Mechanistic investigation and implications of photodynamic therapy induction of vascular endothelial growth factor in prostate cancer.

Abstract:

:Photodynamic therapy (PDT) is now an approved therapeutic modality, and induction of vascular endothelial growth factor (VEGF) following subcurative PDT is of concern as VEGF may provide a survival stimulus to tumors. The processes that limit the efficacy of PDT warrant investigation so that mechanism-based interventions may be developed. This study investigates VEGF increase following subcurative PDT using the photosensitizer benzoporphyrin derivative (BPD) both in an in vitro and in an orthotopic model of prostate cancer using the human prostate cancer cell line LNCaP. The two subcurative doses used, 0.25 and 0.5 J/cm(2), mimicked subcurative PDT and elicited a 1.6- and 2.1-fold increase, respectively, in secreted VEGF 24 hours following PDT. Intracellular VEGF protein measurement and VEGF mRNA showed a 1.4- and 1.6-fold increase only at 0.5 J/cm(2). In vivo subcurative PDT showed an increase in VEGF by both immunohistochemistry and ELISA. In vitro analysis showed no activation of hypoxia-inducible factor-1alpha (HIF-1alpha) or cyclooxygenase-2 (COX-2) following subcurative PDT; furthermore, small interfering RNA inhibition of HIF-1alpha and COX-2 inhibitor treatment had no effect on PDT induction of VEGF. PDT in the presence of phosphatidylinositol 3-kinase/AKT inhibitor or mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase inhibitor still induced VEGF. However, subcurative PDT increased phosphorylated p38 and stress-activated protein kinase/c-Jun NH(2)-terminal kinase. The p38 MAPK inhibitor abolished PDT induction of VEGF. The results establish the importance of VEGF in subcurative BPD-PDT of prostate cancer and suggest possible molecular pathways for its induction. These findings should provide the basis for the development of molecular-based interventions for enhancing PDT and merit further studies.

journal_name

Cancer Res

journal_title

Cancer research

authors

Solban N,Selbo PK,Sinha AK,Chang SK,Hasan T

doi

10.1158/0008-5472.CAN-06-0604

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

5633-40

issue

11

eissn

0008-5472

issn

1538-7445

pii

66/11/5633

journal_volume

66

pub_type

杂志文章
  • Differential behaviors toward ultraviolet A and B radiation of fibroblasts and keratinocytes from normal and DNA-repair-deficient patients.

    abstract::Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) are rare genodermatoses transmitted as recessive and autosomal traits that result in reduced capacity to repair UV-induced DNA lesions. Although XP, but not TTD, patients are prone to basal and squamous cell carcinomas, to date no comparative studies of the XP a...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Otto AI,Riou L,Marionnet C,Mori T,Sarasin A,Magnaldo T

    更新日期:1999-03-15 00:00:00

  • Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia.

    abstract::Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and constitutes 15% of adult leukemias. Although overall prognosis for pediatric ALL is favorable, high-risk pediatric patients and most adult patients have significantly worse outcomes. Multiagent chemotherapy is standard of care for both pedi...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-10-2238

    authors: Chao MP,Alizadeh AA,Tang C,Jan M,Weissman-Tsukamoto R,Zhao F,Park CY,Weissman IL,Majeti R

    更新日期:2011-02-15 00:00:00

  • Purification and identification of mouse lung microvessel endothelial cell-derived chemoattractant for lung-metastasizing murine RAW117 large-cell lymphoma cells: identification as mouse monocyte chemotactic protein 1.

    abstract::We reported recently that medium conditioned with mouse lung microvessel endothelial cells possessed chemotactic activity for a highly lung-metastatic variant (L17) of the RAW117 murine large-cell lymphoma cell line but not for the poorly metastatic parental cells (P) or a liver-metastasizing variant (H10). The chemot...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Wakabayashi H,Cavanaugh PG,Nicolson GL

    更新日期:1995-10-01 00:00:00

  • Quantitative metrics of net proliferation and invasion link biological aggressiveness assessed by MRI with hypoxia assessed by FMISO-PET in newly diagnosed glioblastomas.

    abstract::Glioblastoma multiforme (GBM) are aggressive and uniformly fatal primary brain tumors characterized by their diffuse invasion of the normal-appearing parenchyma peripheral to the clinical imaging abnormality. Hypoxia, a hallmark of aggressive tumor behavior often noted in GBMs, has been associated with resistance to t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-08-3884

    authors: Szeto MD,Chakraborty G,Hadley J,Rockne R,Muzi M,Alvord EC Jr,Krohn KA,Spence AM,Swanson KR

    更新日期:2009-05-15 00:00:00

  • CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.

    abstract::Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacologic targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. We previously discovered that CDK2 inhibition causes lung cancer cells with more than ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-14-1494

    authors: Hu S,Danilov AV,Godek K,Orr B,Tafe LJ,Rodriguez-Canales J,Behrens C,Mino B,Moran CA,Memoli VA,Mustachio LM,Galimberti F,Ravi S,DeCastro A,Lu Y,Sekula D,Andrew AS,Wistuba II,Freemantle S,Compton DA,Dmitrovsky E

    更新日期:2015-05-15 00:00:00

  • Androgen dependency of a tumor produced by a cell line derived from androgen-responsive Shionogi carcinoma 115.

    abstract::An androgen-dependent tumor (SCC8 tumor) was obtained by inoculating an androgen-responsive cell line derived from the androgen-responsive Shionogi carcinoma 115 (SC115) into mice and then treating the mice with testosterone propionate (TP) at a pharmacological dose (400 micrograms/day). The SCC8 tumor differed in his...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Terada N,Yamamoto R,Uchida N,Takada T,Taniguchi H,Takatsuka D,Sawada M,Tsuji M,Li W,Kitamura Y

    更新日期:1989-02-01 00:00:00

  • Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells.

    abstract::Paclitaxel has been shown to activate Raf-1 and cause phosphorylation of Bcl-2, which has been correlated with paclitaxel-induced apoptosis of cancer cells. In the present studies, we demonstrate that in human AML HL-60 cells that express Bcl-2 but little Bcl-xL (HL-60/neo cells), paclitaxel-induced phosphorylation of...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ibrado AM,Liu L,Bhalla K

    更新日期:1997-03-15 00:00:00

  • Effect of gestational development of lung tumor size and morphology in the mouse.

    abstract::Pregnant C3HeB/FeJ mice were treated with ethylnitrosourea (ENU) on one of gestation Days 10, 13, or 15 to determine if ENU treatment at different stages of gestation would result in qualitative or quantitative differences in lung tumors induced in the offspring. Lung tumors were counted and measured 6 mo after treatm...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Branstetter DG,Stoner GD,Budd C,Conran PB,Goldblatt PJ

    更新日期:1988-01-15 00:00:00

  • The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.

    abstract::Defects in a developmental signaling pathway involving mammalian homologues of the Drosophila segment polarity gene, patched (ptc) and its ligand, sonic hedgehog (shh), contribute to tumor formation in several tissues. Recently, a subset of medulloblastoma, the most common malignant brain tumor in children, was found ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Wetmore C,Eberhart DE,Curran T

    更新日期:2000-04-15 00:00:00

  • Macrophage delivery of an oncolytic virus abolishes tumor regrowth and metastasis after chemotherapy or irradiation.

    abstract::Frontline anticancer therapies such as chemotherapy and irradiation often slow tumor growth, but tumor regrowth and spread to distant sites usually occurs after the conclusion of treatment. We recently showed that macrophages could be used to deliver large quantities of a hypoxia-regulated, prostate-specific oncolytic...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-12-3056

    authors: Muthana M,Rodrigues S,Chen YY,Welford A,Hughes R,Tazzyman S,Essand M,Morrow F,Lewis CE

    更新日期:2013-01-15 00:00:00

  • Breast cancer stem cells: something out of notching?

    abstract::We and others have established that the developmental Notch receptor signaling pathway is active in breast cancer cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating the hierarchy of stem and progenitor cells in both normal and cancer epithelium has been elucida...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:10.1158/0008-5472.CAN-10-1559

    authors: Harrison H,Farnie G,Brennan KR,Clarke RB

    更新日期:2010-11-15 00:00:00

  • Estramustine depolymerizes microtubules by binding to tubulin.

    abstract::To investigate the mechanism of action of the antineoplastic drug estramustine, we compared its effects on human prostate cancer cells with those of vinblastine. At their respective concentrations that result in 50% inhibition of clonogenic growth, both drugs caused an accumulation of cells blocked at mitosis and simi...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Dahllöf B,Billström A,Cabral F,Hartley-Asp B

    更新日期:1993-10-01 00:00:00

  • SPARC/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines.

    abstract::Activation of the matrix metalloproteinase 2 (MMP-2) has been shown to play a major role in the proteolysis of extracellular matrix (ECM) associated with tumor invasion. Although the precise mechanism of this activation remains elusive, levels of the membrane type 1-MMP (MT1-MMP) at the cell surface and of the tissue ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Gilles C,Bassuk JA,Pulyaeva H,Sage EH,Foidart JM,Thompson EW

    更新日期:1998-12-01 00:00:00

  • Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents.

    abstract::DNA repair status is recognized as an important determinant of the clinical efficacy of cancer chemotherapy. To assess the role that a mammalian DNA glycosylase plays in modulating the toxicity and clastogenicity of the chemotherapeutic DNA cross-linking alkylating agents, we compared the sensitivity of wild-type muri...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Allan JM,Engelward BP,Dreslin AJ,Wyatt MD,Tomasz M,Samson LD

    更新日期:1998-09-01 00:00:00

  • Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas.

    abstract::Ependymomas and astrocytomas commonly have allelic losses of chromosome 22q, which suggests the presence of a glioma tumor suppressor gene on 22q. A candidate tumor suppressor gene on 22q is the neurofibromatosis 2 (NF2) gene since NF2 patients have an increased susceptibility to ependymomas and astrocytomas. Using si...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Rubio MP,Correa KM,Ramesh V,MacCollin MM,Jacoby LB,von Deimling A,Gusella JF,Louis DN

    更新日期:1994-01-01 00:00:00

  • Distinct structural domains within C19ORF5 support association with stabilized microtubules and mitochondrial aggregation and genome destruction.

    abstract::C19ORF5 is a sequence homologue of microtubule-associated proteins MAP1A/MAP1B of unknown function, except for its association with mitochondria-associated proteins and the paclitaxel-like microtubule stabilizer and candidate tumor suppressor RASSF1A. Here, we show that when overexpressed in mammalian cells the recomb...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-04-3865

    authors: Liu L,Vo A,Liu G,McKeehan WL

    更新日期:2005-05-15 00:00:00

  • Factors affecting the sensitivity of T-47D human breast cancer cells to tamoxifen.

    abstract::Cell proliferation kinetics during growth of an estrogen receptor-positive human breast carcinoma cell line, T-47D, was defined, and some factors which modify its response to tamoxifen were investigated in vitro. T-47D cells were estrogen responsive when grown in charcoal-stripped fetal calf serum, but the addition of...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Reddel RR,Murphy LC,Sutherland RL

    更新日期:1984-06-01 00:00:00

  • Induction of human monocyte susceptibility to lymphokine-activated killer cell lysis by granulocyte-macrophage colony-stimulating factor.

    abstract::We have recently reported that cultured human monocytes are susceptible to lysis by autologous lymphokine-activated killer (LAK) cells. In an attempt to modulate the sensitivity of monocytes to LAK-mediated lysis, monocytes were cultured in the presence of recombinant human granulocyte-macrophage colony-stimulating fa...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Blanchard DK,Serbousek D,Djeu JY

    更新日期:1989-09-15 00:00:00

  • Regional heterogeneity and complementation in the expression of the tumor-associated glycoprotein 72 epitopes in colorectal cancer.

    abstract::We analyzed the immunohistochemical expression of three epitopes of the tumor-associated glycoprotein 72 (TAG-72) in whole cross-sections of primary colorectal carcinomas and in regional lymph node metastases using monoclonal antibodies (MAbs) B72.3, CC-49, and CC-83, which recognize distinct carbohydrate antigenic de...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Muraro R,Frati L,Bei R,Ficari F,Valli C,French D,Mammarella S,Caramia F,Fegiz G,Mariani-Costantini R

    更新日期:1991-10-01 00:00:00

  • Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer.

    abstract::The increasing availability and maturity of DNA microarray technology has led to an explosion of cancer profiling studies. To extract maximum value from the accumulating mass of publicly available cancer gene expression data, methods are needed to evaluate, integrate, and intervalidate multiple datasets. Here we demon...

    journal_title:Cancer research

    pub_type: 杂志文章,meta分析

    doi:

    authors: Rhodes DR,Barrette TR,Rubin MA,Ghosh D,Chinnaiyan AM

    更新日期:2002-08-01 00:00:00

  • Recombinant human stem cell factor stimulates growth of a human glioblastoma cell line expressing c-kit protooncogene.

    abstract::The growth of a panel of eight different human glioblastoma cell lines was examined in a human tumor cloning assay in agar, a tritiated thymidine uptake assay, and by counting cell numbers, in cultures performed in the absence or presence of increasing concentrations (1 to 100 ng/ml) of recombinant human stem cell fac...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Berdel WE,de Vos S,Maurer J,Oberberg D,von Marschall Z,Schroeder JK,Li J,Ludwig WD,Kreuser ED,Thiel E

    更新日期:1992-06-15 00:00:00

  • Enhanced expression of the type II transforming growth factor beta receptor in human pancreatic cancer cells without alteration of type III receptor expression.

    abstract::We have recently found that human pancreatic adenocarcinomas exhibit strong immunostaining for the three mammalian transforming growth factor beta (TGF-beta) isoforms. These important growth-regulating polypeptides bind to a number of proteins, including the type I TGF-beta receptor (T beta R-I), type II TGF-beta rece...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Friess H,Yamanaka Y,Büchler M,Berger HG,Kobrin MS,Baldwin RL,Korc M

    更新日期:1993-06-15 00:00:00

  • Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo.

    abstract::Ligand-induced activation of peroxisome proliferator-activated receptor gamma (PPARgamma) inhibits proliferation in cancer cells in vitro and in vivo; however, the downstream targets remain undefined. We report the identification of a peroxisome proliferator response element in the promoter region of the Na(+)/H(+) tr...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-09-0219

    authors: Kumar AP,Quake AL,Chang MK,Zhou T,Lim KS,Singh R,Hewitt RE,Salto-Tellez M,Pervaiz S,Clément MV

    更新日期:2009-11-15 00:00:00

  • Adenine nucleotide transport in hepatoma mitochondria and its correlation with hepatoma growth rates and tumor size.

    abstract::Initial rates of [3H]adenosine diphosphate and [3H]adenosine triphosphate uptake were measured in mitochondria isolated from normal rat liver, regenerating liver, mouse hepatoma BW7756, and four Morris hepatomas (7777, 7800, 7794A, and 16) of varying degrees of malignancy. Results obtained demonstrate that (a) the app...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Barbour RL,Chan SH

    更新日期:1983-04-01 00:00:00

  • Altered cell cycle phase distributions in cultured human carcinoma cells partially depleted of polyamines by treatment with difluoromethylornithine.

    abstract::We have studied the effects of partial polyamine depletion, induced by treatment with alpha-difluoromethylornithine (DFMO) on cell cycle phase distributions in five cultured human carcinoma cell lines. We used flow cytometry of cells stained with chromomycin-A3 and computer analysis to measure phase distributions of t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Seidenfeld J,Block AL,Komar KA,Naujokas MF

    更新日期:1986-01-01 00:00:00

  • A gene expression signature of genetic instability in colon cancer.

    abstract::Genetic instability plays a central role in the development and progression of human cancer. Two major classes of genetic instability, microsatellite instability (MSI) and chromosome instability (microsatellite stable; MSS), are best understood in the context of colon cancer, where MSI tumors represent approximately 1...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-04-4163

    authors: Giacomini CP,Leung SY,Chen X,Yuen ST,Kim YH,Bair E,Pollack JR

    更新日期:2005-10-15 00:00:00

  • Global analysis of altered gene expressions during the process of esophageal squamous cell carcinogenesis in the rat: a study combined with a laser microdissection and a cDNA microarray.

    abstract::The genetic alterations that occur during esophageal tumorigenesis have yet to be determined. We previously established a Wister rat carcinogenesis model of esophageal squamous cell carcinoma. To understand more about the molecular mechanisms during carcinogenesis, we produced esophageal neoplastic lesions by administ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Nishida K,Mine S,Utsunomiya T,Inoue H,Okamoto M,Udagawa H,Hanai T,Mori M

    更新日期:2005-01-15 00:00:00

  • Effects of tumor promoters on the expression of a tumor-related multigenic set in human cells.

    abstract::We previously found that a minor subfraction of the human genomic DNA, corresponding to 2500-3000 nonrepetitive sequences of 3 kilobases each and designated as tumor-activated DNA (TaDNA) was transcriptionally active in Burkitt's lymphoma cells and almost inactive in normal lymphocytes growing in vitro following integ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hanania N,Castagna M,Shaool D,Zeliszewski D,Harel J

    更新日期:1985-12-01 00:00:00

  • Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells.

    abstract::The mechanism(s) by which high-linear energy transfer a particles, like those emitted by inhaled radon and radon daughters, cause lung cancer has not been elucidated. Conceivably, DNA damage that is induced by a particles may be mediated by the metabolic generation of reactive oxygen species (ROS), in addition to dire...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Narayanan PK,Goodwin EH,Lehnert BE

    更新日期:1997-09-15 00:00:00

  • The disposition and pharmacokinetics in humans of 5-azacytidine administered intravenously as a bolus or by continuous infusion.

    abstract::The disposition of 5-[4-14C]azacytidine, administered i.v. as a bolus or continuous infusion, was studied in cancer patients. After bolus, plasma 14C levels exhibited as multiphasic disappearance pattern; half-life (t1/2, beta phase) = 3.4 to 6.2 hr. Of 14C in plasma, less than 2% was associated with 5-[4-14C]azacytid...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Israili ZH,Vogler WR,Mingioli ES,Pirkle JL,Smithwick RW,Goldstein JH

    更新日期:1976-04-01 00:00:00