromyxoid sarcoma involving the prostate secondarily by metastasis. The patient was a 44-year-old man who presented with progressing abdominal pain. Computed tomography showed a large re...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2010.01.001
更新日期：2011-02-01 00:00:00
abstract：INTRODUCTION:Hydatid disease is an endemic parasitic infection caused by Echinococcus granulosus mostly seen in the Mediterranean countries. The most affected organ is the liver, however hydatidosis can be found anywhere in the human body. METHODS:The records of patients who were diagnosed with hydatid disease in our ...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2017.01.011
更新日期：2017-08-01 00:00:00
abstract：:Endometrial stromal tumors (ESTs) of the uterine corpus have a striking propensity to display diverse morphological variations, including sex cord-like, smooth muscle, or skeletal muscle differentiation; fibrous change; myxoid change; or bland endometrioid-type glands. They may also contain rhabdoid, foam, clear, or e...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2005.03.002
更新日期：2005-06-01 00:00:00
abstract：:Myoid angioendothelioma of the spleen is an uncommon, benign vascular tumor that is morphologically characterized by a composite of vascular spaces and stromal cells with myoid feature. Herein, we report a case of the myoid angioendothelioma of the spleen, concurrent with rectal adenocarcinoma. A 41-year-old woman pre...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2012.03.001
更新日期：2013-02-01 00:00:00
abstract：:A total of sixty samples from human breast, uterus, liver, skin and abdominal fat were fixed for 8; 24 and 48 hours at a room temperature of 20 to 22°C with neutral buffered formalin (NBF) with volume to tissue ratios of 1:1; 2:1; 5:1 and 10:1 and manually processed with isopropyl alcohol and mineral oil mixtures. All...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2011.12.003
更新日期：2012-06-01 00:00:00
abstract：:Pancreatic ectopia in the mediastinum is rare, and there are no reports that it has ever given rise to malignancy. Here we report a case of adenocarcinoma arising in ectopic pancreatic tissue in the mediastinum of a 66-year-old woman. The tumor arose in a partially cystic and partially solid ectopic pancreas containin...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1016/j.anndiagpath.2011.04.005
更新日期：2012-12-01 00:00:00
abstract：:To test the hypothesis of whether cellular blue nevi (CBN) may originate from "ordinary" compound and dermal nevi, a total of 275 melanocytic nevi including 59 CBN, 34 ordinary blue nevi, 87 combined nevi (including 43 so-called clonal nevi), 35 deep penetrating nevi, and 60 ordinary compound and dermal nevi (30 of ea...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2007.03.001
更新日期：2007-06-01 00:00:00
