The orexin system regulates alcohol-seeking in rats.

Abstract:

:1. Orexin-containing neurons have been implicated in feeding, sleep-wake cycles and more recently in drug-seeking behaviour. 2. Pretreatment of alcohol-preferring (iP) rats with an orexin1 receptor antagonist (SB-334867, 20 mg kg(-1), intraperitoneally) completely abolished an olfactory cue-induced reinstatement of alcohol-seeking behaviour, and also attenuated alcohol responding under an operant fixed ratio regimen without affecting water responding. 3. The mRNA encoding orexin within the hypothalamus was expressed at a similar density in iP and non-preferring (NP) rats; chronic consumption of ethanol in iP rats did not significantly regulate the density of this expression, but did increase the area of expression within the lateral, but not medial, hypothalamus. 4. These data indicate that while orexin may not be implicated in the development of an alcohol preference, re-exposure of cues previously associated with alcohol availability is sufficient and adequate to activate orexin-containing neurons and drive reinstatement of alcohol-seeking.

journal_name

Br J Pharmacol

authors

Lawrence AJ,Cowen MS,Yang HJ,Chen F,Oldfield B

doi

10.1038/sj.bjp.0706789

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

752-9

issue

6

eissn

0007-1188

issn

1476-5381

pii

0706789

journal_volume

148

pub_type

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