Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.

Abstract:

BACKGROUND:Intestinal metaplasia (IM) is an important precursor lesion in the development of gastric cancer (GC). The aim of this study was to investigate genetic factors previously linked to GC risk for their possible association with IM. A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-Chinese population at high risk of developing GC. METHODS:Genotype frequencies were compared between individuals presenting with (n = 128) or without (n = 246) IM by both univariate and multivariate analysis. RESULTS:Carriers of the NQO1 609 T allele showed an association with IM in individuals who were seropositive for Helicobacter pylori (HP+; OR = 2.61, 95%CI: 1.18-5.80, P = .018). The IL-10 819 C allele was also associated with IM in HP+ individuals (OR = 2.32, 95%CI: 1.21-4.43, P = 0.011), while the PTPN11 A allele was associated with IM in HP- individuals (OR = 2.51, 95%CI: 1.16-5.40, P = 0.019), but showed an inverse association in HP+ subjects (OR = 0.46, 95%CI: 0.21-0.99, P = 0.048). CONCLUSION:Polymorphisms in NQO1, IL-10 and PTPN11, in combination with HP status, could be used to identify individuals who are more likely to develop IM and therefore GC.

journal_name

BMC Gastroenterol

journal_title

BMC gastroenterology

authors

Zhu F,Loh M,Hill J,Lee S,Koh KX,Lai KW,Salto-Tellez M,Iacopetta B,Yeoh KG,Soong R,Singapore Gastric Cancer Consortium.

doi

10.1186/1471-230X-9-76

subject

Has Abstract

pub_date

2009-10-13 00:00:00

pages

76

issn

1471-230X

pii

1471-230X-9-76

journal_volume

9

pub_type

杂志文章
  • IFI16 is involved in HBV-associated acute-on-chronic liver failure inflammation.

    abstract:BACKGROUND:Hepatitis B virus (HBV) is a hepatotropic DNA virus, and its DNA may be a potent inflammatory molecule. Interferon-inducible protein 16 (IFI16), a newly discovered DNA sensor, plays an important role in the process of inflammation in viral infections. Our study sought to identify a correlation between IFI16 ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0791-1

    authors: Pang X,Li X,Mo Z,Huang J,Deng H,Lei Z,Zheng X,Feng Z,Xie D,Gao Z

    更新日期:2018-05-09 00:00:00

  • Liver regeneration: immunohistochemical study of intrinsic hepatic innervation after partial hepatectomy in rats.

    abstract:BACKGROUND:We examined the intrinsic hepatic innervation after partial hepatectomy (PH) in rats and the presence and pattern of neural sprouting in regenerating liver. METHODS:Male Wistar rats (age 9-13 weeks-w, weight 204-356 g), were submitted to two-thirds PH. Rats were sacrificed at postoperative days (d) 1, 3, 5,...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-014-0202-1

    authors: Kandilis AN,Koskinas J,Vlachos I,Skaltsas S,Karandrea D,Karakitsos P,Pantopoulou A,Palaiologou M,Nikiteas N,Tiniakos DG,Perrea DN

    更新日期:2014-11-25 00:00:00

  • Goat milk with and without increased concentrations of lysozyme improves repair of intestinal cell damage induced by enteroaggregative Escherichia coli.

    abstract:BACKGROUND:Enteroaggregative Escherichia coli (EAEC) causes diarrhea, malnutrition and poor growth in children. Human breast milk decreases disease-causing bacteria by supplying nutrients and antimicrobial factors such as lysozyme. Goat milk with and without human lysozyme (HLZ) may improve the repair of intestinal bar...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-106

    authors: Carvalho EB,Maga EA,Quetz JS,Lima IF,Magalhães HY,Rodrigues FA,Silva AV,Prata MM,Cavalcante PA,Havt A,Bertolini M,Bertolini LR,Lima AA

    更新日期:2012-08-11 00:00:00

  • Pancreatic duct guidewire placement for biliary cannulation as a risk factor for stone residue after endoscopic transpapillary stone removal.

    abstract:BACKGROUND:Recent improvements in stone extraction implements and apparatus have lessened the complexity of the endoscopic bile duct stone treatment. However, despite confirmation of complete removal, cases of residual stones have been reported, which can result in recurrent biliary symptoms, cholangitis, and pancreati...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01428-3

    authors: Fujita A,Nakahara K,Michikawa Y,Morita R,Suetani K,Sato J,Igarashi Y,Araki R,Ikeda H,Matsunaga K,Watanabe T,Itoh F

    更新日期:2020-08-24 00:00:00

  • Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.

    abstract:BACKGROUND:FibroTest (FT) is a validated biomarker of fibrosis. To assess the applicability rate and to reduce the risk of false positives/negatives (RFPN), security algorithms were developed. The aims were to estimate the prevalence of RFPN and of proven failures, and to identify factors associated with their occurren...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-39

    authors: Poynard T,Munteanu M,Deckmyn O,Ngo Y,Drane F,Messous D,Castille JM,Housset C,Ratziu V,Imbert-Bismut F

    更新日期:2011-04-14 00:00:00

  • Access to primary care is associated with better autoimmune hepatitis outcomes in an urban county hospital.

    abstract:BACKGROUND:Autoimmune hepatitis causes chronic hepatitis and often leads to cirrhosis and death without treatment. We wanted to see if having access to primary care or insurance prior to diagnosis is associated with better outcomes for patients in an urban, public hospital with mostly socioeconomically disadvantaged Hi...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-015-0318-y

    authors: Kim D,Eshtiaghpour D,Alpern J,Datta A,Eysselein VE,Yee HF

    更新日期:2015-07-28 00:00:00

  • Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation.

    abstract:BACKGROUND:Allergic proctocolitis (APC) in exclusively breast-fed infants is caused by food proteins, deriving from maternal diet, transferred through lactation. In most cases a maternal cow milk-free diet leads to a prompt resolution of rectal bleeding, while in some patients a multiple food allergy can occur. The aim...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-82

    authors: Lucarelli S,Di Nardo G,Lastrucci G,D'Alfonso Y,Marcheggiano A,Federici T,Frediani S,Frediani T,Cucchiara S

    更新日期:2011-07-16 00:00:00

  • Inter-observer agreement in the assessment of endoscopic findings in ulcerative colitis.

    abstract:BACKGROUND:Endoscopic findings are essential in evaluating the disease activity in ulcerative colitis. The aim of this study was to evaluate how endoscopists assess individual endoscopic features of mucosal inflammation in ulcerative colitis, the inter-observer agreement, and the importance of the observers' experience...

    journal_title:BMC gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-230X-4-9

    authors: de Lange T,Larsen S,Aabakken L

    更新日期:2004-05-18 00:00:00

  • Association between NAFLD and risk of prevalent chronic kidney disease: why there is a difference between east and west?

    abstract:BACKGROUNDS:There is a discrepancy between west and east on the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). This study aimed to find out the possible reason for this and to clarify the association between NAFLD and CKD by analyzing two population-based datasets from ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01278-z

    authors: Zhang M,Lin S,Wang MF,Huang JF,Liu SY,Wu SM,Zhang HY,Wu ZM,Liu WY,Zhang DC,Hao CM,Zhu YY,Zheng MH,Wang XZ

    更新日期:2020-05-06 00:00:00

  • A simple dummy liver assist device prolongs anhepatic survival in a porcine model of total hepatectomy by slight hypothermia.

    abstract:BACKGROUND:Advances in intensive care support such as therapeutic hypothermia or new liver assist devices have been the mainstay of treatment attempting to bridge the gap from acute liver failure to liver transplantation, but the efficacy of the available devices in reducing mortality has been questioned. To address th...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-79

    authors: Thiel K,Schenk M,Etspüler A,Schenk T,Morgalla MH,Königsrainer A,Thiel C

    更新日期:2011-07-14 00:00:00

  • A survey of abnormalities in the colon and rectum in patients with haemorrhoids.

    abstract:BACKGROUND:Haemorrhoids are a common problem in daily practice. However, symptoms may also be caused by other abnormalities in the rectum or colon. Data on the presence of these abnormalities in patients with haemorrhoids is sparse. To examine the prevalence of abnormalities of the colon or rectum in patients with and ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-74

    authors: Koning MV,Loffeld RJ

    更新日期:2010-07-07 00:00:00

  • Endoscopic ultrasound criteria to predict the need for intervention in pancreatic necrosis.

    abstract:BACKGROUND:The natural course and treatment strategies for asymptomatic or oligosymptomatic pancreatic necrosis are still poorly defined. The aim of this retrospective study was to establish criteria for the need of intervention in patients with pancreatic necrosis. METHODS:A total of 31 consecutive patients (18 male,...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-48

    authors: Jürgensen C,Arlt A,Neser F,Fritscher-Ravens A,Stölzel U,Hampe J

    更新日期:2012-05-14 00:00:00

  • High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity.

    abstract:BACKGROUND:Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Necrotic tissue releases high mobility group B1 (HMGB1), and HMGB1 contributes to liver injury. Even though blockade of HMGB1 does not protect against APAP-induced acute liver injury (ALI) at 9 h time point, the later time points are not stud...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-45

    authors: Yang R,Zhang S,Cotoia A,Oksala N,Zhu S,Tenhunen J

    更新日期:2012-05-08 00:00:00

  • Acetic acid-indigo carmine chromoendoscopy for delineating early gastric cancers: its usefulness according to histological type.

    abstract:BACKGROUND:Endoscopic treatments, such as endoscopic submucosal dissection (ESD) and laparoscopic gastrectomy, are increasingly used to treat a subset of patients with early gastric cancer (EGC). To achieve successful outcomes, it is very important to accurately determine the lateral extent of the tumor. Therefore, we ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-97

    authors: Lee BE,Kim GH,Park DY,Kim DH,Jeon TY,Park SB,You HS,Ryu DY,Kim DU,Song GA

    更新日期:2010-08-23 00:00:00

  • The level and prevalence of depression and anxiety among patients with different subtypes of irritable bowel syndrome: a network meta-analysis.

    abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a very common functional bowel disorder. However, the difference of depression and anxiety comorbidities among different IBS subtypes is still not well evaluated. This study aims to investigate the difference in the level and prevalence of depression and anxiety among health...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01593-5

    authors: Hu Z,Li M,Yao L,Wang Y,Wang E,Yuan J,Wang F,Yang K,Bian Z,Zhong LLD

    更新日期:2021-01-07 00:00:00

  • HCV genotype 1a shows a better virological response to antiviral therapy than HCV genotype 1b.

    abstract:BACKGROUND:The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively investigated. The aim of this study is to determine whether the HCV genotype 1 subtypes 1a and 1b respon...

    journal_title:BMC gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-230X-12-162

    authors: Pellicelli AM,Romano M,Stroffolini T,Mazzoni E,Mecenate F,Monarca R,Picardi A,Bonaventura ME,Mastropietro C,Vignally P,Andreoli A,Marignani M,D'Ambrosio C,Miglioresi L,Nosotti L,Mitidieri O,Gentilucci UV,Puoti C,Barba

    更新日期:2012-11-16 00:00:00

  • Influence of cirrhosis on long-term prognosis after surgery in patients with combined hepatocellular-cholangiocarcinoma.

    abstract:BACKGROUND:Little is known about the prognostic impact of cirrhosis on long-term survival of patients with combined hepatocellular-cholangiocarcinoma (cHCC-CC) after hepatic resection. The aim of this study was to elucidate the long-term outcome of hepatectomy in cHCC-CC patients with cirrhosis. METHODS:A total of 144...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-017-0584-y

    authors: Zhou YM,Sui CJ,Zhang XF,Li B,Yang JM

    更新日期:2017-02-10 00:00:00

  • Low bone mass in microscopic colitis.

    abstract:BACKGROUND:Microscopic colitis presents with similar symptoms to classic inflammatory bowel diseases. Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis. AIMS:The aim of the present study was to evaluate bone density and metabolism in patien...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-58

    authors: Lorinczy K,Lakatos G,Müllner K,Hritz I,Lakatos PL,Tulassay Z,Miheller P

    更新日期:2011-05-19 00:00:00

  • Are proton pump inhibitors the first choice for acute treatment of gastric ulcers? A meta analysis of randomized clinical trials.

    abstract:BACKGROUND:Gastric ulcers are a frequent problem in the United States. Proton pump inhibitors have been shown to increase healing rates and improve clinical symptoms. The objective of this study is to compare gastric ulcer healing rates for patients treated with a proton pump inhibitor (PPI) (omeprazole, rabeprazole, p...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.1186/1471-230x-2-17

    authors: Salas M,Ward A,Caro J

    更新日期:2002-07-15 00:00:00

  • Slug down-regulation by RNA interference inhibits invasion growth in human esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive potential of ESCC cells in vitro and in vivo in immunodeficient mice. METHODS:We utilized RNA interference to knockdown Slug gene expr...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-60

    authors: Tang P,Yu Z,Zhang K,Wang Y,Ma Z,Zhang S,Chen D,Zhou Y

    更新日期:2011-05-20 00:00:00

  • 25(OH) D3 alleviate liver NK cytotoxicity in acute but not in chronic fibrosis model of BALB/c mice due to modulations in vitamin D receptor.

    abstract:BACKGROUND:Low 25-Hydroxy-vitamin-D; "25(OH)-D3" serum and vitamin D receptor (VDR) levels were recently correlated to advanced fibrosis. However, VDR mechanism in liver fibrosis modulations is not well understood. In this study, we aimed to evaluate changes in liver NK cells cytotoxicity due to modulations in VDR in C...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01248-5

    authors: Salhab A,Amer J,Yinying L,Safadi R

    更新日期:2020-04-10 00:00:00

  • Absence of Helicobacter pylori high tetracycline resistant 16S rDNA AGA926-928TTC genotype in gastric biopsy specimens from dyspeptic patients of a city in the interior of São Paulo, Brazil.

    abstract:BACKGROUND:Treatment effectiveness of Helicobacter pylori varies regionally and is decreasing worldwide, principally as a result of antibiotic resistant bacterium. Tetracycline is generally included in second line H. pylori eradication regimens. In Brazil, a high level of tetracycline resistance (TetR) is mainly associ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-49

    authors: Suzuki RB,Almeida CM,Sperança MA

    更新日期:2012-05-17 00:00:00

  • Histological improvement in chronic hepatitis B patients treated with bicyclol: real world experience.

    abstract:BACKGROUND:Bicyclol, the most commonly-used liver hepatoprotective drug in China, is often selected to control disease progression in CHB patients who refuse anti-viral treatment. However, data on histological changes after bicyclol treatment in these patients are scarce. Therefore, this study has been conducted to fin...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-1005-1

    authors: Chi X,Xiao H,Shi M,Cai G,Xie Y,Jiang J,Tian G,Wu S,Zhang C,Zhao P,Chen J

    更新日期:2019-06-13 00:00:00

  • Real-world clinical effectiveness and safety of vedolizumab and anti-tumor necrosis factor alpha treatment in ulcerative colitis and Crohn's disease patients: a German retrospective chart review.

    abstract:BACKGROUND:Real-world comparisons of biologic treatment outcomes for ulcerative colitis (UC) or Crohn's disease (CD) patients are limited. We sought to evaluate the real-world effectiveness of vedolizumab (VDZ) and anti-tumor necrosis factor alpha (anti-TNFα) in UC and CD patients in Germany. METHODS:A retrospective c...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01332-w

    authors: Helwig U,Mross M,Schubert S,Hartmann H,Brandes A,Stein D,Kempf C,Knop J,Campbell-Hill S,Ehehalt R

    更新日期:2020-07-08 00:00:00

  • Lack of evidence of viral reactivation in HBsAg-negative HBcAb-positive and HCV patients undergoing immunosuppressive therapy for psoriasis.

    abstract:BACKGROUND:HBV and HCV reactivation have been widely reported in patients undergoing immunosuppressive therapy (IT); however, few data are available on the risk of reactivation in patients with psoriasis receiving IT. The aim of our study was to assess the prevalence of HBV and HCV infection in patients with psoriasis ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-014-0214-x

    authors: Morisco F,Guarino M,La Bella S,Di Costanzo L,Caporaso N,Ayala F,Balato N

    更新日期:2014-12-19 00:00:00

  • Do gastrointestinal and respiratory signs and symptoms correlate with the severity of gastroesophageal reflux?

    abstract:BACKGROUND:Gastroesophageal reflux (GER) is a disorder that is common by seen in childhood and may lead to severe complications. In this study, we ascertained the incidence of GER among the children who had typical and atypical complaints of GER and whether there was a difference between two groups comparing the findin...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-22

    authors: Uzun H,Alagoz D,Okur M,Dikici B,Kocabay K,Senses DA,Ozkan A,Kaya M

    更新日期:2012-03-21 00:00:00

  • Unsedated peroral wireless pH capsule placement vs. standard pH testing: a randomized study and cost analysis.

    abstract:BACKGROUND:Wireless capsule pH-metry (WC) is better tolerated than standard nasal pH catheter (SC), but endoscopic placement is expensive. AIMS:to confirm that non-endoscopic peroral manometric placement of WC is as effective and better tolerated than SC and to perform a cost analysis of the available esophageal pH-me...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-230X-12-58

    authors: Andrews CN,Sadowski DC,Lazarescu A,Williams C,Neshev E,Storr M,Au F,Heitman SJ

    更新日期:2012-05-31 00:00:00

  • "Fast track" rehabilitation after gastric cancer resection: experience with 80 consecutive cases.

    abstract:BACKGROUND:To evaluate the safety, efficacy and outcomes of fast-track rehabilitation applied to gastric cancer proximal, distal and total gastrectomy. METHODS:Eighty consecutive patients undergoing gastric cancer resection performed by a single surgeon, received perioperative multimodal rehabilitation. Demographic an...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-147

    authors: Song JX,Tu XH,Wang B,Lin C,Zhang ZZ,Lin LY,Wang L

    更新日期:2014-08-18 00:00:00

  • Adequacy and quality of abdominal echographies requested by primary care professionals.

    abstract:BACKGROUND:The value of abdominal echography in primary care is great because it is innocuous, inexpensive, easy to perform and provides a great deal of information making this the first examination to be requested in cases of probable abdominal disease. However, too many abdominal echographies are probably requested o...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-230X-10-101

    authors: Auladell MA,Caballeria L,Pera G,Rodríguez L,Casas JD,Aznar J,Miranda D,Sánchez C,Negrete A,Castellví JM,Bernad J,Canut S,Aubà J,Aizpurua MM,Torán P

    更新日期:2010-09-06 00:00:00

  • Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND:Peritumoral ductular reaction (DR) was reported to be related to the prognosis of combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma. Non-mucin-producing intrahepatic cholangiocarcinoma (ICC) which may be derived from small bile duct cells or liver progenitor cells (LPCs) was known to us...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01471-0

    authors: Shen Z,Xiao J,Wang J,Lu L,Wan X,Cai X

    更新日期:2020-10-02 00:00:00