Abnormal asymmetric dimethylarginine/nitric oxide balance in patients with documented coronary artery disease: relation to renal function and homocysteine.


BACKGROUND:As an endogenous inhibitor of nitric oxide production, asymmetric dimethylarginine (ADMA) is reported to be associated with coronary artery disease (CAD). METHODS:We measured plasma levels of ADMA, nitrate + nitrite (NOx), total homocysteine (tHCY), and renal function in 106 people with angiographic evidence of coronary artery disease (CAD), including 46 with single vessel disease and 60 with double/triple vessel disease, and in 70 age-matched individuals without any angiography evidence of CAD. Also the levels of these parameters were evaluated according to their history of MI. Plasma tHcy and ADMA were measured by HPLC and the levels of NOx using the Griess reaction. RESULTS:Levels of ADMA, ACE and tHcy levels were significantly higher and NO level was significantly lower in CAD patients compared with controls but there were no significant differences among patients with or without history of MI and between patients with single compared to those with double/triple vessel disease. Additionally a negative correlation was found between ADMA-NOx (r = -0.396, p = 0.001) and between tHcy-NOx (r = -0.262, p = 0.027). In the entire study group, ADMA level was significantly higher in patients with creatinine clearance (CrCl) < 91 mL/min than in patients with CrCl > or = 91 mL/min (0.60 +/- 0.23 micromoles/L versus 0.49 +/- 0.25 micromoles/L, p = 0.05). CONCLUSIONS:We suggest that there is an abnormal plasma ADMA-to-NO balance in patients with documented CAD and that this may be due at least in part to an associated reduction in renal function.


J Thromb Thrombolysis


Ilhan N,Seckin D,Ilhan N,Ozbay Y




Has Abstract


2007-06-01 00:00:00












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    abstract::Drug-eluting stents (DES) reduce the incidence of in-stent restenosis (ISR) after primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). Whether the use of biomarkers might be of utility to identify patients who remain at risk for DES ISR after primary PCI has never been exami...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Claessen BE,Stone GW,Mehran R,Witzenbichler B,Brodie BR,Wöhrle J,Witkowski A,Guagliumi G,Zmudka K,Henriques JP,Tijssen JG,Sanidas EA,Chantziara V,Hakim D,Leon S,Xu K,Dangas GD

    更新日期:2012-08-01 00:00:00

  • Interhospital transfer on intravenous thrombolysis in patients with acute ischemic stroke in three chinese municipal stroke centers.

    abstract::We included acute ischemic stroke (AIS) patients who received recombinant tissue plasminogen activator (rt-PA) at three stroke centers via either interhospital transfer or direct presentation and compared the clinical outcomes and time metrics to analyze the impact of interhospital transfer on intravenous thrombolysis...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,多中心研究


    authors: Ding Y,Ji Z,Ma L,Zhai T,Gu Z,Niu J,Liu Y

    更新日期:2019-11-01 00:00:00

  • Molecular pathogenesis of plasminogen Hakodate: the second Japanese family case of severe type I plasminogen deficiency manifested late-onset multi-organic chronic pseudomembranous mucositis.

    abstract::A 64-year-old man first developed ligneous conjunctivitis at the age of 58 years after right pulmonary resection because of suspected cancer; otherwise, he had been healthy. Since then, he began to suffer from various forms of chronic pseudomembranous mucositis. Laboratory tests demonstrated that he had 7.8 % of plasm...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Osaki T,Souri M,Song YS,Izumi N,Law R,Ichinose A

    更新日期:2016-08-01 00:00:00

  • The effect of cessation of 2nd generation P2Y12 inhibitor therapy on platelet reactivity in patients 1 year after acute myocardial infarction.

    abstract::To assess the effect of cessation of dual antiplatelet therapy (DAPT) regimens containing 2nd generation P2Y12 inhibitors on platelet reactivity, in patients who completed 12 months of DAPT following an acute myocardial infarction. Clinical data has shown an increased cardiovascular risk in the 90 days following cessa...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Witberg G,Bathish J,Bental T,Leshem-Lev D,Assali A,Kornowski R,Lev E

    更新日期:2018-10-01 00:00:00

  • Acute ischemic stroke patients with diabetes should not be excluded from intravenous thrombolysis.

    abstract::The benefit of intravenous thrombolysis (IVT) has been questioned for patients with diabetes mellitus (DM) in cases of acute ischemic stroke (IS). Our objective was to analyze the differences in outcome according to prior diagnosis of DM and the use or not of IVT. Observational study with inclusion of consecutive IS p...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Fuentes B,Cruz-Herranz A,Martínez-Sánchez P,Rodríguez-Sanz A,Ruiz Ares G,Prefasi D,Sanz-Cuesta BE,Lara-Lara M,Díez-Tejedor E

    更新日期:2014-11-01 00:00:00

  • Vincristine induces procoagulant activity of the human lymphoblastic leukemia cell line Jurkat through the release of extracellular vesicles.

    abstract::Thromboembolic events are frequent and serious complications of acute lymphoblastic leukaemia treatment. The importance of chemotherapy in the pathogenesis of this increased risk is enhanced by the fact that thrombosis rarely occurs at diagnosis. Our study aims at investigating the effect of chemotherapy on pro-coagul...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Pluchart C,Poitevin G,Colinart-Thomas M,Guimard G,Audonnet S,Terryn C,Nguyen P

    更新日期:2019-08-01 00:00:00

  • Reducing catheter-related thrombosis using a risk reduction tool centered on catheter to vessel ratio.

    abstract::In vascular access practices, the internal vessel size is considered important, and a catheter to vessel ratio (CVR) is recommended to assist clinicians in selecting the most appropriate-sized device for the vessel. In 2016, new practice recommendations stated that the CVR can increase from 33 to 45% of the vessels di...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Spencer TR,Mahoney KJ

    更新日期:2017-11-01 00:00:00

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    abstract::Sickle cell disease (SCD) is characterised by abnormal coagulopathy and angiogenesis although their relationships in two common genotypes, homozygous (HbSS) SCD and sickle-haemoglobin C disease (HbSC), are unexplored. We measured markers of platelet activation (soluble P-selectin [sP-selectin]), fibrinolysis (D-dimer)...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Blann AD,Mohan JS,Bareford D,Lip GY

    更新日期:2008-04-01 00:00:00

  • Awareness and management of pulmonary embolism among physicians in China: a nationwide cross-sectional study.

    abstract::Pulmonary embolism (PE) is a leading cause of cardiovascular mortality. We intended to evaluate the awareness and management status of PE among Chinese physicians and provide the basis for establishing Chinese clinical guidelines on PE. We designed a nationwide survey to collect data on physicians' awareness of diagno...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Zhang M,Zhang YX,Zhang Z,Wang J,Shao X,Xie WM,Wan J,Zhai ZG,Wang C

    更新日期:2019-04-01 00:00:00

  • Polymorphism induced sensitivity to warfarin: a review of the literature.

    abstract::Warfarin is a widely prescribed anticoagulant used for prophylaxis and treatment of venous and arterial thrombosis. Although warfarin is considered very efficacious, it has substantial risks associated with its use, specifically the risk of hemorrhage. Genetic variants associated with the metabolism of (S)-warfarin by...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Palkimas MP Jr,Skinner HM,Gandhi PJ,Gardner AJ

    更新日期:2003-06-01 00:00:00

  • Thrombolytic effect of subtilisin QK on carrageenan induced thrombosis model in mice.

    abstract::Subtilisin QK, a new fibrinolytic enzyme, could cleave directly cross-linked fibrin in vitro. To verify the thrombolytic function of Subtilisin QK in vivo, the thrombolytic effect of purified Subtilisin QK on tail-thrombus of mouse was investigated. After injected with carrageenan, the tail-thrombus of Subtilisin QK t...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Yan F,Yan J,Sun W,Yao L,Wang J,Qi Y,Xu H

    更新日期:2009-11-01 00:00:00

  • Venous thromboembolism: patient awareness and education in the pre-operative assessment clinic.

    abstract::Each year venous thromboembolism (VTE) causes up to 60,000 deaths in the UK, many resulting from hospital-acquired thromboses following elective surgery. National Institute for Health and Clinical Excellence (NICE) guidelines state that all elective surgical patients should receive verbal and written information pre-o...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 临床试验,杂志文章


    authors: Haymes A

    更新日期:2016-04-01 00:00:00

  • Association between TLR9 rs5743836 polymorphism and risk of recurrent venous thromboembolism.

    abstract::Recent gene knockout studies on mice have shown the role of toll-like receptor 9 (TLR9) in resolution of venous thromboembolism (VTE) through sterile inflammation. However, the role of a putative functional TLR9 polymorphism (rs5743836) in risk assessment of VTE recurrence remains unknown. The aim of our study was to ...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Ahmad A,Sundquist K,Zöller B,Svensson PJ,Sundquist J,Memon AA

    更新日期:2017-07-01 00:00:00

  • Resolution of acute lower extremity deep vein thrombosis with rivaroxaban compared to warfarin.

    abstract::Thrombosis resolution is an important component of treatment for deep vein thrombosis (DVT) and multiple anticoagulants are now available. It is unknown whether rivaroxaban contributes to a higher degree of thrombus resolution compared to conventional anticoagulation with warfarin. Our objective was to compare thrombu...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Houghton DE,Lekah A,Macedo TA,Hodge D,Saadiq RA,Little Y,Casanegra AI,McBane RD,Wysokinski WE

    更新日期:2020-02-01 00:00:00

  • Effect of taurine on endotoxin-induced alterations in plasma asymmetric dimethylarginine, L-arginine and nitric oxide in guinea pigs.

    abstract::The effect of taurine on the plasma levels of L-arginine, asymmetrical dimethylarginine (ADMA) and L-arginine/ADMA ratio and nitric oxide was investigated in experimental endotoxemia. L-arginine and ADMA levels were quantified by high performance liquid chromatography with fluorescence detector. Nitric oxide level was...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Balabanli B,Erdamar H,Türközkan N,Yaman H,Kurt Y

    更新日期:2007-08-01 00:00:00

  • Acute Ethanol Does Not Protect Against Ischemic/Reperfusion Injury in Rabbit Myocardium.

    abstract::Moderate use of alcohol has shown protective effects in coronary artery disease, while excessive use has been associated with cardiomyopathy and hypertension. Since alcohol is a vasodilator, we postulated that it might have protective effects when administered acutely in the setting of ischemia/reperfusion. Therefore,...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Bellows SD,Hale SL,Kloner RA

    更新日期:1996-01-01 00:00:00

  • Antithrombotic therapy for chronic coronary syndrome and atrial fibrillation: less might be more.

    abstract::The best strategy in atrial fibrillation (AF) after > 12 months after an acute coronary syndrome or in patients with chronic coronary syndrome without an indication for interventional revascularization remains unclear. European guidelines generally recommend therapy with oral anticoagulation (OAC) alone, whereas North...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,meta分析


    authors: Wernly B,Bhatt DL,Polzin A,Jung C

    更新日期:2020-02-01 00:00:00

  • Exposure to platelets promotes functional properties of endothelial progenitor cells.

    abstract::Recent evidence indicates that endothelial progenitor cells (EPCs) have an important role in the process of repair following vascular injury, and that platelets mediate their recruitment to sites of injury. Platelets and EPCs can interact and bind directly. However, there is limited information on the effect of platel...

    journal_title:Journal of thrombosis and thrombolysis

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    authors: Leshem-Lev D,Omelchenko A,Perl L,Kornowski R,Battler A,Lev EI

    更新日期:2010-11-01 00:00:00

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    abstract::Several newer anticoagulants are under clinical development. Recently two of them, Dabigatran etexilate/Pradaxa. and Rivaroxaban/Xarelto obtained marketing authorization in Europe and Canada for the prevention of thromboembolic events following major orthopedic surgery such as total hip and knee replacement. The resul...

    journal_title:Journal of thrombosis and thrombolysis

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  • Early changes in local hemostasis activation following percutaneous coronary intervention in stable angina patients: a comparison between drug-eluting and bare metal stents.

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    authors: Mahemuti A,Meneveau N,Seronde MF,Schiele F,Descotes-Genon V,Ecarnot F,Blonde MC,Mercier M,Racadot E,Bassand JP

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  • Risk factors for pulmonary embolism in patients preliminarily diagnosed with community-acquired pneumonia: a prospective cohort study.

    abstract::D-dimer levels are increased in patients with acute pulmonary embolism (PE). However, D-dimer levels are also increased in patients with community-acquired pneumonia (CAP). The aim of this prospective cohort study was to examine the incidence and clinical features of patients preliminarily diagnosed with CAP and with ...

    journal_title:Journal of thrombosis and thrombolysis

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    authors: Zhang Y,Zhou Q,Zou Y,Song X,Xie S,Tan M,Zhang G,Wang C

    更新日期:2016-05-01 00:00:00

  • Platelet response to direct thrombin inhibitor or fondaparinux treatment in patients with suspected heparin-induced thrombocytopenia.

    abstract::Making a definitive diagnosis of heparin-induced thrombocytopenia (HIT) can be problematic. A prompt platelet rise following treatment has been proposed as a "post-test" criterion for diagnosis. However, the platelet response following discontinuation of heparin and initiation of a recommended alternative anticoagulan...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,多中心研究


    authors: Pon TK,Mahajan A,Rosenberg A,Amin A,Shah D,Jenkins I,Gupta V,Hofmann H,Bejjani A,White R

    更新日期:2018-05-01 00:00:00

  • Randomized, Placebo-Controlled Study of Lamifiban with Thrombolytic Therapy for the Treatment of Acute Myocardial Infarction: Rationale and Design for the Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion Gain in Myocardial Infar

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    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Moliterno DJ,Harrington RA,Califf RM,Rapold HJ,Topol EJ

    更新日期:1995-01-01 00:00:00

  • Thrombolysis with streptokinase during cardiopulmonary resuscitation: a single center experience and review of the literature.

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    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Aliyev F,Habeb M,Babalik E,Karadag B

    更新日期:2005-12-01 00:00:00

  • Association of TIMI myocardial perfusion grade and ST-segment resolution with cardiovascular magnetic resonance measures of microvascular obstruction and infarct size following ST-segment elevation myocardial infarction.

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    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Appelbaum E,Kirtane AJ,Clark A,Pride YB,Gelfand EV,Harrigan CJ,Kissinger KV,Manning WJ,Gibson CM

    更新日期:2009-02-01 00:00:00

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    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,随机对照试验


    authors: Welsby IJ,Phillips-Bute B,Mathew JP,Newman MF,Becker R,Rao S,Milano CA,Stafford-Smith M

    更新日期:2014-10-01 00:00:00

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    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Paul M,Thushara RM,Jagadish S,Zakai UI,West R,Kemparaju K,Girish KS

    更新日期:2017-02-01 00:00:00

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    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 已发布勘误


    authors: Ito Y,Noguchi K,Morishima Y,Yamaguchi K

    更新日期:2018-01-01 00:00:00

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    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Levine GN,Hochman JS

    更新日期:1995-01-01 00:00:00

  • Circulating p53 and cytochrome c levels in acute myocardial infarction patients.

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    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Dincer Y,Himmetoglu S,Bozcali E,Vural VA,Akcay T

    更新日期:2010-01-01 00:00:00