Is there an epidemiological link between human papillomavirus DNA and basaloid squamous cell carcinoma of the pharynx?

Abstract:

:The epidemiological link between human papillomavirus (HPV) DNA and basaloid squamous cell carcinoma (BSCC) of the pharynx was studied. The expression of p53 protein was evaluated by immunohistochemical analysis. The presence of HPV DNA was evaluated by polymerase chain reaction amplification and "in situ" hybridization. The tobacco and alcohol consumption and the clinical outcomes of nine patients with BSCC of the pharynx are compared with site and stage matched 109 conventional squamous cell carcinoma (SCC) patients. The BSCC specimens were analyzed for the presence of HPV DNA and p53 expression. We did not find any significant differences in tobacco and alcohol consumption between patients with BSCC and patients with SCC. No HPV DNA was detected in BSCC, and p53 overexpression was found in five (55%) of the cases. Our results do not support an etiological link between HPV DNA and BSCC.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

Cabanillas R,Rodrigo JP,Ferlito A,Rinaldo A,Fresno MF,Aguilar C,Alvarez ME,Suárez C

doi

10.1016/j.oraloncology.2006.04.014

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

327-32

issue

4

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(06)00126-6

journal_volume

43

pub_type

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