Treatment of cervical intraepithelial neoplasia levels 2 and 3 with adapalene, a retinoid-related molecule.

Abstract:

OBJECTIVES:This study examined dose scheduling, safety, and efficacy of adapalene in the treatment of CIN2 and CIN3. METHODS:Patients were instructed on insertion and removal of an adapalene delivery system. Treatment regimens of 4, 8, and 14 days were utilized. Biopsies were performed on day 90 to assess efficacy. Safety was evaluated with toxicity questionnaires and patient interviews. RESULTS:Two patients treated for 4 days had stable disease. Twenty-three patients treated for 8 days demonstrated an overall 61% (14 of 23) response rate. Twenty-four patients treated for 14 days had an overall 38% (9 of 24) response rate. No patient had disease progression. Compared to untreated historical controls, significantly improved efficacy was demonstrated for patients with CIN2. Patients with CIN3 had improved efficacy, though not statistically significant. CONCLUSIONS:The lack of side effects and practicality of home use make adapalene a nontoxic and safe alternative to surgical therapy in patients with CIN2 and CIN3.

journal_name

J Low Genit Tract Dis

authors

DiSilvestro PA,DiSilvestro JM,Lernhardt W,Pfahl M,Mannel RS

doi

10.1046/j.1526-0976.2001.51007.x

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

33-7

issue

1

eissn

1089-2591

issn

1526-0976

pii

00128360-200101000-00007

journal_volume

5

pub_type

杂志文章
  • Giant condyloma versus verrucous carcinoma: a case report.

    abstract::Giant condyloma acuminatum is a large, slow-growing, exophytic, cauliflower-like tumor of the external genitalia. It is a histologically benign lesion, largely associated with human papillomavirus infection but with a high recurrence rate. The main differential diagnosis includes verrucous carcinoma. Differentiation b...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3181c945ed

    authors: Bambao C,Nofech-Mozes S,Shier M

    更新日期:2010-07-01 00:00:00

  • Comparison of Tissue Yield Using Frictional Fabric Brush Versus Sharp Curettage For Endocervical Curettage.

    abstract:OBJECTIVE:The aim of the study was to evaluate and compare the diagnostic yield of conventional endocervical curettage (ECC) with fabric-based ECC in a consistent physician group. MATERIALS AND METHODS:This is a retrospective case-control study of patients who underwent ECC both before and after introduction of a fabr...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000324

    authors: Diedrich JT,Rathore S,Bentz JS

    更新日期:2017-10-01 00:00:00

  • Efficacy of treatment of inflammatory cytologic abnormalities detected by papanicolaou smears: a pilot study.

    abstract:OBJECTIVE:To evaluate the efficacy of metronidazole versus no treatment for the empiric treatment of inflammatory cytologic changes. MATERIALS AND METHODS:Patients with inflammatory changes on Pap smear were serially assigned to receive no treatment or metronidazole by one of three regimens: 2 grams orally as a single...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1046/j.1526-0976.2001.005002082.x

    authors: Webb JC,Wharton GG,Hawley-Bowland C,Carlson JW

    更新日期:2001-04-01 00:00:00

  • Vulvovaginal candidiasis in postmenopausal women: the role of hormone replacement therapy.

    abstract:OBJECTIVE:: This study aimed to explore the role of hormone replacement therapy (HRT) in susceptibility to vulvovaginal candidiasis (VVC) in a private vulval disease referral practice. METHODS:: Between January 2009 and December 2010, 149 healthy, nondiabetic patients with vulvar conditions were compared for significa...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3182241f1a

    authors: Fischer G,Bradford J

    更新日期:2011-10-01 00:00:00

  • Electrofulguration for low-grade squamous intraepithelial lesions of the cervix (CIN 1).

    abstract:OBJECTIVES:To evaluate the therapeutic efficacy and adverse events of electrofulguration for the treatment of cervical intraepithelial lesion grade 1 (CIN 1). MATERIALS AND METHODS:Women aged 19 years and older received electrofulguration for histologically proven exocervical CIN 1. They were followed up at 3, 6, and ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-200401000-00004

    authors: Roy MC,Mayrand MH,Franco E,Arseneau J,Ferenczy A

    更新日期:2004-01-01 00:00:00

  • Fact or Fiction? Adipose-Derived Stem Cells and Platelet-Rich Plasma for the Treatment of Vulvar Lichen Sclerosus.

    abstract:OBJECTIVE:The aim of the study was to summarize and review the evidence for the efficacy and safety of adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus (LS). MATERIALS AND METHODS:PubMed/MEDLINE, Ovid, Web of Science, and clinicaltrials.gov were searched fr...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审

    doi:10.1097/LGT.0000000000000440

    authors: Eshtiaghi P,Sadownik LA

    更新日期:2019-01-01 00:00:00

  • Clinical significance of cervical smears with atypical squamous cells of undetermined significance designated "favor reactive" or "favor preneoplastic".

    abstract:OBJECTIVE:Our aim was to determine the clinical significance of the two subgroups of atypical squamous cells of undetermined significance (ASCUS), designated "favor reactive" and "favor preneoplastic." MATERIALS AND METHODS:Cervical Papanicolaou smears with a diagnosis of ASCUS favor reactive or ASCUS favor preneoplas...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-199707000-00006

    authors: Yang M,Zachariah S

    更新日期:1997-07-01 00:00:00

  • Use of Smartphones as Adjuvant Tools for Cervical Cancer Screening in Low-Resource Settings.

    abstract:OBJECTIVES:Our aim was to evaluate the feasibility and performance of smartphone digital images for the detection of cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) as an adjunct to a conventional visual inspection approach with acetic acid (VIA) and Lugol's iodine (VILI), in comparison with detection by...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000136

    authors: Ricard-Gauthier D,Wisniak A,Catarino R,van Rossum AF,Meyer-Hamme U,Negulescu R,Scaringella S,Jinoro J,Vassilakos P,Petignat P

    更新日期:2015-10-01 00:00:00

  • The association of p16(INK4A) and fragile histidine triad gene expression and cervical lesions.

    abstract:OBJECTIVE:This cross-sectional study was intended to assess the association between immunohistochemical analysis of p16 and fragile histidine triad (FHIT) and the presence of precancerous cervical lesions. MATERIALS AND METHODS:Women seen at Pérola Byington Hospital, São Paulo, Brazil, with histologically confirmed ce...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31802efb9e

    authors: Longatto-Filho A,Etlinger D,Pereira SM,Kanamura CT,di Loreto C,Santos Gda C,Makabe S,Marques JA,Santoro CL,das Dores GB,Castelo A

    更新日期:2007-07-01 00:00:00

  • Hair in the vagina: a case series.

    abstract:BACKGROUND:: Lack of estrogen after menopause can cause many changes in the lower genital tract of women, including involution of the introitus and collapse of the vestibule into the genital cleft. CASES:: Six cases of hypoestrogenic women are described, with the unusual finding of entrapment of terminal hairs between...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31821a68a5

    authors: Vigliani MB

    更新日期:2011-10-01 00:00:00

  • Detection of bacterial vaginosis, Trichomonas vaginalis infection, and vaginal Candida infection: a comparative study of methods of extracting exudates, with and without a speculum, during pregnancy.

    abstract:PURPOSE:To compare the collection of vaginal exudates with and without the use of a speculum to diagnose vaginal infections. MATERIAL AND METHODS:We examined 45 patients with vaginal discharge. Two vaginal swabs were taken, one with and the other without a speculum. Both were examined by wet mount microscopy to detect...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/01.lgt.0000179859.29456.ba

    authors: Audisio T,Penacino M,Cannistraci R,Bertolotto P

    更新日期:2005-10-01 00:00:00

  • Use of electronic medical record-based tools to improve compliance with cervical cancer screening guidelines: effect of an educational intervention on physicians' practice patterns.

    abstract:OBJECTIVE:This study aimed to determine whether electronic medical record (EMR)-based tools influence providers' compliance with guidelines for cervical cancer screening in adolescent (<21 y) patients. MATERIALS AND METHODS:Three EMR-based tools to educate providers on cervical cancer screening guidelines were impleme...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3182607137

    authors: White P,Kenton K

    更新日期:2013-04-01 00:00:00

  • Home study course: summer 2005.

    abstract:OBJECTIVE:The Home Study Course is intended for the practicing colposcopist or practitioner who is seeking to develop or enhance his or her colposcopic skills. The goal of the course is to present colposcopic cases that are unusual or instructive in terms of appearance, presentation, or management, or that demonstrate ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/01.lgt.0000171660.77437.f2

    authors: Berry JM,Darragh TM

    更新日期:2005-07-01 00:00:00

  • Fabric-based exocervical and endocervical biopsy in comparison with punch biopsy and sharp curettage.

    abstract:OBJECTIVES:Fabric-based endocervical and exocervical biopsy tools were compared with exocervical punch biopsy and sharp endocervical curettage. We compared the level of pain reported by the patient and the amount of bleeding rated by the physician relative to the type of biopsy used. MATERIALS AND METHODS:This was a 2...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/LGT.0b013e318234262d

    authors: Winter M,Cestero RM,Burg A,Felix JC,Han C,Raffo AM,Vasilev S

    更新日期:2012-04-01 00:00:00

  • Differences in cervical cytologic and histologic findings between women using depot-medroxyprogesterone acetate and oral contraceptives.

    abstract:OBJECTIVE:This study aimed to compare cervical cytologic and histologic findings between women using depot-medroxyprogesterone acetate (DMPA) and oral contraceptives (OCs) referred for colposcopy and to determine whether there were differences in the occurrence of false-positive cytologic finding between the 2 contrace...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31820eb140

    authors: Clark MK,Stockdale CK,Railsback L,Nichols S

    更新日期:2011-07-01 00:00:00

  • Atypical polypoid adenomyoma mimicking cervical adenocarcinoma.

    abstract::Atypical polypoid adenomyoma (APA) of the uterus is a rare, benign lesion. Histologically, it is composed of a glandular and squamous cell proliferation with architectural complexity and cytologic atypia of glands, and a hypercellular smooth muscle stroma. APA is difficult to distinguish from well-differentiated adeno...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1046/j.1526-0976.2002.61007.x

    authors: Jakus S,Edmonds P,Dunton C,Holland G

    更新日期:2002-01-01 00:00:00

  • Chronic vulvar fissure--a rare manifestation of mycosis fungoides.

    abstract:BACKGROUND:Vulvar fissures are a common cause of vulvar pain and discomfort. The differential diagnosis of the underlying process is broad, and some cases remain undiagnosed. Mycosis fungoides, the dominant component of cutaneous T-cell lymphoma, rarely present as fissures. We report a case of a chronic vulvar fissure ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31819d09ad

    authors: Reichman O,Sobel JD,Bentley G

    更新日期:2010-01-01 00:00:00

  • Association of Body Mass Index With Adherence to Cervical Cancer Screening Recommendations in Hispanic Women.

    abstract:OBJECTIVE:Obese women have higher cervical cancer incidence and mortality than their counterparts, possibly related to nonadherence to screening recommendations. We assessed the association of body mass index with adherence to cervical cancer screening recommendations in Hispanic women living in Puerto Rico, a minority...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000504

    authors: Pérez CM,González-Barrios D,Ramos-Cartagena JM,Ortiz AP

    更新日期:2020-01-01 00:00:00

  • Validity of the Papanicolaou Smear in the Diagnosis of Candida spp., Trichomonas vaginalis, and Bacterial Vaginosis.

    abstract:OBJECTIVE:To determine the validity of the Papanicolaou smear in the diagnosis of bacterial vaginosis, Trichomonas vaginalis, and Candida spp. MATERIALS AND METHODS:We determined the sensitivity, specificity, positive predictive value, and negative predictive value of Pap smears we performed in 824 symptomatic patient...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:

    authors: Audisio T,Pigini T,de Riutort SV,Schindler L,Ozan M,Tocalli C,Bertolotto P

    更新日期:2001-10-01 00:00:00

  • Pregnancy-related fibroadenoma of ectopic breast tissue in the vulva.

    abstract:BACKGROUND:Pregnancy-related vulvar fibroadenoma of ectopic breast tissue is rare. Management involves diagnosing the mass as a fibroadenoma by physical examination and delaying excision until the postpartum period. CASE:A 31-year-old multigravid woman at 29 weeks' gestation had a right labial mass that was increasing...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-199707000-00035

    authors: Xanos ET,Kennedy DA,Grosen EA

    更新日期:1997-07-01 00:00:00

  • Management of "Atypical Endocervical Cells" Compared to "Atypical Glandular Cells".

    abstract:OBJECTIVE:To assess adherence to management guidelines based on the terminology used to describe atypical glandular cells (AGC) on cytology reports. MATERIALS AND METHODS:We analyzed AGC pathology reports from Hartford Hospital, 2004-2007, and identified cases of AGC with the terminology atypical glandular cells or at...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000089

    authors: Sharpless KE,Schnatz PF

    更新日期:2015-07-01 00:00:00

  • Vaginal Stenosis After Gonadotropin-Releasing Hormone Agonist Therapy During Treatment for Acute Lymphoblastic Leukemia.

    abstract::A 26-year-old patient with a history of chemotherapy for acute lymphoblastic leukemia presented with secondary amenorrhea and cyclic abdominal pain, and she was found to have vaginal stenosis due to adhesion of vaginal wall. The cause of the adhesion was considered to be vaginal inflammation induced by anticancer agen...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000175

    authors: Sato M,Harada M,Oishi H,Wada-Hiraike O,Hirata T,Nagasaka K,Koga K,Fujii T,Osuga Y

    更新日期:2016-04-01 00:00:00

  • Comparison of human papilloma virus testing and spectroscopy combined with cervical cytology for the detection of high-grade cervical neoplasia.

    abstract:OBJECTIVE:This study compared the performance of cervical cytology plus human papilloma virus testing (Pap + HPV) or cervical spectroscopy (Pap + CS) for identifying high-grade cervical neoplasia in a high-risk population of women referred for colposcopy. MATERIALS AND METHODS:Each of 113 subjects underwent spectrosco...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/01.lgt.0000230208.58118.58

    authors: Werner CL,Griffith WF 3rd,Ashfaq R,Gossett D,Wilkinson E,Raab S,Bambot S,Mongin D,Faupel M

    更新日期:2007-04-01 00:00:00

  • Home study course: Summer 2004.

    abstract:OBJECTIVE:The Home Study Course is intended for the practicing colposcopist or practitioner who is seeking to develop or enhance his or her colposcopic skills. The goal of the course is to present colposcopic cases that are unusual or instructive in terms of appearance, presentation, or management, or that demonstrate ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-200407000-00013

    authors: Dunton CJ

    更新日期:2004-07-01 00:00:00

  • A case report of disseminated tuberculosis: an unsuspected uterine cervical mass in a young native american woman with new-onset seizure disorder.

    abstract::Disseminated tuberculosis involving the uterine cervix and central nervous system is described in a 26-year-old Native American female with new-onset seizures. Her presenting complaint was generalized seizures with associated weight loss, chronic cough, global headache, and malaise. Pelvic examination revealed an exop...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1046/j.1526-0976.1999.08099.x

    authors: Kern TW,Waxman AG,Kilgo R,Tempest B

    更新日期:1999-04-01 00:00:00

  • The vaginal vestibule.

    abstract:OBJECTIVES:Vulvar vestibule is a common term in the medical nomenclature. In our view, this term is inaccurate. MATERIALS AND METHODS:Herein, we provide evidence from embryologic, anatomic, and architectonic textbooks that shows the links between the vestibule and vagina. RESULTS:Our research proves that the term vul...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-200401000-00014

    authors: Friedman M,Siegler E,Löwenstein L

    更新日期:2004-01-01 00:00:00

  • Music or guided imagery for women undergoing colposcopy: a randomized controlled study of effects on anxiety, perceived pain, and patient satisfaction.

    abstract:OBJECTIVE:It was hypothesized that music or guided imagery versus usual care would result in less anxiety and perceived pain for colposcopy patients. MATERIALS AND METHODS:Patients were randomized to music, guided imagery, or usual care after completing a baseline questionnaire. All patients completed a postprocedure ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.lgt.0000230206.50495.4c

    authors: Danhauer SC,Marler B,Rutherford CA,Lovato JF,Asbury DY,McQuellon RP,Miller BE

    更新日期:2007-01-01 00:00:00

  • History of Abuse in Women With Vulvar Pruritus, Vulvodynia, and Asymptomatic Controls.

    abstract:OBJECTIVE:Chronic vulvar pruritus and vulvodynia are common vulvar diseases. The aim of this study was to compare gynecologic and sexual and physical abuse histories from patients with these diagnoses and from healthy controls. MATERIALS AND METHODS:Questionnaires were self-completed by patients diagnosed with vulvar ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000075

    authors: Cohen-Sacher B,Haefner HK,Dalton VK,Berger MB

    更新日期:2015-07-01 00:00:00

  • Natural history of low-grade squamous intraepithelial lesion.

    abstract:OBJECTIVE:To determine guidelines for management of CIN1 by evaluating its natural history. METHODS:One hundred fifty-eight patients were diagnosed with CIN1 had colposcopy follow-up with or without cytology every three months. RESULTS:Colposcopically directed biopsy confirmed progression to CIN2 or CIN3 in 17 of 158...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:

    authors: Saw HS,Lee JK,Lee HL,Jee HJ,Hyun JJ

    更新日期:2001-07-01 00:00:00

  • Presence of Spontaneous Pain and Comorbid Pain Conditions Identifies Vulvodynia Subgroups.

    abstract:OBJECTIVE:The aims of the study were to define the heterogeneity of vulvodynia by determining data-driven subgroups within the vulvodynia diagnosis using exploratory cluster analysis and to characterize the subgroups identified. MATERIALS AND METHODS:Included were participants in the longitudinal population-based stud...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000166

    authors: Reed BD,Plegue MA,Williams DA,Sen A

    更新日期:2016-01-01 00:00:00