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Endophthalmitis after uncomplicated cataract surgery with the use of fourth-generation fluoroquinolones: a retrospective observational case series.

Abstract：

OBJECTIVE:To estimate the rate of acute postoperative endophthalmitis after uncomplicated cataract surgery in patients treated before and after surgery with 1 of 2 different fourth-generation fluoroquinolone ophthalmic drops for surgical prophylaxis. DESIGN:Retrospective, multicenter, observational case series. PARTICIPANTS:Included in this study were 20,013 patients from 9 cataract surgery centers in 7 states in the United States. METHODS:Patients who had undergone uncomplicated phacoemulsification who received preoperative and postoperative topical fourth-generation fluoroquinolones for surgical prophylaxis between March 2003 and July 2005 were included in the study. The files of patients in whom acute endophthalmitis developed were reviewed and analyzed. MAIN OUTCOME MEASURES:Number and rate of endophthalmitis cases after uncomplicated cataract surgery. RESULTS:During the study period, the participating surgeons performed 20,013 uncomplicated surgeries. Of these, 16,209 patients (81%) received topical gatifloxacin and 3804 patients (19%) were treated with topical moxifloxacin as antiinfective prophylaxis. A total of 14 patients experienced endophthalmitis. The overall rate of endophthalmitis was 0.07%. There were 9 endophthalmitis patients in the gatifloxacin group and 5 endophthalmitis patients in the moxifloxacin group. The rate of endophthalmitis in the gatifloxacin group was 0.06% and the rate in the moxifloxacin group was 0.1%. The difference in the rate of endophthalmitis between the 2 groups was not statistically significant. In 10 of the patients, vitreous culture results were positive. Coagulase-negative staphylococci, followed by streptococci, species were the most commonly isolated organisms in the culture-positive patients. CONCLUSIONS:The overall rate of endophthalmitis after uncomplicated cataract surgery in patients treated with topical fourth-generation fluoroquinolones as antiinfective prophylaxis was 0.07%. This rate was within the range of previously reported rates of endophthalmitis in the literature. The difference in the observed rate of postoperative endophthalmitis in patients treated with moxifloxacin versus gatifloxacin was not statistically significant.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Moshirfar M,Feiz V,Vitale AT,Wegelin JA,Basavanthappa S,Wolsey DH

doi

10.1016/j.ophtha.2006.08.038

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

686-91

issue

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(06)01208-5

journal_volume

114

pub_type

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Endophthalmitis after uncomplicated cataract surgery with the use of fourth-generation fluoroquinolones: a retrospective observational case series.