Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.

Abstract:

:Structure-activity relationships for a recently discovered thiazolyl phenyl ether series of acetyl-CoA carboxylase (ACC) inhibitors were investigated. Preliminary efforts to optimize the series through modification of the distal aryl ether moiety of the lead scaffold resulted in the identification of compounds exhibiting low-nanomolar potency and isozyme-selective ACC2 activity.

journal_name

Bioorg Med Chem Lett

authors

Clark RF,Zhang T,Xin Z,Liu G,Wang Y,Hansen TM,Wang X,Wang R,Zhang X,Frevert EU,Camp HS,Beutel BA,Sham HL,Gu YG

doi

10.1016/j.bmcl.2006.08.100

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

6078-81

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)01013-4

journal_volume

16

pub_type

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