Abstract:
:The functional promoter polymorphism -116C/G of the X-box binding protein 1 (XBP1) gene was found to be associated with schizophrenia in Han Chinese and Japanese subjects, although contradictive negative findings were also reported in European populations. To confirm this association in a Japanese population, the authors conducted a case-control association study. There was no significant difference in both genotype and allele frequencies between the patients and control subjects, suggesting that the XBP1 -116C/G polymorphism might not confer increased susceptibility for schizophrenia in a Japanese population. However, further studies using a larger sample with detailed clinical data should be performed in several populations.
journal_name
Psychiatry Clin Neuroscijournal_title
Psychiatry and clinical neurosciencesauthors
Watanabe Y,Fukui N,Muratake T,Amagane H,Kaneko N,Nunokawa A,Someya Tdoi
10.1111/j.1440-1819.2006.01570.xsubject
Has Abstractpub_date
2006-10-01 00:00:00pages
633-5issue
5eissn
1323-1316issn
1440-1819pii
PCN1570journal_volume
60pub_type
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