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Effect of dehydroepiandrosterone (DHEA) treatment on oxidative energy metabolism in rat liver and brain mitochondria. A dose-response study.

Abstract：

OBJECTIVES:Effects of treatment with dehydroepiandrosterone (DHEA) on oxidative energy metabolism in rat liver and brain mitochondria were examined. DESIGN AND METHODS:Young adult rats were administered DHEA (0.1, 0.2, 1.0 or 2.0 mg/kg body weight) by subcutaneous route for 7 consecutive days. RESULTS:DHEA treatment resulted in general, in stimulation of state 3 respiration rates without having any uncoupling effect on ADP/O ratios. The stimulation of state 3 respiration rate for a given substrate was dose dependent in a tissue-specific manner. Parallel increases in the contents of cytochromes aa(3) and b were also noted. DHEA treatment stimulated the glutamate dehydrogenase (GDH) and succinate DCIP reductase (SDR) activities. Under the treatment conditions, mitochondrial ATPase activity was also stimulated. CONCLUSIONS:Treatment with DHEA significantly stimulated oxidative energy metabolism in liver and brain mitochondria.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Patel MA,Katyare SS

doi

10.1016/j.clinbiochem.2006.08.014

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

57-65

issue

1-2

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(06)00281-5

journal_volume

40

pub_type

杂志文章

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