Abstract:
:Ethylenediaminetetraacetic acid (EDTA) causes structural, biochemical and functional damage to blood platelets. The alterations induced are considered irreversible. However, the degree of irreversibility, and whether all functions are similarly compromised by EDTA have not been fully evaluated. The present study has examined platelets treated with EDTA to produce the structural changes in channels of the open canalicular system (OCS) associated with irreversible dissociation of the fibrinogen receptor, GPIIb-IIIa (alpha(IIb)beta(3)), for their ability to interact with particulates in suspension. Despite severe narrowing and near occlusion of peripherally oriented OCS channels by EDTA, treated cells were able to bind, translocate and take up fibrinogen-coated gold particles (Fgn/Au), colloidal gold and latex spheres. Thus exposure to EDTA may compromise some aspects of platelet function, but not others which may be important for participation in hemostatic events.
journal_name
Plateletsjournal_title
Plateletsauthors
White JG,Krumwiede MD,Escolar Gdoi
10.1080/09537109975979subject
Has Abstractpub_date
1999-01-01 00:00:00pages
327-37issue
5eissn
0953-7104issn
1369-1635pii
LVMUWEJG11YB9X4Mjournal_volume
10pub_type
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