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Bone mineral density in hip-fracture patients with Parkinson's disease: a case-control study.

Abstract：

OBJECTIVE:To investigate bone mineral density (BMD) levels in patients with Parkinson's disease (PD) who sustained a hip fracture. DESIGN:Case-control study. SETTING:Rehabilitation hospital in Italy. PARTICIPANTS:We investigated 831 out of 887 white patients consecutively admitted to a rehabilitation hospital because of an original hip fracture resulting from a fall. Twenty-eight (3.37%) of the 831 patients were affected by PD. Twenty-eight controls matched for sex, age, and hip-fracture type (cervical or trochanteric) were found among the 803 non-PD patients. INTERVENTIONS:Not applicable. MAIN OUTCOME MEASURES:BMD was assessed by dual-energy x-ray absorptiometry (DXA) at the unfractured femur. Five sites were investigated in each subject: total proximal femur, femoral neck, trochanter, intertrochanteric area, and Ward's triangle. DXA scan was performed a mean +/- standard deviation of 22.2 +/- 7.8 days after fracture occurrence in the 28 patients and 22.0 +/- 5.3 days after fracture occurrence in the 28 controls. RESULTS:BMD expressed as a T score did not differ significantly between the 28 PD patients and the 28 controls, whereas z score in the PD patients was significantly lower than 0 +/- 1 in the age- and sex-matched general population at 4 of the 5 sites of BMD assessment. CONCLUSIONS:A sample of PD fallers who sustained a hip fracture had femoral BMD levels similar to those found in matched hip-fracture fallers who did not suffer from PD and significantly lower than those found in the matched reference population.

journal_name

Arch Phys Med Rehabil

journal_title

Archives of physical medicine and rehabilitation

authors

Di Monaco M,Vallero F,Di Monaco R,Tappero R,Cavanna A

doi

10.1016/j.apmr.2006.07.265

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

1459-62

issue

11

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(06)00870-7

journal_volume

87

pub_type

杂志文章

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