Abstract:
:Mechanical deformation of a peripheral nerve can evoke action potentials in sensory and motor axons. The generation of these impulses with brief stimuli (<0.5 s) and their relationship to the deformation conditions have not been systematically studied in human subjects. Controlled compression stimuli over a range of amplitudes, durations, and loading rates were delivered to the ulnar nerve at the medial epicondyle in awake human subjects. Compound muscle action potentials were recorded from the first dorsal interosseous muscle. Subjects rated the magnitude of evoked paresthesias. Mechanically evoked motor and sensory responses varied linearly with the magnitude (P < 0.001) and rate of deformation (P < 0.01), but not the duration, and occurred only during the compression phase. Cutaneous axons had lower mechanical thresholds than motor axons. We relate these findings to the viscoelastic properties of peripheral nerves and differences in biophysical properties of cutaneous and motor axons.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Clarke EC,McNulty PA,Macefield VG,Bilston LEdoi
10.1002/mus.20701subject
Has Abstractpub_date
2007-03-01 00:00:00pages
303-11issue
3eissn
0148-639Xissn
1097-4598journal_volume
35pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract::Electrical stimulation was applied daily for 20 minutes to denervated rabbit extensor digitorum longus muscle. One group was stimulated with short tetani, another with 1-Hz frequency, using isometric contractions for both. Tetanic stimulation induced severe fibrosis and is harmful to denervated muscle. One Hertz stimu...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880100206
更新日期:1987-02-01 00:00:00
abstract::Obese individuals have slowed conduction in the median nerve across the wrist, but the mechanism for this is not established. This case-control study of 27 obese subjects and 16 thin subjects was designed to test the hypothesis that obese individuals have higher carpal canal pressures and more median nerve swelling th...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20125
更新日期:2004-10-01 00:00:00
abstract::The loss of muscle strength with aging appears to be greater in the lower than upper limbs, but strength and its neural control have never been compared in the same population of individuals in both upper and lower limbs. The aim of this study was to investigate differences between eight young (20-31 years) and eight ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20151
更新日期:2004-11-01 00:00:00
abstract:INTRODUCTION:Muscle fatigue could have a greater impact on position sense when antagonists of the movement are fatigued. Hence, this study aimed to compare the effects of antagonist and agonist exercise-induced muscle fatigue on knee joint position sense. METHODS:This within-subjects repeated-measures study included 4...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22018
更新日期:2011-08-01 00:00:00
abstract::L1 radiculopathy is very rare and difficult to diagnose with needle electromyography. A patient presented with pain and hypesthesia on the anterolateral aspect of the left thigh. Nerve conduction studies and needle electromyography were normal, except for the quadratus lumborum and iliopsoas muscles, which showed abno...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21601
更新日期:2010-04-01 00:00:00
abstract::Serum creatine kinase (CK) activity, calcium (Ca) and magnesium (Mg) contents of skeletal muscle and isolated mitochondria, as well as oxidative phosphorylation of X-linked muscular dystrophic (mdx) mice were compared with normal control animals at ages 5, 10, and 23 weeks. Serum CK is elevated in mdx mice at all ages...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880110809
更新日期:1988-08-01 00:00:00
abstract::Neuromyotonia or Isaacs' syndrome is a rare peripheral nerve hyperexcitability disorder caused by antibodies against potassium channels of myelinated axons. We present the high-density surface electromyographic (EMG) recordings of a patient with fasciculations and cramps due to neuromyotonia. To characterize the time ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20849
更新日期:2008-02-01 00:00:00
abstract::A quantitative assessment was made of the firing characteristics of repetitive axonal discharges encountered during microneurographic recordings from human peripheral nerves. Spontaneous activity was recorded from 16 single axons using tungsten microelectrodes inserted percutaneously into fascicles of the median or pe...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199804)21:4<461::aid-mus4>
更新日期:1998-04-01 00:00:00
abstract::The objectives of this study were 1) to determine the degree to which soleus motoneurons find their appropriate target following crush and transection injuries to the sciatic nerve, and 2) to determine whether repair of a transected nerve with a silicone tube leads to greater specificity of reinnervation and recovery ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199701)20:1<29::aid-mus4>3
更新日期:1997-01-01 00:00:00
abstract::Motor involvement in acute herpes zoster is considered rare, but its incidence is unknown. In a sample of 40 patients with acute herpes zoster of varying severity, an abnormal electromyogram (EMG) (fibrillation, positive waves, high-frequency discharges) was found in 21 (53%), suggesting extension of inflammation to t...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199711)20:11<1433::aid-mus
更新日期:1997-11-01 00:00:00
abstract:INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a debilitating neurologic disorder with poor survival rates and no clear biomarkers for disease diagnosis and prognosis. METHODS:We compared serum microRNA (miRNA) expression from patients with ALS with healthy controls and patients with multiple sclerosis and Alzhei...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26106
更新日期:2018-08-01 00:00:00
abstract::A 62-year-old woman with axonal Guillain-Barré syndrome developed weakness and urinary retention simultaneously. The retention failed to recover for 10 months even after she regained the ability to walk. The patient exhibited no postural hypotension. Videourodynamics showed that the retention was caused not by the bla...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20639
更新日期:2007-01-01 00:00:00
abstract::The purpose of this study was to evaluate the effects of spinal cord injury (SCI) and functional electrical stimulation (FES) of paralyzed muscles on type IV collagen content and proteins involving its degradation, which is initiated by matrix metalloproteinase (MMP)-2 and -9 and regulated by their tissue inhibitors (...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(200004)23:4<580::aid-mus18
更新日期:2000-04-01 00:00:00
abstract::A treatment has been developed to alleviate muscle weakness in murine dystrophy. Cultured myoblasts from genetically normal mouse embryos were injected into the right soleus of 20-day-old normal or dystrophic mice. Hosts and donors were immunocompatible but exhibited different genotype markers. Donor cells produced GP...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880110602
更新日期:1988-06-01 00:00:00
abstract::Our experience and review of the literature reveal that Sjogren's syndrome (SS) is an important, poorly recognized cause of peripheral neuropathy. Several forms of peripheral nerve dysfunction occur in SS including trigeminal sensory neuropathy, mononeuropathy multiplex, distal sensory neuropathy, distal sensorimotor ...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.880130703
更新日期:1990-07-01 00:00:00
abstract::Several monoclonal antibodies (mcAbs) elicited against the nicotinic acetylcholine receptor (AChR) from Torpedo react also with skeletal muscle AChR. Such mcAbs were used to define antigenic determinants on muscle AChR and to elucidate their effect on muscle AChR functions. Primary chick muscle cultures were used as a...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880060410
更新日期:1983-05-01 00:00:00
abstract::To better define electrophysiological abnormalities in myasthenia gravis (MG) patients with muscle-specific tyrosine kinase (MuSK) antibodies (Ab), we compared electrophysiological features of 14 MuSK Ab-positive, 73 acetylcholine receptor antibody (AChR Ab)-positive, and 22 MuSK and AChR Ab-negative (seronegative) pa...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20498
更新日期:2006-04-01 00:00:00
abstract::Although the effect of low temperature on the peripheral nervous system has been systematically studied, the effect of high temperature has not. We investigated the effect of elevating limb temperature from 32 degrees C to 42 degrees C by performing sequential motor studies, antidromic sensory studies, and 3-Hz repeti...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199704)20:4<431::aid-mus5>
更新日期:1997-04-01 00:00:00
abstract::Peripheral nerve lesions are sometimes associated with focal dystonia. We diagnosed ulnar neuropathy in 28 of 73 (40%) cases of occupational cramp in musicians. Focal slowing of ulnar conduction across the elbow was identified in 15 of 19 (79%) patients using the near nerve technique and in 5 of 17 (29%) patients usin...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880190403
更新日期:1996-04-01 00:00:00
abstract::Patients with chronic inflammatory demyelinating polyneuropathy (CIDP) received immune globulin intravenous, 10% caprylate/chromatography purified (IGIV-C, Gamunex; n=59) or placebo (n=58) every 3 weeks for up to 24 weeks (first period) in a randomized, double-blind, parallel-group, response-conditional, crossover stu...
journal_title:Muscle & nerve
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/mus.21236
更新日期:2009-04-01 00:00:00
abstract::The compound muscle action potential (M(MAX)) during a maximal voluntary contraction (MVC) may be measured to determine if the motor nerve has been supramaximally stimulated during the interpolated twitch technique (ITT). Ten males performed isometric knee extension MVCs. M(MAX) for the vastus medialis was recorded du...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21692
更新日期:2010-10-01 00:00:00
abstract::Acetylcholine receptor (AChR) metabolism was studied in muscle from juvenile and adult dogs with congenital myasthenia gravis (CMG) and their unaffected littermates. Although the amount of AChR in the junctional region of innervated CMG muscle fibers was 25% of normal, or less, denervation of CMG fibers resulted in th...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880070905
更新日期:1984-11-01 00:00:00
abstract::The protein compositions of subcellular fractions of muscle obtained from 17 Duchenne dystrophy patients, 15 disease controls (10 different primary myopathies, 5 spinal muscular atrophy patients), and 10 normals were examined by polyacrylamide gel electrophoresis. The gels were stained with Coomassie Brilliant Blue an...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880120404
更新日期:1989-04-01 00:00:00
abstract::The purpose of the study was to investigate differences in contractile speed, force, and fatigability of the adductor pollicis muscle between 12 patients with multiple sclerosis (MS) and 8 sedentary control subjects matched for age and gender. There were no differences between the patients with MS and control subjects...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.1129
更新日期:2001-09-01 00:00:00
abstract::Based on the known trophic effects of growth hormone (GH) on nerve and muscle 75 patients with ALS were treated for up to 18 months with synthetic human growth hormone (Protropin) or a placebo. The course of ALS was assessed serially using a quantitative (TQNE) neuromuscular and manual exam (MRC) and laboratory chemis...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/mus.880160608
更新日期:1993-06-01 00:00:00
abstract::We describe a patient who developed seropositive myasthenia gravis 16 years after she was diagnosed with autoimmune premature ovarian failure with antibodies to the receptor for follicle-stimulating hormone (FSH). Although thymectomy led to improvement of her myasthenic symptoms, menses did not resume. Such combined s...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20067
更新日期:2004-08-01 00:00:00
abstract::The goal of this study was to examine the effects of altered thyroid state and denervation (Den) on skeletal myosin heavy chain (MHC) expression in the plantaris and soleus muscles. Rats were subjected to unilateral denervation (Den) and randomly assigned to one of three groups: (1) euthyroid; (2) hyperthyroid; (3) an...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199712)20:12<1487::aid-mus
更新日期:1997-12-01 00:00:00
abstract::The aim of this study was to estimate normal jitter in voluntarily activated extensor digitorum communis (EDC) and orbicularis oculi (OOc) muscles using a disposable concentric needle electrode (CNE). The EDC of 67 normal subjects (22 males and 45 females, mean age 35.5 +/- 10.2 years) and the OOc of 50 normal subject...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21043
更新日期:2008-06-01 00:00:00
abstract::The diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) relies primarily on clinical and electrophysiologic examination, but the nerve biopsy findings may be supportive, especially in atypical cases. In order to define the usefulness of nerve biopsy in this disease, we retrospectively studied 44 cons...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.10348
更新日期:2003-04-01 00:00:00
abstract::To study noninvasively multiple descending volleys on alpha motoneurons, we used a 30-50% maximum H-reflex in the wrist flexor muscle conditioned by a subthreshold magnetic stimulus of the contralateral motor cortex as a parameter of motoneuronal excitability in seven neurologically healthy subjects. The time interval...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880160406
更新日期:1993-04-01 00:00:00