Abstract:
:Although a dose-effect relationship between water fluoride levels and damage to liver and kidney functions in animals has been reported, it was not demonstrated in humans. To evaluate the effects of drinking water fluoride levels on the liver and kidney functions in children with and without dental fluorosis, we identified 210 children who were divided into seven groups with 30 each based on different drinking water fluoride levels in the same residential area. We found that the fluoride levels in serum and urine of these children increased as the levels of drinking water fluoride increased. There were no significant differences in the levels of total protein (TP), albumin (ALB), aspartate transamine (AST), and alanine transamine (ALT) in serum among these groups. However, the activities of serum lactic dehydrogenase (LDH), urine N-acetyl-beta-glucosaminidase (NAG), and urine gamma-glutamyl transpeptidase (gamma-GT) in children with dental fluorosis and having water fluoride of 2.15-2.96 mg/L and in children having water fluoride of 3.15-5.69 mg/L regardless of dental fluorosis were significantly higher than children exposed to water fluoride of 0.61-0.87 mg/L in a dose-response manner. In contrast to children with dental fluorosis and having water fluoride of 2.15-2.96 and 3.10-5.69 mg/L, serum LDH activity of children without dental fluorosis but exposed to the same levels of water fluoride as those with dental fluorosis were also markedly lower, but the activities of NAG and gamma-GT in their urine were not. Therefore, our results suggest that drinking water fluoride levels over 2.0mg/L can cause damage to liver and kidney functions in children and that the dental fluorosis was independent of damage to the liver but not the kidney. Further studies on the mechanisms and significance underlying damage to the liver without dental fluorosis in the exposed children are warranted.
journal_name
Environ Resjournal_title
Environmental researchauthors
Xiong X,Liu J,He W,Xia T,He P,Chen X,Yang K,Wang Adoi
10.1016/j.envres.2006.05.008subject
Has Abstractpub_date
2007-01-01 00:00:00pages
112-6issue
1eissn
0013-9351issn
1096-0953pii
S0013-9351(06)00126-5journal_volume
103pub_type
杂志文章abstract:BACKGROUND AND AIM:We reexamine whether radio frequency radiation (RFR) in the occupational and military settings is a human carcinogen. METHODS:We extended an analysis of an already-reported case series of patients with cancer previously exposed to whole-body prolonged RFR, mainly from communication equipment and rad...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.01.003
更新日期:2018-05-01 00:00:00
abstract::On May 24-25, 2005 in Ann Arbor, Michigan, the US Environmental Protection Agency, the National Institute of Environmental Health Sciences, and the University of Michigan sponsored a technical workshop on the topic of connecting social and environmental factors to measure and track environmental health disparities. Th...
journal_title:Environmental research
pub_type:
doi:10.1016/j.envres.2005.11.001
更新日期:2006-10-01 00:00:00
abstract::Studies of heat-related mortality have been predominantly based on analyses of underlying cause of death as the single indicator of a population's vulnerability to high temperatures. Examination of both underlying and associated causes of death could provide a more comprehensive understanding of the population at risk...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2008.07.015
更新日期:2008-11-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章,meta分析
doi:10.1016/j.envres.2020.109970
更新日期:2020-11-01 00:00:00
abstract::This paper examines the reliability of sport fish consumption data from the New York State Angler Cohort Study (NYSACS). NYSACS is a prospective cohort study conducted among New York State registered sportsmen and fishermen. Sport fish consumption information for New York State waters including the Great Lakes between...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2004.01.010
更新日期:2005-02-01 00:00:00
abstract::Samples from 75 paint products made by 21 domestic and foreign manufacturers were purchased from retail stores in five major cities in Nepal and tested for lead content. Information provided on product labels were noted. Samples were selected to be representative of the large number of brands and colors available in r...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.03.036
更新日期:2014-07-01 00:00:00
abstract::The effect of oxygen exposure on nitrosylhemoglobin of whole human blood or its buffered solution has been determined. The amount of methemoglobin formed was determined by an anaerobic modification of the Evelyn-Malloy method; 59% of the total hemoglobin of whole blood was oxidized to methemoglobin in the first 15 min...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(85)90116-1
更新日期:1985-08-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.2000.4089
更新日期:2000-11-01 00:00:00
abstract::The practice of social distancing and wearing masks has been popular worldwide in combating the contraction of COVID-19. Undeniably, although such practices help control the COVID-19 pandemic to a greater extent, the complete control of virus-laden droplet and aerosol transmission by such practices is poorly understoo...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1016/j.envres.2020.109819
更新日期:2020-09-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110316
更新日期:2021-01-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109856
更新日期:2020-10-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(89)80047-7
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:The relationship between environmental factors and allergic rhinitis (AR) has become a focal point recently. However, few studies have investigated the adverse effects of both high relative humidity (RH) and low relative humidity. Moreover, the laged effect and disease burden of RH on AR were also neglected....
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.03.040
更新日期:2019-06-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(87)80042-7
更新日期:1987-08-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.envres.2018.09.016
更新日期:2019-01-01 00:00:00
abstract::Muscles, gonads, and liver tissues of fish caught in Sepetiba and Ilha Grande Bay were analyzed to assess levels of heavy metal concentrations of Cd, Fe, Zn, Pb, Ni, Cu, and Cr. Levels of Cr surpassed the maximum permissible concentration in muscle, followed by Zn in some species. Pb, Cu, and Cd presented concentratio...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.2002.4341
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Effects of prenatal Manganese (Mn) exposure at an environmental relevant level on neonatal neurodevelopment remains unclear. OBJECTIVES:In the multi-center study, we assessed the impact of low level prenatal Mn exposure on neonatal behavioral neurological assessments (NBNA), and explore a threshold umbilica...
journal_title:Environmental research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.envres.2014.04.012
更新日期:2014-08-01 00:00:00
abstract::High concentrations of uranium (mean=620 microg/L) were detected in water samples collected from private wells in a residential community. Based on isotopic analyses, the source of the uranium contamination appeared to be from naturally occurring geological deposits. In homes where well water concentrations of uranium...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/S0013-9351(03)00115-4
更新日期:2004-03-01 00:00:00
abstract::The effects of acrolein were studied on the chick embryos of 48 and 72 hr of incubation. Acrolein was dissolved in physiological saline and injected into the air sacs of the eggs at doses ranging from 0.001 to 0.1 mg per egg. The controls received and equal amount of saline only (0.1 ml per egg). All the embryos inclu...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(86)80006-8
更新日期:1986-02-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110054
更新日期:2020-12-01 00:00:00
abstract::A few epidemiologic studies suggest that exposure to bisphenol A (BPA) is associated with type 2 diabetes mellitus (T2DM). However, little is known about association between other phenolic endocrine disrupting chemicals (EDCs) and T2DM. In this case-control study, we measured urinary concentrations of 23 phenolic EDCs...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.06.040
更新日期:2018-10-01 00:00:00
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journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109185
更新日期:2020-04-01 00:00:00
abstract::The enhanced carcinogenicity of particle-associated polycyclic aromatic hydrocarbons (PAHs) has previously been explained by their prolonged retention in the lung due to the slow release of these substances from their carrier particles. However, the mathematical model presented here indicates that the lipid-aqueous he...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(87)80241-4
更新日期:1987-12-01 00:00:00
abstract::The aims of this study were (1) to explore the behavioral and sociodemographic factors influencing urinary cotinine (COT-U) levels in active smokers and in environmental tobacco smoke (ETS)-exposed individuals, (2) to assess the specificity and sensitivity of the questionnaire for identifying active smokers and nonsmo...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2016.03.029
更新日期:2016-07-01 00:00:00
abstract::The effects of calcium and magnesium ions on the toxicity of cadmium to the eggs of the freshwater teleost, Oryzias latipes, were determined. Blastulae were immersed in free medium (Ca- and Mg-free), low-Ca medium (0.25 mM Ca), high-Ca medium (1.0 mM Ca), low-Mg medium (0.25 mM Mg), and high-Mg medium (1.0 mM Mg) with...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(86)80087-1
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:Congenital limb deficiencies (CLDs) are a relatively common group of birth defects whose etiology is mostly unknown. Recent studies suggest maternal air pollution exposure as a potential risk factor. AIM:To investigate the relationship between ambient air pollution exposure during early pregnancy and offspr...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2019.108716
更新日期:2019-12-01 00:00:00
abstract::Penicillic acid (PA) is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. This mycotoxin is toxic in experimental animals and has also been reported to be carcinogenic. The cytotoxicity of penicillic acid was studied in rat alveolar macrophages (AM) in vitro. The effects of penicillic ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(86)80145-1
更新日期:1986-12-01 00:00:00
abstract::Heavy metals are an important class of environmental hazards, and as the use of heavy metals metals in industry continues to increase, larger segments of the biota, including human beings, will be exposed to increasing levels of these toxicants. As many heavy metals are mutagenic and clastogenic, they cause teratogeni...
journal_title:Environmental research
pub_type: 杂志文章,评审
doi:10.1016/0013-9351(85)90107-0
更新日期:1985-08-01 00:00:00
abstract::Athens is a city with a serious air pollution problem which has existed for more than 20 years. To evaluate whether air pollution has affected lung cancer incidence (and hence, mortality) in the population of Athens we have compared standardized lung mortality between Athens and the rest of Greece taking into account ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(87)80225-6
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:Both traffic-related noise and air pollution have been associated with cardiovascular disease (CVD). Spatial correlations between these environmental stressors may entail mutual confounding in epidemiological studies investigating their long-term effects. Few studies have investigated their correlation - non...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2010.10.013
更新日期:2011-01-01 00:00:00