Bone density and markers of bone remodeling in type 1 male diabetic patients.

abstract：AIM:Hepatic insulin clearance (HIC) is important in regulating plasma insulin levels. Diminished HIC causes inappropriate hyperinsulinaemia, and both obesity and fatty liver (FL), which are known to decrease HIC, can be found either together in the same patient or on their own. The mechanism by which obesity reduces HI...

journal_title：Diabetes & metabolism

authors： Matsubayashi Y,Yoshida A,Suganami H,Ishiguro H,Yamamoto M,Fujihara K,Kodama S,Tanaka S,Kaku K,Sone H

更新日期：2018-03-01 00:00:00

abstract：AIM:Our study explored the association between subtypes of increased fat mass (with or without associated metabolic alterations) and the presence of chronic kidney disease (CKD). METHODS:In this cross-sectional survey in China, body mass index (BMI) was used to assess fat mass. Metabolically healthy was defined as no ...

journal_title：Diabetes & metabolism

authors： Chen S,Zhou S,Wu B,Zhao Y,Liu X,Liang Y,Shao X,Holthöfer H,Zou H

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:Tumor necrosis factor alpha (TNFalpha) is expressed primarily in adipocytes and elevated levels of this cytokine have been linked to obesity and insulin resistance. Several studies have shown statistical evidence of linkage between obesity and the chromosomal region encompassing the TNFalpha gene, suggesting...

journal_title：Diabetes & metabolism

authors： Zouari Bouassida K,Chouchane L,Jellouli K,Chérif S,Haddad S,Gabbouj S,Danguir J

更新日期：2004-04-01 00:00:00

abstract：:Optimal glycaemic control is necessary to prevent diabetes-related complications. An intensive treatment, which could mimic physiological insulin secretion, would be the best one. However subcutaneous insulin treatment is not physiologic and represents a heavy burden for patients with type 1 and type 2 diabetes mellit...

journal_title：Diabetes & metabolism

authors： Lassmann-Vague V,Raccah D

更新日期：2006-12-01 00:00:00

abstract：AIM:Albuminuria is the most important indicator of diabetic nephropathy (DN). Resveratrol, a natural compound found in grape skins and red wine, has antioxidant effects. This study aimed to evaluate the effects of resveratrol on DN. METHODS:In this randomized, double-blind, placebo-controlled clinical trial, 60 patien...

journal_title：Diabetes & metabolism

authors： Sattarinezhad A,Roozbeh J,Shirazi Yeganeh B,Omrani GR,Shams M

更新日期：2019-01-01 00:00:00

abstract：AIM:This study evaluated the proportions of prandial (PHG) vs fasting hyperglycaemia (FHG) over 24h in a group of patients with type 2 diabetes (overall and for Caucasian vs Asian patients), and tested the hypothesis that an insulin regimen with a prandial component allows a greater response than basal insulin at low g...

journal_title：Diabetes & metabolism

authors： Scheen AJ,Schmitt H,Jiang HH,Ivanyi T

更新日期：2015-06-01 00:00:00

abstract：:Insulin secretion from the beta-cells in the islets of Langerhans is mainly regulated by glucose entry via its transporter. The intracellular glucose metabolism induces a rise in ATP/ADP ratio which increases the degree of closure of ATP-sensitive potassium channels (K(ATP) channels), inducing a higher intracellular K...

journal_title：Diabetes & metabolism

authors： Bataille D

更新日期：2002-12-01 00:00:00

abstract：AIM:Different treatment strategies have been used to manage adolescents with poorly controlled type 1 diabetes. We investigated whether a brief elective hospital admission improves haemoglobin A(1c) (HbA(1c)) over 12 months. METHODS:We studied a retrospective cohort of adolescents with poorly controlled type 1 diabete...

journal_title：Diabetes & metabolism

authors： Millette M,Mok E,Legault L

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:The aim of the present study was to investigate insulin secretion, insulin-receptor binding and peripheral insulin sensitivity in subjects with different degrees of obesity. METHODS:36 obese subjects with normal glucose tolerance and different degrees of obesity and 40 healthy normal-weight subjects partici...

journal_title：Diabetes & metabolism

authors： Borissova AM,Tankova TI,Koev DJ

更新日期：2004-11-01 00:00:00

abstract：:In Type 1 diabetes, high circulating growth hormone (GH) in conjunction with low plasma insulin-like growth factor-I (IGF-I) is indicative of a hepatic GH-resistance profile since the liver is the main source of circulating IGF-I. The reduction in specific growth hormone binding protein (GHBP), corresponding to the ex...

journal_title：Diabetes & metabolism

authors： Hanaire-Broutin H,Sallerin-Caute B,Poncet MF,Tauber M,Bastide R,Rosenfeld R,Tauber JP

更新日期：1996-07-01 00:00:00

abstract：:Preretinal neovascularization and chronic retinal oedema are the two major sight-threatening complications that can occur during diabetic retinopathy. Ocular neovascularization is strongly associated with retinal ischaemia, and growth factors have been implicated in its pathogenesis. The ischaemic retina is assumed to...

journal_title：Diabetes & metabolism

authors： Paques M,Massin P,Gaudric A

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVES:To compare fat and carbohydrate oxidation at different exercise intensities between overweight and normal-weight subjects, in order to analyze the influence of muscular metabolic abnormalities in obese people on substrate utilization during exercise. MATERIAL AND METHODS:32 healthy sedentary overweight subj...

journal_title：Diabetes & metabolism

authors： Pérez-Martin A,Dumortier M,Raynaud E,Brun JF,Fédou C,Bringer J,Mercier J

更新日期：2001-09-01 00:00:00

abstract：:Bariatric surgery can be proposed to address severe obesity associated with comorbid conditions, when medical treatment has failed. Three surgical techniques are currently available, including 2 using coelioscopy. Short term results are encouraging regarding weight loss, which is linked with a reduction in comorbid co...

journal_title：Diabetes & metabolism

authors： Simon C

更新日期：2000-06-01 00:00:00

abstract：:Chromium is an essential nutrient involved in the metabolism of glucose, insulin and blood lipids. Suboptimal dietary intake of chromium is associated with increased risk factors associated with diabetes and cardiovascular diseases. Within the past five years, chromium has been shown to improve glucose and related var...

journal_title：Diabetes & metabolism

authors： Anderson RA

更新日期：2000-02-01 00:00:00

abstract：:This report concerns the incidence rate of insulin-dependent diabetes mellitus (IDDM) in the 0-14 year age group in Benghazi, Libya. Incidence data are based on prospective registration of patients as part of the WHO Diamond Project from 1991 to 1995. A total of 126 IDDM incident cases (73 girls, 53 boys) were identif...

journal_title：Diabetes & metabolism

authors： Kadiki OA,Roaeid RB,Bhairi AM,Elamari IM

更新日期：1998-11-01 00:00:00

abstract：:The discoveries of leptin and adiponectin were breakthroughs in the field of metabolic diseases. Adipose cells produce both proteins and release them into the circulation. Leptin acts as a fundamental signal for the brain to modulate food intake as a function of energy status. Loss of leptin function results in obesit...

journal_title：Diabetes & metabolism

authors： Guerre-Millo M

更新日期：2008-02-01 00:00:00

abstract：AIM:In this study, we examined the trends from 1995 to 2006 in cardiovascular risk factors (CVRF) in Spaniards aged 65 years or older with diabetes. METHODS:We looked at the individual data from adults aged > or =65 years from the Spanish National Health Surveys of 1995 (n=1117), 1997 (n=1111), 2001 (n=4328), 2003 (n=...

journal_title：Diabetes & metabolism

authors： Jiménez Trujillo I,Jiménez García R,Vazquez-Fernandez del Pozo S,Hernández Barrera V,Carrasco Garrido P,Suarez P,Gil de Miguel A

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that HbA1c is an important predictor of the glycometabolic state of patients admitted for acute myocardial infarction (AMI). OBJECTIVE:We aimed at comparing the results of HbA1c concentrations obtained by 2 different methods in patients with AMI. RESEARCH DESIGN AND METHODS:In a firs...

journal_title：Diabetes & metabolism

authors： Hadjadj S,Duengler F,Barriere M,Mauco G,Coisne D,Warnier F,Sosner P,Torremocha F,Herpin D,Marechaud R

更新日期：2005-06-01 00:00:00

abstract：:Glycohaemoglobin, and particularly haemoglobin A1c(HbA1c), assays have been used for many years to retrospectively evaluate the glycaemic control of diabetic patients. Cut-off values have been established for deciding treatment modifications. The techniques used in the laboratories however exhibit varying quality, and...

journal_title：Diabetes & metabolism

authors： Gillery P,Bordas-Fonfrède M,Chapelle JP,Drouin P,Hue G,Lévy-Marchal C,Périer C,Sélam JL,Slama G,Thivolet C,Vialettes B

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between CRP levels and the components of MS in normal glucose tolerant (NGT), impaired glucose tolerant (IGT), and Type 2 diabetic subjects. MATERIAL AND METHODS:A based cross-sectional population study was performed. Eligible subjects, men and non-pregnant women, 30 to 64 year ...

journal_title：Diabetes & metabolism

authors： Guerrero-Romero F,Rodríguez-Morán M

更新日期：2003-02-01 00:00:00

abstract：AIM:To explore the frequency of hypoglycaemic episodes, their risk factors, and associations with patient-reported outcomes in patients with type 2 diabetes enrolled in the PANORAMA cross-sectional study. METHODS:Five thousand seven hundred and eighty-three patients aged ≥ 40 years with type 2 diabetes duration ≥ 1 ye...

journal_title：Diabetes & metabolism

authors： Simon D,de Pablos-Velasco P,Parhofer KG,Gönder-Frederick L,Duprat Lomon I,Vandenberghe H,Eschwège E,Bradley C

更新日期：2015-12-01 00:00:00

abstract：:The effect of propranolol on the occurrence of hypoglycaemic symptoms was assessed in insulin-dependent diabetic patients with hypoglycaemia unawareness. A double-blind, randomised parallel group study (2:1 fashion) was conducted over 4-week period. The propranolol group (n = 9) received 20 mg (week 1 and 2) and 30 mg...

journal_title：Diabetes & metabolism

authors： Chalon S,Berlin I,Sachon C,Bosquet F,Grimaldi A

更新日期：1999-03-01 00:00:00

abstract：AIM:To evaluate the correspondence between first-trimester fasting glycaemia and the results of the OGTT in diagnosing gestational diabetes (GDM). METHODS:The medical records of all consecutive women who had undergone a diagnostic OGTT, performed according to the IADPSG, during the past year were retrospectively revie...

journal_title：Diabetes & metabolism

authors： Corrado F,D'Anna R,Cannata ML,Interdonato ML,Pintaudi B,Di Benedetto A

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To determine the utility of the continuous glucose monitoring system (CGMS) as an outpatient procedure to improve management of diabetes in adolescents. RESEARCH DESIGN AND METHODS:Twelve adolescents (mean age: 16.2 +/- 3 years) with poorly controlled type 1 diabetes (HbA(1c) > 8%) were included in this tria...

journal_title：Diabetes & metabolism

authors： Schaepelynck-Bélicar P,Vague P,Simonin G,Lassmann-Vague V

更新日期：2003-12-01 00:00:00

abstract：:Many studies have demonstrated the metabolic efficacy of continuous subcutaneous insulin infusion (CSII) and particularly a reduction of glycaemic fluctuations in type 1 diabetic patients. Despite this benefit, many patients decide to discontinue the use of CSII. To determine the factors related to discontinuation of ...

journal_title：Diabetes & metabolism

authors： Ronsin O,Jannot-Lamotte MF,Vague P,Lassman-Vague V

更新日期：2005-02-01 00:00:00

abstract：AIMS:Reactive dicarbonyl compounds, such as methylglyoxal (MGO), rise during an oral glucose tolerance test (OGTT), particularly in (pre)diabetes. Fasting MGO levels are associated with chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with poorly controlled type 2 diabetes mellitus (T2DM). Yet,...

journal_title：Diabetes & metabolism

authors： Hanssen NMJ,Scheijen JLJM,Houben AJHM,van de Waarenburg M,Berendschot TTJM,Webers CAB,Reesink KD,van Greevenbroek MMJ,van der Kallen C,Schaper NC,Schram MT,Henry RMA,Stehouwer CDA,Schalkwijk CG

更新日期：2020-02-10 00:00:00

abstract：CONTEXT:In 2001 the "National Cholesterol and Education Program Expert Panel" gave a clinical definition of the metabolic syndrome. The frequency of this syndrome at baseline and its incidence and persistence at three years is studied in a French population. SUBJECTS:2109 men and 2184 women from the D.E.S.I.R. longitu...

journal_title：Diabetes & metabolism

authors： Balkau B,Vernay M,Mhamdi L,Novak M,Arondel D,Vol S,Tichet J,Eschwège E,D.E.S.I.R. Study Group.

更新日期：2003-11-01 00:00:00

abstract：AIMS:To report changes in liver function tests observed with canagliflozin, a sodium glucose co-transporter 2 inhibitor, across phase 3 studies in patients with type 2 diabetes, and to examine the relationship between changes in liver function tests and the weight loss and glycaemic improvements observed with canaglifl...

journal_title：Diabetes & metabolism

authors： Leiter LA,Forst T,Polidori D,Balis DA,Xie J,Sha S

更新日期：2016-02-01 00:00:00

abstract：:The project to finalize a 'closed loop' insulin delivery according to blood glucose level, i.e. an implanted artificial beta cell, is born from the development of the first miniaturized portable insulin pumps during the 1970s. Continuous improvements in micro-electronics, as well as in the development of biomaterials ...

journal_title：Diabetes & metabolism

authors： Renard E,Costalat G,Bringer J

更新日期：2002-09-01 00:00:00

abstract：:Protease inhibitor treatment has dramatically improved rates of morbidity and mortality in HIV-infected patients. However, it has recently been shown that this medication is associated with long-term side effects characterized by metabolic, clinical and biological alterations. These modifications have been described i...

journal_title：Diabetes & metabolism

authors： Vigouroux C,Gharakhanian S,Salhi Y,Nguyên TH,Adda N,Rozenbaum W,Capeau J

更新日期：1999-11-01 00:00:00