Erythrocyte survival in severe falciparum malaria.


:Erythrocyte survival was studied in 17 Thai patients (10 males, 7 females; aged 13-57 years) with severe falciparum malaria. To ensure radioisotopic labelling of cells before bone marrow recovery and survival analysis under near-steady state conditions, 51Cr labelling of autologous erythrocytes was performed at the time of admission (0 h) and calculation of mean cell lifespan (MCL) was based on semilogarithmic plots of corrected counts from 60 h onwards. Five patients received blood transfusions, all within 48 h of admission. The overall mean (+/- S.D.) MCL was short (44.1 +/- 21.7 days). Nontransfused patients had similar MCL values (43.6 +/- 20.4) to those of transfused patients (45.5 +/- 27.3 days, p greater than 0.8). Patients with and without palpable splenomegaly had MCL values which were not significantly different (54.1 +/- 28.8 vs. 37.2 +/- 12.3 days respectively, p greater than 0.1). There was no association between admission haematocrit or peripheral parasitaemia and MCL (p greater than 0.2 in each case), but there was an inverse correlation between total serum bilirubin and MCL (r = -0.49, p less than 0.025). There is accelerated destruction of non-parasitised erythrocytes in severe malaria resulting in a mean MCL that is half that found previously in healthy Thai volunteers (89.6 +/- 13.1 days, p less than 0.001) and significantly shorter than that reported previously in Thai patients with uncomplicated P. falciparum infections studied after parasite clearance (56.8 +/- 10.2 days, p less than 0.05).


Acta Trop


Acta tropica


Looareesuwan S,Davis TM,Pukrittayakamee S,Supanaranond W,Desakorn V,Silamut K,Krishna S,Boonamrung S,White NJ




Has Abstract


1991-02-01 00:00:00














  • First report of equine Pegivirus in South America, Brazil.

    abstract::The human Pegivirus (HPgV, also known as GBV-C virus or hepatitis G virus) is a lymphotropic RNA-virus phylogenetically related to the Hepatitis C virus, which infects approximately 5% of the world's human population. Recently, two novel, presumably hepatotropic, pegiviruses, designated as equine Pegivirus (EPgV) and ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: de Souza AJS,Malheiros AP,de Sousa ERP,Moreira ACN,Silva AL,das Chagas AAC,Freitas PEB,Gemaque BS,de Figueiredo HF,de Sá LRM,Dos Santos PDE,Soares MDCP

    更新日期:2015-12-01 00:00:00

  • The pharmacodynamic study of a potent new antimalarial (MC1).

    abstract::2,3-bis(Trifluoromethyl)-4-(3-hydroxyquinuclidinylquinoline) or MC(1) is a new synthetic compound with potent antimalarial activity in vitro and in vivo studies. The IC(50) values of MC(1) and chloroquine in in vitro culture of Plasmodium falciparum are 7.0x10(-8) and 6.06x10(-7)M, respectively. In an in vivo study us...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Satayavivad J,Watcharasit P,Khamkong P,Tuntawiroon J,Pavaro C,Ruchirawat S

    更新日期:2004-02-01 00:00:00

  • Geographic variation of Trypanosoma cruzi discrete typing units from Triatoma infestans at different spatial scales.

    abstract::We assessed the diversity and distribution of Trypanosoma cruzi discrete typing units (DTU) in Triatoma infestans populations and its association with local vector-borne transmission levels at various geographic scales. At a local scale, we found high predominance (92.4%) of TcVI over TcV in 68 microscope-positive T. ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Fernández Mdel P,Cecere MC,Lanati LA,Lauricella MA,Schijman AG,Gürtler RE,Cardinal MV

    更新日期:2014-12-01 00:00:00

  • Factors associated with dog rabies immunisation status in Bamako, Mali.

    abstract::We conducted a cross-sectional survey in Bamako, Mali, to determine for the first time the seroprevalence of rabies virus antibodies in the dog population and people's knowledge, attitudes and practices (KAP) towards the disease and its control. Antibody detection was done with the fluorescent antibody virus neutralis...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Mauti S,Traoré A,Hattendorf J,Schelling E,Wasniewski M,Schereffer JL,Zinsstag J,Cliquet F

    更新日期:2017-01-01 00:00:00

  • Diversity of digenean trematode larvae in snails from Lake Victoria, Kenya: First reports and bioindicative aspects.

    abstract::This study investigated the occurrence of digenean trematode larvae in snails from the Kenyan part of Lake Victoria. The survey included caenogastropod snails that have received less focus in parasitological studies in Africa: their trematodes are largely unknown. Out of 1145 snail specimens, 149 (13.0%) were infected...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Outa JO,Sattmann H,Köhsler M,Walochnik J,Jirsa F

    更新日期:2020-06-01 00:00:00

  • Screening and identification of a human domain antibody against Brucella abortus VirB5.

    abstract::Brucellosis is caused by the genus Brucella. Brucella is widely distributed in cattle, swine, sheep, goat and other mammals including human. Animal brucellosis causes severe economic losses and affects related international transportation and trade. Human brucellosis causes both acute and chronic symptoms of multi-org...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Deng H,Zhou J,Gong B,Xiao M,Zhang M,Pang Q,Zhang X,Zhao B,Zhou X

    更新日期:2019-09-01 00:00:00

  • Clinical presentation and treatment outcome of sleeping sickness in Sudanese pre-school children.

    abstract:BACKGROUND:Existing data on human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense among children are limited. Here, we described the demographic, clinical, diagnostic, treatment and outcome characteristics of HAT in pre-school children from Kajo-Keji County, South Sudan in comparison with older patien...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Eperon G,Schmid C,Loutan L,Chappuis F

    更新日期:2007-01-01 00:00:00

  • Risk of infection with Brucella abortus and Escherichia coli O157:H7 associated with marketing of unpasteurized milk in Kenya.

    abstract::As part of a study to assess zoonotic milk-borne health risks, seasonal survey data and unpasteurized milk samples were collected between January 1999 and February 2000 from randomly selected informal milk market agents (220 and 236 samples in the dry and wet seasons, respectively) and from households purchasing raw m...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Arimi SM,Koroti E,Kang'ethe EK,Omore AO,McDermott JJ

    更新日期:2005-10-01 00:00:00

  • The sensitivity of axenic 200:NIH Entamoeba histolytica to bacitracin and its zinc salt.

    abstract::This study extends the previous knowledge of the action of bacitracin zinc against xenic cultures of Entamoeba histolytica. Results presented here, using axenic E. histolytica, confirm the enhanced activity of bacitracin zinc as compared to native bacitracin and demonstrate that this enhancement is due to a direct eff...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Andrews BJ

    更新日期:1994-06-01 00:00:00

  • Diatomaceous earth and oil enhance effectiveness of Metarhizium anisopliae against Triatoma infestans.

    abstract::Entomopathogenic fungi, especially Metarhizium anisopliae, have potential for integrated control of peridomestic triatomine bugs. However, the high susceptibility of these vectors to fungal infection at elevated ambient humidities decreases in the comparatively dry conditions that often prevail in their microhabitats....

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Luz C,Rodrigues J,Rocha LF

    更新日期:2012-04-01 00:00:00

  • Molecular variation in Leishmania.

    abstract::The surface coat of the protozoan parasite Leishmania affords remarkable protection in the harsh environments encountered within the insect vectors and vertebrate hosts. It also provides specificity for the interaction of these parasites with the cells in the sandfly gut and with the human macrophage. Surprisingly few...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Moody SF

    更新日期:1993-05-01 00:00:00

  • Molecular and phylogenetic analysis of a novel salivary defensin cDNA from malaria vector Anopheles stephensi.

    abstract::Manipulating the endogenous immune responses of the mosquito such as temporal and spatial expression of antimicrobial peptides may help in the development of a refractory mosquito, unable to transmit malaria. In mosquito several small antimicrobial peptides are activated locally in the midgut and salivary glands upon ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Dixit R,Sharma A,Patole MS,Shouche YS

    更新日期:2008-04-01 00:00:00

  • Methods to sustain drug efficacy in helminth control programmes.

    abstract::Assessment of the efficacy of anthelminthic treatment in public health is a broad concept, which goes beyond parasitological methods and should be clearly defined according to several indicators of morbidity. Several factors may influence the efficacy of anthelminthic drugs. The quality of drug is an issue of great im...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Albonico M

    更新日期:2003-05-01 00:00:00

  • Trypanosoma congolense: re-expression of a deleted metacyclic variable antigen type in vivo and in vitro.

    abstract::The expression of variable antigen types (VATs) was determined among dividing populations of T. congolense growing in vivo in rabbit chancres and in vitro on bovine aorta endothelial cell monolayers. Experiments were performed in which a single metacyclic VAT (M-VAT) was deleted from a cultured metacyclic population b...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Sutherland DV,Ross CA,Luckins AG

    更新日期:1991-08-01 00:00:00

  • Environmental factors underlying spatial patterns of sand flies (Diptera: Psychodidae) associated with leishmaniasis in southern Sinai, Egypt.

    abstract::Although Leishmania major is endemic in parts of the Sinai of Egypt, the ecology and distribution of Leishmania sand fly vectors in southern Sinai has not been well characterized. Accordingly, additional sand fly samples were obtained at 41 sites in the southern Sinai region during 1996-1997, and analyzed to improve t...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Kassem HA,Siri J,Kamal HA,Wilson ML

    更新日期:2012-07-01 00:00:00

  • New Cryptosporidium parvum subtypes of IIa subfamily in dairy calves from Brazil.

    abstract::Bovine cryptosporidiosis is mainly caused by four distinct species: Cryptosporidium parvum, C. bovis, C. ryanae and C. andersoni. The first, C. parvum, is a major concern in livestock causing economic losses, in addition to public health impact because of its zoonotic characteristics. The present study aimed to determ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: do Couto MC,Lima Mde F,do Bomfim TC

    更新日期:2014-02-01 00:00:00

  • Comparative vectorial efficiency of Lutzomyia evansi and Lu. longipalpis for transmitting Leishmania chagasi.

    abstract::The infection rates and development of Leishmania chagasi in two sandfly species, Lutzomyia evansi and Lutzomyia longipalpis, were evaluated under natural and experimental conditions. Natural infection rates of Lu. evansi in San Andrés de Sotavento (Colombia) and Montañas de Peraza (Venezuela) (0.05 and 0.2%, respecti...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Montoya-Lerma J,Cadena H,Oviedo M,Ready PD,Barazarte R,Travi BL,Lane RP

    更新日期:2003-01-01 00:00:00

  • Imaging of cystic echinococcosis.

    abstract::This paper reviews various imaging techniques in different organs. Ultrasound is the most popular and readily available technique. Special emphasis is given to computerized tomography (CT) and magnetic resonance imaging (MRI) findings and their advantages for a confident diagnosis and treatment. ...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: von Sinner WN

    更新日期:1997-09-15 00:00:00

  • Epidemiology of brucellosis, Q Fever and Rift Valley Fever at the human and livestock interface in northern Côte d'Ivoire.

    abstract::Northern Côte d'Ivoire is the main livestock breeding zone and has the highest livestock cross-border movements in Côte d'Ivoire. The aim of this study was to provide updated epidemiological data on three neglected zoonotic diseases, namely brucellosis, Q Fever and Rift Valley Fever (RVF). We conducted three-stage cro...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Kanouté YB,Gragnon BG,Schindler C,Bonfoh B,Schelling E

    更新日期:2017-01-01 00:00:00

  • Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil.

    abstract:BACKGROUND:Black fly and sandfly bites are related to the endemicity of pemphigus foliaceus (PF); however, an immune reaction against the salivary proteins from these flies still requires confirmation in the case of PF patients living in southeastern Brazil. PURPOSE:To georeference the distribution of Simuliidae (Dipt...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Vernal S,Pepinelli M,Casanova C,Goulart TM,Kim O,De Paula NA,Pinto MC,Sá-Nunes A,Roselino AM

    更新日期:2017-12-01 00:00:00

  • Dengue endemic and its impact on the gross national product of BRAZILIAN'S economy.

    abstract::In history disease has caused social and economic damage. Dengue is an illness typically found in the tropics that has affected more and more people. In Brazil, according to the Brazilian Institute of Geography and Statistics (IBGE), in 2013 at least 12.9% of the population (25.8 million) reported already having had d...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Montibeler EE,Oliveira DR

    更新日期:2018-02-01 00:00:00

  • Minimal efficacy requirements for malarial vaccines to significantly lower transmission in epidemic or seasonal malaria.

    abstract::The effect of vaccines against the pre-erythrocytic, the erythrocytic and the sexual stages of malaria on the transmission of malaria was examined using a simulation model of seasonal or epidemic transmission. The primary outcome of the model was the number of cases of malaria present at the end of the transmission se...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Saul A

    更新日期:1993-01-01 00:00:00

  • Magnetic affinity enzyme-linked immunoassay based on recombinant 26 kDa glutathione-S-transferase for serological diagnosis of schistosomiasis japonica.

    abstract::Schistosomiasis remains a serious worldwide public health problem. Improving the diagnostic assay for surveillance and monitoring will contribute to hastening the possible elimination of the disease in endemic regions. Therefore, this study aims to develop magnetic affinity enzyme-linked immunoassay (MEIA) for serolog...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Yu Q,Yang H,Feng Y,Yang X,Zhu Y

    更新日期:2012-12-01 00:00:00

  • Female genital schistosomiasis (FGS): relationship between gynecological and histopathological findings.

    abstract::Schistosomiasis of the lower female reproductive tract manifests itself in a broad spectrum of clinical features. However, clinical and histopathological findings have never been studied in a synoptic manner. Based on the assumption that any type of pathology present in the female reproductive tract is the expression ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Helling-Giese G,Sjaastad A,Poggensee G,Kjetland EF,Richter J,Chitsulo L,Kumwenda N,Racz P,Roald B,Gundersen SG,Krantz I,Feldmeier H

    更新日期:1996-12-30 00:00:00

  • Effect of temperature and inter-specific competition on the development and survival of Anopheles gambiae sensu stricto and An. arabiensis larvae.

    abstract::The two major African malaria vectors Anopheles gambiae sensu stricto and An. arabiensis are sibling species that occupy different climatic niches but are frequently found in the same larval habitats. Differences in survival and development of the aquatic larval stages of these species at different temperatures may he...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Kirby MJ,Lindsay SW

    更新日期:2009-02-01 00:00:00

  • Epidemiology of human leptospirosis in Malaysia, 2004-2012.

    abstract::Leptospirosis is an emerging disease, especially in countries with a tropical climate such as Malaysia. A dramatic increase in the number of cases has been reported over the last decade; however, information on the epidemiological trends of this disease is lacking. The objective of this study is to provide an epidemio...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Benacer D,Thong KL,Min NC,Bin Verasahib K,Galloway RL,Hartskeerl RA,Souris M,Mohd Zain SN

    更新日期:2016-05-01 00:00:00

  • Neuroinvasion by Chandipura virus.

    abstract::Chandipura virus (CHPV) is an arthropod borne rhabdovirus associated with acute encephalitis in children below the age of 15 years in the tropical states of India. Although the entry of the virus into the nervous system is among the crucial events in the pathogenesis of CHPV, the exact mechanism allowing CHPV to invad...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Rajasekharan S,Rana J,Gulati S,Gupta V,Gupta S

    更新日期:2014-07-01 00:00:00

  • Immunogenetic influences on tick resistance in African cattle with particular reference to trypanotolerant N'Dama (Bos taurus) and trypanosusceptible Gobra zebu (Bos indicus) cattle.

    abstract::In sub-Saharan Africa, tick infestation and tick-borne infections together with tsetse-transmitted trypanosomosis arguably constitute the main parasitological disease complex constraining livestock production. Resistance to tick attack and tick-borne micro-organisms (TBMs) varies among different breeds of cattle. The ...

    journal_title:Acta tropica

    pub_type: 杂志文章,评审


    authors: Mattioli RC,Pandey VS,Murray M,Fitzpatrick JL

    更新日期:2000-05-31 00:00:00

  • Immune serum from both susceptible and resistant strains of mice increases phagocytosis of Leishmania mexicana amazonensis by macrophages.

    abstract::Immune sera obtained from either BALB/c mice (susceptible) at 7 weeks, or C57BL/6 mice (resistant), at 7 weeks after infection with L. m. amazonensis, were effective in increasing internalization of homologous promastigotes into starch-induced peritoneal macrophages (from both mouse strains). Both the internalization ...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: Reis MG,Roters SB,Barral-Netto M

    更新日期:1987-09-01 00:00:00

  • Multiple trypanosome infections in wild tsetse in Côte d'Ivoire detected by PCR analysis and DNA probes.

    abstract::Trypanosomes were isolated from the midguts of Glossina palpalis palpalis, G. pallicera pallicera and G. nigrofusca nigrofusca captured around the village of Guediboua, South West of Daloa in Côte d'Ivoire. Seventy of the 124 isolates, obtained from 688 flies, were examined for four different kinds of trypanosome usin...

    journal_title:Acta tropica

    pub_type: 杂志文章


    authors: McNamara JJ,Laveissière C,Masiga DK

    更新日期:1995-05-01 00:00:00