Abstract:
:Linkage of the gene responsible for an X-linked early onset parkinsonism disorder with mental retardation (McKusick 311510) to DNA probes that detect restriction fragment length polymorphisms is described. The disease gene is linked to the F8C gene, and to DNA probes detecting polymorphic loci DXS52, DXS15, DXS134, and DXS374 with maximum lod scores at theta = 0 of 5.08, 5.19, 5.00, 5.03, and 4.46, respectively. Multipoint linkage analysis gives a maximum multipoint lod score of 6.75 at the F8C gene. This places the disease gene in chromosomal region Xq27.3-qter.
journal_name
Genomicsjournal_title
Genomicsauthors
Gregg RG,Metzenberg AB,Hogan K,Sekhon G,Laxova Rdoi
10.1016/0888-7543(91)90363-jsubject
Has Abstractpub_date
1991-04-01 00:00:00pages
701-6issue
4eissn
0888-7543issn
1089-8646journal_volume
9pub_type
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