Abstract:
:Structure-activity relationships for a recently discovered thiazolyl phenyl ether series of acetyl-CoA carboxylase (ACC) inhibitors were investigated. Preliminary efforts to optimize the series through modification of the distal aryl ether moiety of the lead scaffold resulted in the identification of compounds exhibiting low-nanomolar potency and isozyme-selective ACC2 activity.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Clark RF,Zhang T,Xin Z,Liu G,Wang Y,Hansen TM,Wang X,Wang R,Zhang X,Frevert EU,Camp HS,Beutel BA,Sham HL,Gu YGdoi
10.1016/j.bmcl.2006.08.100subject
Has Abstractpub_date
2006-12-01 00:00:00pages
6078-81issue
23eissn
0960-894Xissn
1464-3405pii
S0960-894X(06)01013-4journal_volume
16pub_type
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