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Association of sulfonylurea receptor 1 genotype with therapeutic response to gliclazide in type 2 diabetes.

Abstract：

:To investigate the effects of sulfonylurea receptor 1 (SUR1) exon 33 (TCC-->GCC, S1369A) polymorphism on responsiveness to gliclazide. About 115 patients with type 2 diabetes were treated with gliclazide for 8 weeks. SUR1 genotypes were tested by Taqman-PCR. After gliclazide treatment, there was association between T/G polymorphism and decrease of HbA1c. G carriers were more sensitive to gliclazide and the decrease of HbA1c was more significant than TT genotype (TT, 0.76%+/-1.70%; TG+GG, 1.60%+/-1.39%, P=0.044). The polymorphism of SUR1S1369A was associated with the therapeutic efficacy of gliclazide.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Zhang H,Liu X,Kuang H,Yi R,Xing H

doi

10.1016/j.diabres.2006.10.021

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

58-61

issue

1

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(06)00492-X

journal_volume

77

pub_type

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