Hydnellins A and B, nitrogen-containing Terphenyls from the mushrooms Hydnellum suaveolens and Hydnellum geogerirum.


:Fractionation of methanol extracts of the fruit bodies of two inedible mushrooms Hydnellum suaveolens and Hydnellum geogerirum (Thelephoraceae) resulted in isolation of two new p-terphenyl derivatives named hydnellins A and B and sarcodonin delta possessing N-oxide. Their structures were determined by 2D NMR, IR, UV spectroscopy, and chemical reaction. These terphenyls showed moderate antioxidant activity.


Hashimoto T,Quang DN,Kuratsune M,Asakawa Y




Has Abstract


2006-06-01 00:00:00














  • Functional analysis of the iron(II) etiocorrphycene incorporated in the myoglobin heme pocket.

    abstract::The iron(III) complex of 2,7,12,17-tetraethyl-3,6,11,18-tetra-methylcorrphycene, an isomeric heme, was complexed with apomyoglobin to examine the ligand binding ability of the novel macrocycle under physiological conditions. The reconstituted holoprotein was found to be functionally active at pH 7.4 and 20 degrees C a...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Neya S,Nakamura M,Imai K,Funasaki N

    更新日期:2001-03-01 00:00:00

  • Synthetic study of optically active 3-azabicyclo[3.3.0]octane-2,6,8-tricarboxylic acid.

    abstract::Synthesis of (1R,2S,5S,6R,8S)-3-azabicyclo[3.3.0]octane-2,6,8-tricarboxylic acid (2) from trans-4-hydroxy-L-proline (5) was attempted. A Diels-Alder reaction of 3,4-dehydroproline derivative 9 and cyclopentadiene afforded a single stereoisomer 11. The Diels-Alder adduct was smoothly converted to the hydrochloride of 2...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Arakawa Y,Ohnishi M,Yoshimura N,Yoshifuji S

    更新日期:2003-08-01 00:00:00

  • Effect of grinding with hydroxypropyl cellulose on the dissolution and particle size of a poorly water-soluble drug.

    abstract::A new benzofuroquinoline derivative, 3,9-bis(N,N-dimethylcarbamoyloxy)-5H-benzofuro[3,2-c]quinoli ne-6-one (KCA-098), shows poor oral absorption due to practical insolubility in water. In this study, a co-grinding technique employing a water-soluble polymer was used for improvement of the dissolution rate of KCA-098. ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yamada T,Saito N,Imai T,Otagiri M

    更新日期:1999-09-01 00:00:00

  • Synthesis and evaluation of (piperidinomethylene)bis(phosphonic acid) derivatives as anti-osteoporosis agents.

    abstract::Some (piperidinomethylene)bis(phosphonic acid) derivatives were prepared and their activity to inhibit a rise in serum calcium induced by parathyroid hormone in thyroparathyroidectomised rats was evaluated. Several (4-alkylidene-, 4,4-dialkyl-, or 4-alkyl-4-halopiperidinomethylene)bis(phosphonic acid) derivatives show...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Mimura M,Hayashida M,Nomiyama K,Ikegami S,Iida Y,Tamura M,Hiyama Y,Ohishi Y

    更新日期:1993-11-01 00:00:00

  • Single and multi-layered nanofibers for rapid and controlled drug delivery.

    abstract::This paper introduces a new delivery system for rapid and controlled drug release. Mixture of hydrophilic, (poly vinyl alcohol, PVA, and randomly methylated beta-cyclodextrin, RM beta-CD), and hydrophobic (poly D,L-lactide, PLA, and poly D,L-lactide-co-glycoside, PLGA) polymers were electrospun to make a multi-layered...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Fathi-Azarbayjani A,Chan SY

    更新日期:2010-02-01 00:00:00

  • Inner-hydrogen tautomerism in some 5,15-unsymmetrically disubstituted and beta-unsubstituted porphyrins.

    abstract::5,15-Unsymmetrically disubstituted and beta-unsubstituted porphyrins such as 5-R, 15-(3,5-dimethoxyphenyl) porphyrins [where R=2-benzyloxy-1-naphthyl (1), 2-(2-naphthylmethoxy)-1-naphthyl (2), anthryl (3), or 2,4,6-triphenylphenyl (4)] and 5-(2-benzyloxy-1-naphthyl), 10,15,20-tri(3,5-dimethoxyphenyl) porphyrin (1') we...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Tohara A,Sato M

    更新日期:2008-07-01 00:00:00

  • Bitterness-Suppressing Effect of Umami Dipeptides and Their Constituent Amino Acids on Diphenhydramine: Evaluation by Gustatory Sensation and Taste Sensor Testing.

    abstract::Diphenhydramine, a sedating antihistamine, is an agonist of human bitter taste receptor 14 (hTAS2R14). Diphenhydramine hydrochloride (DPH) was used as a model bitter medicine to evaluate whether the umami dipeptides (Glu-Glu and Asp-Asp) and their constituent amino acids (Glu, Asp) could suppress its bitterness intens...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Okuno T,Morimoto S,Nishikawa H,Haraguchi T,Kojima H,Tsujino H,Arisawa M,Yamashita T,Nishikawa J,Yoshida M,Habara M,Ikezaki H,Uchida T

    更新日期:2020-01-01 00:00:00

  • Calculation of membrane potential in synaptosomes with use of a lipophilic cation (tetraphenylphosphonium).

    abstract::To estimate membrane potential in synaptosomes with the use of tetraphenylphosphonium (TPP+), an equation relating the amount of TPP+ accumulated in synaptosomes with membrane potential was derived from the following two assumptions. (1) TPP+ molecules were distributed into plasma membranes, mitochondria and cytosol o...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Aiuchi T,Matsunaga M,Nakaya K,Nakamura Y

    更新日期:1989-12-01 00:00:00

  • Cytotoxic triterpenoid saponins from the roots of Cephalaria gigantea.

    abstract::Three new oleanane-type saponins, giganteosides L (1), M (2) and N (3) along with eight known ones were isolated from the roots of Cephalaria gigantea. Their structures were established as 3-O-[beta-D-galactopyranosyl-(1-->2)-beta-D-glucuronopyranosyl]-28-O-[beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl]-oleanol...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Tabatadze N,Elias R,Faure R,Gerkens P,De Pauw-Gillet MC,Kemertelidze E,Chea A,Ollivier E

    更新日期:2007-01-01 00:00:00

  • New progesterone esters as 5alpha-reductase inhibitors.

    abstract::The pharmacological activity of four new progesterone derivatives: 4-bromo-17alpha-(p-fluorobenzoyloxy)-4-pregnene-3,20-dione (7), 4-bromo-17alpha-(p-bromobenzoyloxy)-4-pregnene-3,20-dione (8), 4-bromo-17alpha-(p-chlorobenzoyloxy)-pregnene-3,20-dione (9) and 4-bromo-17alpha-(p-toluoyloxy)-4-pregnene-3,20-dione (10) wa...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Cabeza M,Heuze I,Bratoeff E,Murillo E,Ramirez E,Lira A

    更新日期:2001-09-01 00:00:00

  • Change of ras-transformed NRK-cells back to normal morphology by mycalamides A and B, antitumor agents from a marine sponge.

    abstract::Mycalamide A and mycalamide B, isolated as antiviral and antitumor agents from a New Zealand sponge of the genus Mycale, converted the morphology of ras-transformed NRK-cells to normal morphology at 10 and 1 ng/ml, respectively. The effect on protein synthesis suggests that these agents converted the morphology by pre...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ogawara H,Higashi K,Uchino K,Perry NB

    更新日期:1991-08-01 00:00:00

  • An artificial copper complex incorporating a cell-penetrating peptide inhibits nuclear factor-κB (NF-κB) activation.

    abstract::Nuclear factor-κB (NF-κB) is an inducible transcription factor activated by a variety of cytokines, and promotes the transcription of genes involved in cancer, inflammation, autoimmune disease, and viral infection, among others. Because of its involvement in numerous disease processes, considerable research has focuse...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kanemaru Y,Momiki Y,Matsuura S,Horikawa T,Gohda J,Inoue J,Okamoto Y,Fujita M,Otsuka M

    更新日期:2011-01-01 00:00:00

  • Steroidal glycosides from the fruits of Solanum viarum.

    abstract::Three new steroidal glycosides, named solaviasides A, B, and C, have been isolated from the fruits of Solanum viarum DUNAL (syn. S. khasianum var. chatterjeeanum, Solanaceae), along with seven known ones. Their chemical structures were determined on the basis of spectroscopic data and chemical evidence. ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ono M,Kakiuchi T,Ebisawa H,Shiono Y,Nakamura T,Kai T,Ikeda T,Miyashita H,Yoshimitsu H,Nohara T

    更新日期:2009-06-01 00:00:00

  • A novel method for estimation of transition temperature for polymorphic pairs in pharmaceuticals using heat of solution and solubility data.

    abstract::A novel method for thermodynamic stability studies of polymorphic drug substances has been developed. In order to estimate the transition temperature for an enantiotropic polymorphic pair, a formula for calculating the temperature at which the solubilities of each polymorph become equal has been derived with heat of s...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Urakami K,Shono Y,Higashi A,Umemoto K,Godo M

    更新日期:2002-02-01 00:00:00

  • Studies on antibacterial agents. I. Synthesis of substituted 6,7-dihydro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acids.

    abstract::A series of substituted 6,7-dihydro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acids was synthesized and tested for antibacterial activities. Among them, 9-fluoro-6,7-dihydro-5-methyl-8-(4-methyl-1-piperazinyl)-1-oxo-1H,5H- benzo[i,j]quinolizine-2-carboxylic acid (OPC-7241) exhibited potent antibacterial activity ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ishikawa H,Tabusa F,Miyamoto H,Kano M,Ueda H,Tamaoka H,Nakagawa K

    更新日期:1989-08-01 00:00:00

  • Acyclic sulfides, garlicnins L-1-L-4, E, and F, from Allium sativum.

    abstract::Six novel acyclic sulfides, named garlicnins L-1-L-4 (1-4), E (5), and F (6), were isolated from the acetone extracts, with the ability to suppress M2 macrophage activation, of the bulbs of garlic (Allium sativum L.), and their chemical structures were characterized. ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nohara T,Fujiwara Y,Ikeda T,Yamaguchi K,Manabe H,Murakami K,Ono M,Nakano D,Kinjo J

    更新日期:2014-01-01 00:00:00

  • Tryptanthrin-loaded nanoparticles for delivery into cultured human breast cancer cells, MCF7: the effects of solid lipid/liquid lipid ratios in the inner core.

    abstract::Tryptanthrin is an ancient medicine which recently was also found to have a function of downregulating multidrug resistance (MDR). However, tryptanthrin is insoluble in water, which limits its availability for delivery into cancer cells. There is a need to improve delivery systems to increase the inhibition of MDR. Th...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Fang YP,Lin YK,Su YH,Fang JY

    更新日期:2011-01-01 00:00:00

  • Novel 4-phenoxy-2-(1-piperazinyl)quinazolines as potent anticonvulsive and antihypoxic agents.

    abstract::A series of 4-phenoxy-2-(1-piperazinyl)quinazolines was synthesized and examined for anticonvulsive and antihypoxic activities. Many of the compounds exhibited potent anticonvulsive activity comparable to that of carbamazepine or phenytoin. Among them, 4-phenoxy-2-(4-propyl-1-piperazinyl)quinazoline (5w) was selected ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Hori M,Iemura R,Hara H,Ozaki A,Sukamoto T,Ohtaka H

    更新日期:1990-03-01 00:00:00

  • First total syntheses of (+/-)-isopiline, (+/-)-preocoteine, (+/-)-oureguattidine and (+/-)-3-methoxynordomesticine and the biological activities of (+/-)-3-methoxynordomesticine.

    abstract::A convenient and economical synthesis of 4-hydroxy-2,3-dimethoxybenzaldehyde has been developed. This was used as the starting material for the first total syntheses of (+/-)-isopiline, (+/-)-preocoteine, (+/-)-oureguattidine and (+/-)-3-methoxynordomesticine in which the key step involved formation of ring C of the a...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nimgirawath S,Udomputtimekakul P,Taechowisan T,Wanbanjob A,Shen Y

    更新日期:2009-04-01 00:00:00

  • Synthesis and evaluation of pyrrolin-2-one compounds, a series of plasminogen activator inhibitor-1 inhibitors.

    abstract::A novel series of furan-2-one and pyrrolin-2-one derivatives having PAI-1 (plasminogen activator inhibitor-1) inhibitory activity were synthesized and evaluated for their antithrombotic activity in a rat arterial thrombosis model. Among the synthesized compounds, 5f (T-1776Na) was found to have good selectivity for PA...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Miyazaki H,Ogiku T,Sai H,Moritani Y,Ohtani A,Ohmizu H

    更新日期:2009-09-01 00:00:00

  • Studies on cognitive enhancing agents. I. Antiamnestic and antihypoxic activities of 2-dimethylaminoethyl ethers and related compounds.

    abstract::N-(2-Dimethylaminoethyl)carboxamide (1a-d), 2-dimethylaminoethyl alkyl ether (2a, b), and 2-dimethylaminoethyl 2-hydroxy-2-phenethyl ether (3a-c) and its amino and methylene analogues (3d, 4) have been screened for antiamnestic and antihypoxic activities in mice. A clear reversing effect on electroconvulsive shock-ind...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ono S,Yamafuji T,Chaki H,Todo Y,Maekawa M,Kitamura K,Tai M,Narita H

    更新日期:1995-09-01 00:00:00

  • Prediction of the stability of meropenem in intravenous mixtures.

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Takasu Y,Yoshida M,Tange M,Asahara K,Uchida T

    更新日期:2015-01-01 00:00:00

  • Inducer-specific regulators of tumor necrosis factor alpha production.

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Miyachi H,Azuma A,Hioki E,Kobayashi Y,Iwasaki S,Hashimoto Y

    更新日期:1996-10-01 00:00:00

  • Synthesis and biological evaluation of 1,2,3,4-tetrahydroisoquinoline derivatives as potent and selective M2 muscarinic receptor antagonists.

    abstract::A series of 1,2,3,4-tetrahydroisoquinoline derivatives containing the 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one skeleton were prepared and evaluated for their in vitro binding affinities to muscarinic receptors and for antagonism of bradycardia in vivo. Among them, compound 3f had the highest affinity for ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Watanabe T,Kinoyama I,Takizawa K,Hirano S,Shibanuma T

    更新日期:1999-05-01 00:00:00

  • QSPR prediction of aqueous solubility of drug-like organic compounds.

    abstract::A quantitative structure property relationship (QSPR) study was performed to develop a model that relates the structures of 150 drug organic compounds to their aqueous solubility (log S(w)). Molecular descriptors derived solely from 3D structure were used to represent molecular structures. A subset of the calculated d...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ghasemi J,Saaidpour S

    更新日期:2007-04-01 00:00:00

  • Synthesis of macromolecular prodrugs of procaine, histamine and isoniazid.

    abstract::The attachment of various drugs bearing -NH2 groups to poly-alpha,beta-aspartic acid as a biodegradable carrier afforded in good yields macromolecular prodrugs which were characterized with respect to composition and drug load by spectroscopic and analytical methods. N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydr...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Giammona G,Giannola LI,Carlisi B,Bajardi ML

    更新日期:1989-08-01 00:00:00

  • Importance of Proton-Coupled Electron Transfer from Natural Phenolic Compounds in Superoxide Scavenging.

    abstract::The superoxide O2(·-) scavenging reaction of (+)-catechin (Cat), quercetin (Que), rutin, and α-tocopherol (α-TOH) as natural phenolic compounds is investigated on the basis of electrochemical and ESR spectral measurements with the aid of density functional theory (DFT) calculations. Reversibility of the O2/O2(·-) redo...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nakayama T,Uno B

    更新日期:2015-01-01 00:00:00

  • Simultaneous determination of triterpene saponins in ginseng drugs by high-performance liquid chromatography.

    abstract::A HPLC method for the simultaneous determination of 11 triterpene saponins with four-type aglycones (protopanaxadiol, protopanaxatriol, ocotillol and oleanolic acid types) in Ginseng drugs was developed and validated. Using a gradient of acetonitrile and 10 mM K-phosphate buffer (pH 5.80) as the mobile phase and UV de...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Zhu S,Zou K,Cai S,Meselhy MR,Komatsu K

    更新日期:2004-08-01 00:00:00

  • Chemical constituents of Tupistra chinensis rhizomes.

    abstract::A new pregnane glycoside, a dibenzylbutyrolactone lignan, 5-hydroxymatairesinol dimethyl ether, and three new flavonoids, including one 8-methylflavan-3-ol, and two 8-methylflavones, together with five known flavonoids and two known alkaloids were isolated from the rhizomes of Tupistra chinensis. The structures of all...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Pan WB,Wei LM,Wei LL,Wu YC

    更新日期:2006-07-01 00:00:00

  • Development of environmentally benign organometallic catalysis for drug discovery and its application.

    abstract::We have developed a novel organometallic catalysis and applied it to drug discovery. Two new catalysts were found, ruthenium hydride with a nitrogen-containing heterocyclic carbene (A) and an organopalladium catalyst supported on a sulfur-terminated semiconductor, gallium arsenide (001) (B). Both catalysts are environ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章,评审


    authors: Arisawa M

    更新日期:2007-08-01 00:00:00