Abstract：
:The inferior olive (IO) is a required component of neural circuits controlling the classical conditioning of eyeblink responses. Previous reports indicated that lesioning or inactivating the IO abolishes conditioned eyeblinks (CRs), but there was disagreement regarding the timing of the CR performance deficit. As a result, it was not clear whether IO inactivation produces unlearning of CRs or a non-specific dysfunction of cerebellar circuits. Since most of these studies used methods that could block unrelated axons passing through the IO region, additional experiments are required to further elucidate IO function, using inactivating agents that act selectively on cell bodies. In the present study, the IO was inactivated using the glutamate receptor antagonist DGG and the GABA-A receptor agonist muscimol in rabbits performing well-learned CRs. Effects of inactivating the IO on CR expression and on neuronal activity in the anterior cerebellar interposed nucleus (IN) were examined. We found that either blocking excitatory glutamate inputs or activating inhibitory GABA inputs to the IO abolished CRs. This effect occurred with variable delay following drug injections. Additional experiments, in which post-injection testing was delayed to allow for drug diffusion, revealed invariably immediate suppression of CRs. This demonstrated that suppressing IO activity using DGG or muscimol does not induce unlearning of CRs. Single-unit recording during DGG injections revealed that CR suppression was paralleled by a dramatic suppression of IN neuronal activity. We concluded that inactivating the rostral parts of the IO complex abolishes CRs by producing a tonic malfunction of cerebellar eyeblink conditioning circuits.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Zbarska S,Holland EA,Bloedel JR,Bracha Vdoi
10.1016/j.bbr.2006.12.012subject
Has Abstractpub_date
2007-03-12 00:00:00pages
128-38issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(06)00705-4journal_volume
178pub_type
杂志文章abstract：:Diabetes mellitus is associated with disturbances of cognitive functioning. The aim of this study was to examine cognitive functioning in diabetic rats using the 'Can test', a novel spatial/object learning and memory task, without the use of aversive stimuli. Rats were trained to select a single rewarded can from seve...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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pub_type： 杂志文章,评审
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：1995-01-23 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.06.036
更新日期：2009-12-14 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(90)90066-n
更新日期：1990-02-12 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.11.016
更新日期：2006-04-03 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bbr.2009.09.011
更新日期：2010-01-20 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.12.010
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更新日期：2006-08-10 00:00:00
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更新日期：2004-11-05 00:00:00
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