Abstract:
INTRODUCTION:Inhaled beta2-agonists are important therapeutic agents for the treatment of exercise-induced asthma in athletes but are restricted by international antidoping regulations. PURPOSE:To investigate whether 18 mug of inhaled formoterol affects endurance performance during running at high altitudes until exhaustion among 20 nonasthmatic male athletes aged 21-35 yr. METHODS:: In a randomized, double-blind, placebo-controlled crossover study, the athletes performed one screening test and two similar performance tests. Each performance test consisted of 20 min of warm-up and a running test until exhaustion, which lasted 210-300 s in hypobaric conditions equal to 2000 m above sea level. Maximal oxygen consumption (VO2max) and peak ventilation (VEpeak) were measured during running, and pulmonary function was measured before and after exercise. The screening test was used to determine running speed on days 2 and 3, with inhaled formoterol or placebo in a randomized manner before exercise. VO2, VE, arterial oxyhemoglobin saturation (SPO2), and heart rate (HR) were measured during exercise, and maximum plasma lactate concentration was measured after exercise. RESULTS:Inhaled formoterol did not improve running time to exhaustion, VO2, VE, SPO2, or HR (P > 0.05) in hypobaric conditions compared with placebo, although formoterol significantly improved lung function (FEV1 and FEF50) 15 and 30 min before exercise and 3, 6, 10, and 15 min after exercise. CONCLUSIONS:Inhaled formoterol did not improve endurance performance in healthy nonasthmatic athletes at hypobaric conditions equal to 2000 m above sea level. Inhaled formoterol can thus be used by asthmatic athletes in sports under extreme conditions.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Riiser A,Tjørhom A,Carlsen KHdoi
10.1249/01.mss.0000233801.46906.9bsubject
Has Abstractpub_date
2006-12-01 00:00:00pages
2132-7issue
12eissn
0195-9131issn
1530-0315pii
00005768-200612000-00013journal_volume
38pub_type
杂志文章,随机对照试验abstract::Previous studies have suggested that, for the same power output, arm exercise requires higher oxygen uptake (VO2), carbon dioxide output (VCO2), and ventilation (VE) than leg exercise and that response kinetics are slower. To evaluate these differences, four healthy subjects performed a total of 95 arm cranking tests....
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract:PURPOSE:The purpose of this study was to investigate the relationship between myosin heavy chain (MHC) composition and maximal contraction strength of the human quadriceps femoris muscle. METHODS:Muscle biopsies were obtained from m. vastus lateralis in your highly physical active males (N = 7). The MHC composition of...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199808000-00006
更新日期:1998-08-01 00:00:00
abstract:PURPOSE:Heart rate (HR) is widely used to adjust exercise intensity in aerobic training. Training HR recommendations are calculated often from simple equations. Because at lactate steady state (LASS) may be an intensity of exercise eliciting similar objective measures of intensity and similar subjective measures of met...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200205000-00024
更新日期:2002-05-01 00:00:00
abstract::The influence of body weight on the performance in cross-country skiing has been studied by: dimensional analysis of the ratio (R) between the factors of importance to power production (VO2max, acceleration of gravity) and the braking powers, e.g., friction and air resistance; measuring the energy cost of level skiing...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1987-08-01 00:00:00
abstract:PURPOSE:The study's purpose was to examine the effects of a short-term period with intensified training or training cessation of trained soccer players on VO(2) kinetics at 75% maximal aerobic speed, oxidative enzymes, and performance in repeated high-intensity exercise. METHODS:After the last match of the season, 18 ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318211c01a
更新日期:2011-09-01 00:00:00
abstract::The purpose of this study was to compare the rate of gastric emptying of 20 g.l-1 (2G), 40 g.l-1 (4G), and 60 g.l-1 (6G) glucose solutions with that of water (W). On separate occasions in randomized order, a 600-ml test solution was instilled into the stomach of each of six healthy male volunteers. Gastric emptying wa...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-10-01 00:00:00
abstract::Ski charging was measured using giant-slalom style skis as gliding capacitors. The voltage measured across the plates was proportional to the charge on the base. While resting on dry snow or suspended in the air, the voltage was slowly reduced by the data logger itself. On wet snow the decay was much faster. While sta...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:We aimed to evaluate in a longitudinal study the effect of intensive training on cardiac autonomic control in athletes using 24-h heart rate variability analysis. METHODS:Time and frequency domain measures of heart rate variability were calculated from 24-h Holter monitoring in 15 high level bicyclists (mean a...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199805000-00008
更新日期:1998-05-01 00:00:00
abstract::The present investigation tested the hypotheses that there would be greater prevalence of expiratory flow limitation (EFL) in endurance-trained (ET) youth cyclists compared with a recreationally active control (CON) group. METHODS:Twelve ET youth male cyclists (16.3 ± 1.0 yr (13-18 yr), 176.5 ± 6.2 cm, 64.2 ± 5.9 kg)...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002325
更新日期:2020-09-01 00:00:00
abstract::Regression analysis is often used to demonstrate associations among variables believed to be biologically related. Failure to demonstrate a "significant" relationship may be due to two factors: 1) the variables are truly unrelated, or 2) a relationship exists but goes undetected due to inadequate statistical power. In...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::Conflicting data on the alterations in the maximal exercise response to beta blockade (BB) may be the result of differences in the length of time the subject has been on medication, i.e., hours vs days. The purpose of this study was to examine maximal exercise responses during acute and chronic administration of BB. T...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1988-12-01 00:00:00
abstract::Over the course of 2 yr, we prospectively studied the effect on resting metabolic rate (RMR) of multiple cycles of weight loss followed by regain in six weight cycling collegiate wrestlers (WC) (mean age = 19.0 yr) compared with 12 weight stable, physically active, nonwrestling controls (C) (mean age = 20.9 yr), whose...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::The following paper gives a summary of the published studies that have applied the theories of reasoned action and planned behavior to the prediction of exercising intentions and behavior. The paper focuses primarily on the knowledge gained from the application of these theories and how these theoretical frameworks co...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1994-11-01 00:00:00
abstract::In a cross-sectional study, 50 elderly women (age 71.5 +/- 4.2 yr, mean +/- SD) participated in a battery of tests assessing several aspects of physical fitness. The women were selected based on tertiles of habitual physical activity as determined by a validated questionnaire 10 months ago. The tests comprised the fol...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::Acute and chronic positive mood changes have been said to occur with running and jogging. It has been suggested that endogenous substances with opioid activity (endorphins) may serve as modulators of mood. The authors report experiments in which mood changes associated with long-distance running were measured by pre- ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198201000-00002
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:To compare the effects of different patterns of regular brisk walking on fitness, risk factors for cardiovascular disease, and psychological well-being in previously sedentary adults. METHODS:Twenty-one subjects (14 women), aged 44.5 +/- 6.1 yr (mean +/- SD) were randomly assigned to two different, 6-wk progra...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00005768-200209000-00011
更新日期:2002-09-01 00:00:00
abstract:PURPOSE:beta2 adrenergic agonists are widely used as doping agents. Their side effects on bone, especially microarchitecture, remain unknown. The purpose of this study was to evaluate the effects of chronic clenbuterol and salbutamol treatment on bones of growing rats. METHODS:Twelve-week-old Wistar female rats were d...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000177592.82507.95
更新日期:2005-09-01 00:00:00
abstract::Laboratory studies using direct calorimetry, a technique which is no longer either rare or difficult, have shown no essential differences between men and women who gain weight easily and the always lean. Both groups gained weight similarly when overeating by 1,000 kcal X d-1. Thermogenic responses to eating and the en...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1986-02-01 00:00:00
abstract::The utility of a biomechanical evaluation of an injury is shown for an incident involving bilateral tibial spiral fractures during skiing. With incorporation of directly measured binding release forces into a biomechanical model, estimates of torques transmitted to the skier's leg were determined. The analysis reveale...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198104000-00007
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:The purpose of this study is to examine whether performance supercompensation during taper is maximized in endurance athletes after experiencing overreaching during an overload training (OT) period. METHODS:Thirty-three trained male triathletes were assigned to either OT (n = 23) or normal training groups (n =...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000301
更新日期:2014-09-01 00:00:00
abstract::The inheritance of cardiac changes during acute dynamic physical exercise was studied in 21 pairs of monozygotic and 12 pairs of dizygotic male twins, ages 18-31 yr. Echocardiography was performed in resting conditions and at submaximal supine bicycle exercise at a heart rate of 110 bpm. In resting conditions signific...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare the predictive accuracy of previously published skinfold (SKF) equations for estimating body density of 134 premenopausal African-American women (18 to 40 yr). METHODS:The equations cross-validated were: the sum of seven skinfolds equation (JPW7) and the sum of three sk...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199811000-00015
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:Ultraendurance exercise is steadily growing in popularity; however, the effect of increasingly prolonged durations of exercise on the vascular endothelium is unknown. The aim of this study was to characterize the effect of various ultramarathon running distances on vascular form and function. METHODS:We evalua...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002493
更新日期:2020-08-15 00:00:00
abstract:PURPOSE:The aim of this study was to investigate and improve the accuracy of accelerometer-type pedometers used by the elderly with slow walking speeds, with or without gait disorders, who do or do not use a cane. METHODS:Eighteen subjects walked with a cane (5 males, 13 females; age, 80.9 +/- 7.7 yr; height, 148.1 +/...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/01.mss.0000227641.68360.c2
更新日期:2006-09-01 00:00:00
abstract:PURPOSE:Compare the influence of the chemoreflex on heart rate (HR) and blood pressure (BP) responses between children and adults. METHODS:Seventy children (35 boys and 35 girls) and 70 adults (35 men and 35 women) performed 30% maximal voluntary contraction static handgrip exercise (SHG) for 3 min, followed by 4 min ...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/01.mss.0000155400.14813.df
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:The aim was to determine the feasibility of a 6-wk speed-based exercise program that could be used to initiate new exercise behaviors and to improve rapid movement in older adults approaching frailty. METHODS:The intervention group included 14 older adults (3 males and 11 females; mean ± SD, age = 70 ± 7.6 yr,...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000001069
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:The frequency of interruptions in sedentary time (sedentary breaks) is an aspect of sedentary behaviors that may be associated with metabolic health outcomes. The aim of this study was to describe the change in the frequency of sedentary breaks during a 10-yr period from ages 5 to 15 yr. METHODS:The longitudin...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318245ca20
更新日期:2012-06-01 00:00:00
abstract::Participation in sports in on the increase; this article addresses the intersection of sports and infectious diseases. Some infections occur with increased incidence in sports; others have an increased impact in that setting. Addressed in this article are issues of diagnosis, prevention, and management of many of thes...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-200007001-00008
更新日期:2000-07-01 00:00:00
abstract:PURPOSE:Time-resolved near-infrared spectroscopy was used to quantify tissue oxy- and deoxyhemoglobin concentrations ([HbO2] and [HbR]) and O2 saturation (stO2) in the oblique fibers of the vastus medialis muscle and brain prefrontal cortex during knee extension with and without blood flow restriction (BFR). METHODS:S...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000393
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:Previous studies have suggested that extreme endurance exercise may induce cardiac microdamage that could lead to subsequent myocardial fibrosis. Soluble suppression of tumorigenicity 2 (sST2) is a cardiac biomarker for assessment of myocardial fibrosis, inflammation, and strain. We evaluated baseline and exerc...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001806
更新日期:2019-03-01 00:00:00