Recent exposure to particulate matter and C-reactive protein concentration in the multi-ethnic study of atherosclerosis.


:Ambient levels of particulate matter have been linked to cardiovascular disease. The mechanisms mediating these associations are poorly understood. One candidate mechanism is inflammation. Using data from the Multi-Ethnic Study of Atherosclerosis (2000-2002), the authors investigated the relation between exposure to particulate matter of less than or equal to 2.5 microm in diameter (PM2.5) and C-reactive protein concentration in 5,634 persons aged 45-84 years who were free of cardiovascular disease. Data from US Environmental Protection Agency monitors were used to estimate PM2.5 exposures for the prior day, prior 2 days, prior week, prior 30 days, and prior 60 days. Only the 30-day and 60-day mean exposures showed a weak positive association with C-reactive protein, and confidence intervals were wide: relative increases in C-reactive protein per 10 microg/m3 of PM2.5 adjusted for person-level covariates were 3% (95% confidence interval (CI): -2, 10) for a 30-day mean and 4% (95% CI: -3, 11.0) for a 60-day mean. The means of 7-day, 30-day, and 60-day exposures were weakly, positively, and nonsignificantly associated with the odds of C-reactive protein of greater than or equal to 3 mg/liter: adjusted odds ratios were 1.05 (95% CI: 0.96, 1.15), 1.12 (95% CI: 0.98, 1.29), and 1.12 (95% CI: 0.96, 1.32), respectively. Slightly stronger associations were observed in persons without other risk factors for elevated C-reactive protein, but this heterogeneity was not statistically significant. The authors' results are not compatible with strong effects of particulate matter exposures on population levels of C-reactive protein.


Am J Epidemiol


Diez Roux AV,Auchincloss AH,Astor B,Barr RG,Cushman M,Dvonch T,Jacobs DR Jr,Kaufman J,Lin X,Samson P




Has Abstract


2006-09-01 00:00:00














  • Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: the HUNT study.

    abstract::Experimental studies suggest that vitamin D modulates the activity of adipocytes. The authors examined baseline serum 25-hydroxyvitamin D (25(OH)D) level in relation to prevalent and cumulative incident obesity in Norway. A cohort of 25,616 adults aged 19-55 years participated in both the second and third surveys of t...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Mai XM,Chen Y,Camargo CA Jr,Langhammer A

    更新日期:2012-05-15 00:00:00

  • Performance of Disease Risk Score Matching in Nested Case-Control Studies: A Simulation Study.

    abstract::In a case-control study, matching on a disease risk score (DRS), which includes many confounders, should theoretically result in greater precision than matching on only a few confounders; however, this has not been investigated. We simulated 1,000 hypothetical cohorts with a binary exposure, a time-to-event outcome, a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Desai RJ,Glynn RJ,Wang S,Gagne JJ

    更新日期:2016-05-15 00:00:00

  • Are children living near high-voltage power lines at increased risk of acute lymphoblastic leukemia?

    abstract::In the National Cancer Institute/Children's Cancer Group case-control study of childhood acute lymphoblastic leukemia (1989-1993), living in a home with a high-voltage wire code was not associated with disease risk. To further investigate risk near power lines, the authors analyzed distance to transmission and three-p...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,多中心研究


    authors: Kleinerman RA,Kaune WT,Hatch EE,Wacholder S,Linet MS,Robison LL,Niwa S,Tarone RE

    更新日期:2000-03-01 00:00:00

  • Body mass index categories in observational studies of weight and risk of death.

    abstract::The World Health Organization (Geneva, Switzerland) and the National Heart, Lung, and Blood Institute (Bethesda, Maryland) have developed standard categories of body mass index (BMI) (calculated as weight (kg)/height (m)(2)) of less than 18.5 (underweight), 18.5-24.9 (normal weight), 25.0-29.9 (overweight), and 30.0 o...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,meta分析


    authors: Flegal KM,Kit BK,Graubard BI

    更新日期:2014-08-01 00:00:00

  • Observations on the history of epidemiology in western New York, 1843-1960.

    abstract::Epidemiology has a rich tradition in western New York State, beginning with the classic study by Austin Flint of a waterborne typhoid fever outbreak in North Boston in 1843. Other important investigations included the study of the Buffalo poliomyelitis epidemic of 1912, by Wade Hampton Frost, which provided a comprehe...

    journal_title:American journal of epidemiology

    pub_type: 历史文章,杂志文章


    authors: Winkelstein W Jr

    更新日期:1997-12-01 00:00:00

  • Validation of a method to estimate age-specific human immunodeficiency virus (HIV) incidence rates in developing countries using population-based seroprevalence data.

    abstract::The authors have conducted an analysis to validate a computer model that uses age-specific human immunodeficiency virus (HIV) prevalence data to estimate age-specific HIV incidence rates. Data for the analysis are from a cohort study of volunteer male workers in Bujumbura, the capital city of Burundi. Testing for HIV ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Saidel T,Sokal D,Rice J,Buzingo T,Hassig S

    更新日期:1996-08-01 00:00:00

  • Cardiovascular risk factor prevention in black schoolchildren: two-year results of the "Know Your Body" program.

    abstract::A five-year intervention study of the effectiveness of the "Know Your Body" program in reducing coronary heart disease risk factors among black students in the District of Columbia, who were in grades 4-6 at baseline, was begun in 1983. Nine schools were stratified on socioeconomic status and randomly assigned to cont...

    journal_title:American journal of epidemiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bush PJ,Zuckerman AE,Theiss PK,Taggart VS,Horowitz C,Sheridan MJ,Walter HJ

    更新日期:1989-03-01 00:00:00

  • An analysis of excess mortality rates for persons with non-insulin-dependent diabetes mellitus in Western Australia using the Cox proportional hazards regression model.

    abstract::A cohort of 888 rural, nonaboriginal persons with non-insulin-dependent diabetes mellitus identified in Western Australia through surveys in 1978-1982 were followed for death until the end of 1986. A total of 257 deaths were observed. Excess mortality in this cohort as compared with the general Australian population w...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Knuiman MW,Welborn TA,Whittall DE

    更新日期:1992-03-15 00:00:00

  • Weight cycling and mortality in a large prospective US study.

    abstract::Weight cycling has been associated with an increased risk of death in some studies, but few studies differentiated weight cycling initiated by intentional weight loss from that initiated by illness. The association of weight cycling with death was examined among 55,983 men and 66,655 women in the Cancer Prevention Stu...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Stevens VL,Jacobs EJ,Sun J,Patel AV,McCullough ML,Teras LR,Gapstur SM

    更新日期:2012-04-15 00:00:00

  • Physical activity, obesity, energy intake, and the risk of non-Hodgkin's lymphoma: a population-based case-control study.

    abstract::The authors conducted a population-based case-control study of 1,030 cases with histologically confirmed, incident non-Hodgkin's lymphoma (NHL) and 3,106 controls to assess the impact of recreational physical activity, obesity, and energy intake on NHL risk in Canada from 1994 to 1997. Compared with those for subjects...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Pan SY,Mao Y,Ugnat AM,Canadian Cancer Registries Epidemiology Research Group.

    更新日期:2005-12-15 00:00:00

  • Perceived Interpersonal Discrimination and Older Women's Mental Health: Accumulation Across Domains, Attributions, and Time.

    abstract::Experiencing discrimination is associated with poor mental health, but how cumulative experiences of perceived interpersonal discrimination across attributes, domains, and time are associated with mental disorders is still unknown. Using data from the Study of Women's Health Across the Nation (1996-2008), we applied l...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,多中心研究


    authors: Bécares L,Zhang N

    更新日期:2018-05-01 00:00:00

  • The investigation of age at onset as a risk factor for mortality in persons with insulin-dependent diabetes mellitus using Cox proportional hazards models.

    abstract::Proportional hazards models measuring the effect of age at onset of insulin-dependent diabetes mellitus on mortality risk are presented. The study population consisted of 924 insulin-dependent diabetic patients who were seen within 1 year of diagnosis at Children's Hospital of Pittsburgh between 1950 and 1981 and were...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Kostraba JN,Dorman JS,LaPorte RE,Kuller LH,Orchard TJ,Becker DJ,Drash AL

    更新日期:1991-01-01 00:00:00

  • Women's Work-Family Histories and Cognitive Performance in Later Life.

    abstract::Long-term exposures to the stress and stimulation of different work, parenting, and partnership combinations might influence later life cognition. We investigated the relationship between women's work-family life histories and cognitive functioning in later life. Analyses were based on data from women born between 193...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Ice E,Ang S,Greenberg K,Burgard S

    更新日期:2020-09-01 00:00:00

  • Serum dioxin concentrations and thyroid hormone levels in the Seveso Women's Health Study.

    abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant. Although experimental evidence suggests that TCDD alters thyroid hormone levels in rodents, human data are inconsistent. In 1976, a trichlorophenol plant exploded in Seveso, Italy. Women living in highly exposed areas were followed t...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Chevrier J,Warner M,Gunier RB,Brambilla P,Eskenazi B,Mocarelli P

    更新日期:2014-09-01 00:00:00

  • Racial and Ethnic Disparities in the Incidence of Esophageal Cancer in the United States, 1992-2013.

    abstract::Racial and ethnic disparities in the incidence of esophageal cancer have not been thoroughly characterized with quantitative health-disparity measures. Using data from 1992-2013 from 13 US cancer registries in the Surveillance, Epidemiology, and End Results database, we assessed such disparities according to histologi...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Xie SH,Rabbani S,Petrick JL,Cook MB,Lagergren J

    更新日期:2017-12-15 00:00:00

  • Customized versus population-based birth weight charts for the detection of neonatal growth and perinatal morbidity in a cross-sectional study of term neonates.

    abstract::Customized birth weight charts that incorporate maternal characteristics are now being adopted into clinical practice. However, there is controversy surrounding the value of these charts in the prediction of growth and perinatal outcomes. The objective of this study was to assess the use of customized charts in predic...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Carberry AE,Raynes-Greenow CH,Turner RM,Jeffery HE

    更新日期:2013-10-15 00:00:00

  • Characteristics of leisure time physical activity associated with decreased risk of premature all-cause and cardiovascular disease mortality in middle-aged men.

    abstract::The association between leisure time physical activity and the risk of all-cause and cardiovascular disease mortality was analyzed in a Finnish cohort of 1,072 men age 35-63 years who were followed up for 10 years and 10 months. During the period, 168 deaths were recorded, 93 of which were the result of cardiovascular...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Haapanen N,Miilunpalo S,Vuori I,Oja P,Pasanen M

    更新日期:1996-05-01 00:00:00

  • Air pollution and hospital admissions for cardiovascular disease in Detroit, Michigan.

    abstract::In the December 1952 smog disaster in London, a substantial increase in mortality was closely associated with the increase in air pollution. Deaths from cardiovascular causes were elevated as well as respiratory deaths. The increase was greatest in the elderly. Hospital admissions were increased for both respiratory a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Schwartz J,Morris R

    更新日期:1995-07-01 00:00:00

  • Some epidemiologic features of motorcycle collision injuries. II. Factors associated with severity of injuries.

    abstract::Male drivers sustained relatively more serious motorcycle collision injuries than did male passengers, female drivers, or female passengers. For male drivers, severity of injury was related to age. The relative frequency of serious head injury was highest for drivers not wearing helmets who were involved in collisions...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Kraus JF,Riggins RS,Franti CE

    更新日期:1975-07-01 00:00:00

  • Experiences of Discrimination and Incident Type 2 Diabetes Mellitus: The Multi-Ethnic Study of Atherosclerosis (MESA).

    abstract::Experiences of discrimination are associated with increased risk of adverse health outcomes; however, it is unknown whether discrimination is related to incident type 2 diabetes mellitus (diabetes). We investigated the associations of major experiences of discrimination (unfair treatment in 6 situations) and everyday ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Whitaker KM,Everson-Rose SA,Pankow JS,Rodriguez CJ,Lewis TT,Kershaw KN,Diez Roux AV,Lutsey PL

    更新日期:2017-08-15 00:00:00

  • Retinal arteriolar diameters and elevated blood pressure: the Atherosclerosis Risk in Communities Study.

    abstract::Narrowing and other changes in retinal arterioles may reflect damage due to hypertension, which may predict stroke and other cardiovascular diseases independently of blood pressure level. Newly developed quantitative methods of assessing retinal narrowing are used to determine whether this sign is related only to curr...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Sharrett AR,Hubbard LD,Cooper LS,Sorlie PD,Brothers RJ,Nieto FJ,Pinsky JL,Klein R

    更新日期:1999-08-01 00:00:00

  • Personal sampling of particles in adults: relation among personal, indoor, and outdoor air concentrations.

    abstract::To investigate the validity of outdoor particulate matter with a 50% cutoff diameter of 10-microm (PM10) concentrations as a measure of exposure in time series studies, the association between personal and outdoor concentrations, within subjects, over time was investigated. Repeated measurements of personal, indoor, a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Janssen NA,Hoek G,Brunekreef B,Harssema H,Mensink I,Zuidhof A

    更新日期:1998-03-15 00:00:00

  • Physical activity during adulthood and adolescence in relation to renal cell cancer.

    abstract::Evidence for a relation between physical activity and renal cell cancer has been inconsistent. The authors examined physical activity in relation to renal cell cancer in a large, prospective US cohort study of 482,386 participants (289,503 men and 192,883 women) aged 50-71 years at baseline (1995-1996). At baseline, p...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Moore SC,Chow WH,Schatzkin A,Adams KF,Park Y,Ballard-Barbash R,Hollenbeck A,Leitzmann MF

    更新日期:2008-07-15 00:00:00

  • Psychosocial processes and cancer incidence among Japanese men in Hawaii.

    abstract::As part of the Honolulu Heart Program studies, 4,581 men of Japanese ancestry living in Hawaii completed a psychosocial questionnaire in 1971. By 1980, 280 new cancer cases had been recorded. Among 12 items related to stressful life situations, there were no consistent associations with total or site-specific cancer i...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Joffres M,Reed DM,Nomura AM

    更新日期:1985-04-01 00:00:00

  • Do genetic factors explain the association between poor oral health and cardiovascular disease? A prospective study among Swedish twins.

    abstract::Epidemiologic studies suggest positive associations between poor oral health and cardiovascular disease. The authors undertook a prospective study among 15,273 Swedish twins (1963-2000) to examine whether genetic factors underlying the 2 diseases could explain previous associations. They estimated hazard ratios and 95...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Mucci LA,Hsieh CC,Williams PL,Arora M,Adami HO,de Faire U,Douglass CW,Pedersen NL

    更新日期:2009-09-01 00:00:00

  • Short- and long-term prognosis after acute myocardial infarction in Chinese men and women.

    abstract::Most, but not all, studies in Western countries have indicated that women have a higher mortality than men after an acute myocardial infarction, but this has not been well documented in the developing world. The authors studied 601 male and 294 female myocardial infarction patients, aged 26-94 years, admitted to a cit...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: He J,Klag MJ,Whelton PK,Zhoa Y,Weng X

    更新日期:1994-04-01 00:00:00

  • Regression toward the mean in a two-stage selection program.

    abstract::A model for a two-stage selection program based upon normally distributed variables is examined. Subjects in the upper part of the distribution of first-stage observations are retained and subsequently observed an additional number of times in a second stage. Subjects in the upper part of the distribution of second-st...

    journal_title:American journal of epidemiology

    pub_type: 临床试验,杂志文章


    authors: McMahan CA

    更新日期:1982-08-01 00:00:00

  • Effects of temperature and snowfall on mortality in Pennsylvania.

    abstract::The relation between exposure to severe cold weather and mortality is examined in a retrospective study of deaths occurring during the month of January from 1991 to 1996 in Pennsylvania. Using division-days as units of observation (n = 1,560) aggregated from death certificates and geographic divisions, the authors est...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Gorjanc ML,Flanders WD,VanDerslice J,Hersh J,Malilay J

    更新日期:1999-06-15 00:00:00

  • Risk of other cancers following Kaposi's sarcoma: relation to acquired immunodeficiency syndrome.

    abstract::To evaluate the risk of another cancer among persons who initially developed Kaposi's sarcoma, the authors used data from the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute for the years 1973-1990. In persons under 70 years of age, 4,946 cases of Kaposi's sarcoma were obser...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Biggar RJ,Curtis RE,Cote TR,Rabkin CS,Melbye M

    更新日期:1994-02-15 00:00:00

  • The relation between body mass index and plasma total cholesterol in a multiracial sample of US schoolchildren.

    abstract::The relation between body mass index expressed as weight in kilograms divided by height in meters cubed (weight (kg)/height (m3)) and plasma total cholesterol was assessed in a sample of 11,389 US schoolchildren, aged 5-18 years, between 1984 and 1989. Among whites and Hispanics, a statistically significant nonlinear ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Resnicow K,Morabia A

    更新日期:1990-12-01 00:00:00