Association study of a functional promoter polymorphism of the X-box binding protein 1 gene in Japanese patients with schizophrenia.

Abstract:

:The functional promoter polymorphism -116C/G of the X-box binding protein 1 (XBP1) gene was found to be associated with schizophrenia in Han Chinese and Japanese subjects, although contradictive negative findings were also reported in European populations. To confirm this association in a Japanese population, the authors conducted a case-control association study. There was no significant difference in both genotype and allele frequencies between the patients and control subjects, suggesting that the XBP1 -116C/G polymorphism might not confer increased susceptibility for schizophrenia in a Japanese population. However, further studies using a larger sample with detailed clinical data should be performed in several populations.

authors

Watanabe Y,Fukui N,Muratake T,Amagane H,Kaneko N,Nunokawa A,Someya T

doi

10.1111/j.1440-1819.2006.01570.x

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

633-5

issue

5

eissn

1323-1316

issn

1440-1819

pii

PCN1570

journal_volume

60

pub_type

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