Abstract:
:Aggressive angiomyxoma (AA), first described by Steeper and Rosai (Am J SurgPathol. 1983;7:463-475), is a rare locally infiltrative tumor that usually arises in the pelvic and perineal soft tissues of young women. Approximately 150 cases have been reported in women. Aggressive angiomyxoma has a high rate of local recurrence because of its infiltrative growth and anatomical location making complete excision with wide margins difficult. To our knowledge, 39 cases of AA occurring in men have been reported in the literature. Sites frequently involved include the scrotum, spermatic cord, inguinal region, and perineum. The gross and microscopic appearances and clinical course are similar to those described in female cases. Immunohistochemistry evaluating estrogen and progesterone receptors (ER and PR, respectively), although frequently positive in the female cases, has rarely been studied in the male cases. We report the clinicopathologic features of 4 additional cases of AA in men with particular emphasis on hormone (ER/PR) receptor status. Hormone reactivity is significant in that AA may arise from specialized hormonally responsive stromal cells of the perineum and may potentially play a therapeutic role in unresectable tumors. From our small series, hormone positivity (1 case of ER+, 3 cases of PR+) does occur in the male cases of AA, and a large number of cases should be examined to determine the frequency at which these tumors express hormone receptors.
journal_name
Ann Diagn Patholjournal_title
Annals of diagnostic pathologyauthors
Idrees MT,Hoch BL,Wang BY,Unger PDdoi
10.1016/j.anndiagpath.2005.09.002subject
Has Abstractpub_date
2006-08-01 00:00:00pages
197-204issue
4eissn
1092-9134issn
1532-8198pii
S1092-9134(05)00155-3journal_volume
10pub_type
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journal_title:Annals of diagnostic pathology
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journal_title:Annals of diagnostic pathology
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journal_title:Annals of diagnostic pathology
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/j.anndiagpath.2006.02.003
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2004.12.010
更新日期:2005-04-01 00:00:00
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journal_title:Annals of diagnostic pathology
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journal_title:Annals of diagnostic pathology
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2007.10.001
更新日期:2008-08-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2020.151593
更新日期:2020-10-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/j.anndiagpath.2017.11.003
更新日期:2018-04-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1053/adpa.2001.23019
更新日期:2001-04-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/j.anndiagpath.2009.09.002
更新日期:2009-12-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/j.anndiagpath.2011.10.001
更新日期:2012-06-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1053/j.anndiagpath.2004.04.009
更新日期:2004-08-01 00:00:00
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journal_title:Annals of diagnostic pathology
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doi:10.1016/j.anndiagpath.2019.05.006
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journal_title:Annals of diagnostic pathology
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journal_title:Annals of diagnostic pathology
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journal_title:Annals of diagnostic pathology
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2010.07.012
更新日期:2011-04-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2014.08.007
更新日期:2014-12-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/s1092-9134(99)80056-2
更新日期:1999-08-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2004.03.005
更新日期:2004-06-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2009.05.006
更新日期:2009-12-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/j.anndiagpath.2017.05.002
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Hodgkin's Lymphoma (HL) is a peculiar subtype of lymphoid malignancies. The etiology of HL is still unknown. Insulin-like growth factor II mRNA-binding Protein 3 (IMP3) is a member of IMP family. In HL, IMP3 is expressed in the cytoplasmic compartment of the tumor cells (in both HRS cells & LP cells) against...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2019.06.006
更新日期:2019-10-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2009.08.005
更新日期:2010-10-01 00:00:00