Effect of erroneous surgical procedures on recurrence and survival rates for patients with osteosarcoma.

Abstract:

:To determine whether inappropriate surgical procedures based on an initial misdiagnosis affected recurrence and survival rates, we retrospectively reviewed the surgical treatment and results of 117 patients with high-grade osteosarcomas treated from January 1, 1990 to December 31, 2000. Nine patients had intralesional curettage performed at other institutions based on an erroneous diagnosis of a benign lesion. Two of the nine patients had amputations and seven patients had limb-salvage procedures. Of the 108 patients who were not misdiagnosed, six patients had amputations and 102 patients had limb-salvage procedures. All patients received neoadjuvant therapy. Fifteen of the 117 patients had local recurrences. Patients who had erroneous surgical procedures based on the initial misdiagnosis of osteosarcoma had an increased risk of local recurrence and decreased 10-year survival rate. Response to adjuvant therapy and the amount of previous violation of natural tumor barriers should be evaluated carefully before deciding surgical treatment.

journal_name

Clin Orthop Relat Res

authors

Ayerza MA,Muscolo DL,Aponte-Tinao LA,Farfalli G

doi

10.1097/01.blo.0000229314.58878.88

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

231-5

eissn

0009-921X

issn

1528-1132

journal_volume

452

pub_type

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