Association of CD45(dim)VLA-4 (+) cells with the NKT cell lineage and their selective expression of IL-13, IP-15, and CCR3 transcripts.

Abstract:

INTRODUCTION:Estrogen (E2) was shown to prevent experimental autoimmune encephalomyelitis (EAE) and to produce a novel population of regulatory CD45(dim)VLA-4(+) cells. Although their appearance was dependent upon an elevated hormonal level, E2 was not required for their production, as they also were induced by immunization with Mycobacterium tuberculosis as a component of complete Freund's adjuvant. MATERIALS AND METHODS:Molecular techniques, including ribonuclease protection assays and quantitative RT-PCR, were used to provide further characterization of CD45(dim)VLA-4(+) cells. Moreover, we determined the developmental requirements of the CD45(dim)VLA-4(+) cells using genetically modified mice and extensive flow cytometry analysis. RESULTS:Characterization of CD45(dim)VLA-4(+) mRNA profile revealed highly elevated levels of CD16, CD44, CCR3, IP-15, and IL-13 transcripts compared with their CD45(high)VLA-4(+) counterparts. Furthermore, we found up-regulation of anti-apoptotic bcl-w and bcl-xl genes and transcripts encoding the TCRalpha and CD8alpha homodimer. The production of CD45(dim)VLA-4(+) cells was evident in nude mice and in MHC class II- and beta2-microglobulin, but not in CD1-deficient mice, suggesting a crucial role for CD1 in their induction. CONCLUSIONS:These findings suggest that CD45(dim)VLA-4(+) cells might resemble natural killer T cells and imply possible roles for IL-13 and IP-15 in the protective function of CD45(dim)VLA-4(+) cells. A better understanding of how these cells, also occurring naturally during pregnancy, suppress the harmful immune response of EAE may lead to novel therapeutic approaches to combat multiple sclerosis and other autoimmune diseases.

authors

Matejuk A,Afentoulis M

doi

10.1007/s00005-006-0021-3

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

183-91

issue

3

eissn

0004-069X

issn

1661-4917

journal_volume

54

pub_type

杂志文章
  • Effect of interferon alpha on HLA-DR expression by human buccal epithelial cells.

    abstract::/We have studied the effect of interferon alpha (IFN-alpha) on MHC class II expression by human buccal epithelial cells (BEC), and mRNA expression by BEC and mucosal-associated mononuclear cells (MAMC). In 6 experiments, freshly collected BEC were suspended at a concentration of 1.0 x 10(5)/ml in RPMI 1640 and incubat...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Smith JK,Chi DS,Krishnaswamy G,Srikanth S,Reynolds S,Berk SL

    更新日期:1996-01-01 00:00:00

  • Studies on transferrins of blood serum as selection criteria for animals in breeding herds.

    abstract::In three species of breeding animals: cattle, sheep and pigs the relationship between the polymorphic differentiation of blood serum transferrins and the most important utility traits have been observed. The investigation included 3343 cows of black-white and 1925 cows of red-white breeds, 657 Polish Merino sheep and ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Chudoba K,Jabłońska J,Nowicki B

    更新日期:1981-01-01 00:00:00

  • Implant of polymer containing pentacyclic triterpenes from Eugenia punicifolia inhibits inflammation and activates skeletal muscle remodeling.

    abstract::Sustained chronic inflammation induces activation of genes involved in cellular proliferation and apoptosis, thereby causing skeletal muscle degeneration. To investigate in vitro effects of isolated pentacyclic triterpenes from Eugenia punicifolia (Ep-CM) upon signaling pathways involved in the regulation of skeletal ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:10.1007/s00005-014-0291-0

    authors: Leite PE,Lima-Araújo KG,França GR,Lagrota-Candido J,Santos WC,Quirico-Santos T

    更新日期:2014-12-01 00:00:00

  • P2X7 receptor signaling pathway as a therapeutic target for neurodegenerative diseases.

    abstract::A recent study suggested that neuroinflammation plays a major role in the pathogenesis of a number of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Although the precise mechanism is obscure, dysregulation of the signaling transduction pathway in microglia may enhance inflammation, lea...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-010-0069-y

    authors: Takenouchi T,Sekiyama K,Sekigawa A,Fujita M,Waragai M,Sugama S,Iwamaru Y,Kitani H,Hashimoto M

    更新日期:2010-04-01 00:00:00

  • Fecal Microbiota Transplantation Inhibits Multidrug-Resistant Gut Pathogens: Preliminary Report Performed in an Immunocompromised Host.

    abstract::Colonization of the gastrointestinal tract with multidrug-resistant (MDR) bacteria is a consequence of gut dysbiosis. We describe the successful utilization of fecal microbiota transplantation to inhibit Klebsiella pneumoniae MBL(+) and Escherichia coli ESBL(+) gut colonization in the immunocompromised host as a novel...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 信件

    doi:10.1007/s00005-016-0387-9

    authors: Biliński J,Grzesiowski P,Muszyński J,Wróblewska M,Mądry K,Robak K,Dzieciątkowski T,Wiktor-Jedrzejczak W,Basak GW

    更新日期:2016-06-01 00:00:00

  • How does the major histocompatibility complex influence behavior?

    abstract::The major histocompatibility complex (MHC) encodes highly polymorphic cell surface glycoproteins that form the basis of immunological individuality. It has been postulated that MHC besides its role in immune defence also determines behavior through formation of specific odor cues. In addition several studies have impl...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:

    authors: Janssen E,Zavazava N

    更新日期:1999-01-01 00:00:00

  • Microbial transformation of azacarbazoles. VIII. Production of 14C-labelled benzo-alpha-iso-carbolines by permeabilized cells of Kitasatosporia setae strain.

    abstract::N-1 methylation of benzo-alpha-carbolines performed with Kitasatosporia setae strain yields corresponding benzo-alpha-iso-carbolines, compounds demonstrating relatively strong cytostatic and antitumor properties. To obtain radioactive benzo-alpha-iso-carbolines required for the further studies of their mode of antitum...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Peczyńska-Czoch W

    更新日期:1987-01-01 00:00:00

  • Interleukin 6 and its soluble receptor in periodontitis.

    abstract::The paper presents the evaluation of interleukin 6 (IL-6) and interleukin 6 soluble receptor (sIL-6R) values in the blood serum of patients with various forms of periodontitis (P), as confronted with local state. The study involved a group of 15 patients with P, including 4 patients with rapidly progressive periodonti...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Pietruska M,Pietruski JK,Stokowska W,Jabłońska E

    更新日期:1998-01-01 00:00:00

  • Antiviral signaling through retinoic acid-inducible gene-I-like receptors.

    abstract::The innate immune system is essential for the first line of host defense against micropathogens. In virus-infected cells, exposed viral nucleotides are sensed by pattern recognition receptors (PRRs), resulting in the induction of type I interferon. Retinoic acid-inducible gene-I-like receptors (RLRs) are a member of P...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-010-0107-9

    authors: Matsumiya T,Imaizumi T,Yoshida H,Satoh K

    更新日期:2011-02-01 00:00:00

  • Immunotherapy as an Option for Cancer Treatment.

    abstract::The progress in melanoma immunotherapy highlights the importance of immunotherapy for cancer treatment. Although the concept of immunotherapy emerged in the beginning of the twentieth century, the end of the century signaled the start of modern immunotherapy, which has recently allowed a staggering progress in the fie...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-017-0491-5

    authors: Rusch T,Bayry J,Werner J,Shevchenko I,Bazhin AV

    更新日期:2018-04-01 00:00:00

  • Serologic relationship of fimbriae among Enterobacteriaceae.

    abstract::The existence of serological relationship of fimbriae among serotypes of the same genus and among genera of Enterobacteriaceae was determined by agglutination and absorption procedures. It was found that fimbriae of different serotypes of the same genus and among the genera a) Escherichia, Shigella and Klebsiella, and...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Nowotarska M,Mulczyk M

    更新日期:1977-01-01 00:00:00

  • Is sex worth searching for?

    abstract::Several methods of molecular sexing (i.e. detection of Y-chromosomal sequences) have been briefly presented. In addition to other applications they can be used for monitoring of patients after sex-mismatched bone marrow transplantation for mixed chimerism and for detection of fetal cells in maternal circulation. Clini...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:

    authors: Witt M

    更新日期:1994-01-01 00:00:00

  • Rheumatoid factors bind beta 2 microglobulin. Detection of beta 2 microglobulin-complexes in rheumatoid arthritis.

    abstract::beta 2 Microglobulin binding rheumatoid factors and occurrence of complexed form of beta 2 microglobulin were found in rheumatoid arthritis (RA) by radioimmunological methods. 1. As related to the appropriate values of control sera and osteoarthritic synovial fluids, one of the six sera and five of the six synovial fl...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Falus A,Merétey K,Böhm U,Bozsóky S

    更新日期:1979-01-01 00:00:00

  • The influence of immunosuppressors on rosette forming cells.

    abstract::The influence of antibiotics and purine and pyrimidine analogues on cells forming rosettes EA and EAC was evaluated in vitro. At the same time pH of solutions of examined immunosuppressors was estimated and a series of experiments with a buffer of appropriate pH was carried out. It was estimated that the effect inhibi...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Giełdanowski J

    更新日期:1980-01-01 00:00:00

  • Role of RGS proteins in regulating the migration of B lymphocytes.

    abstract::The migration of B lymphocytes into distinct microenvironments in secondary lymphoid tissues and maintenance of cells in these micro-domains is strictly structured and likely supports the proper regulation of immune responses to both foreign and self-antigens. Chemokines' and other chemoattactants' signals serve as si...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:

    authors: Moratz C,Harrison K,Kehrl JH

    更新日期:2004-01-01 00:00:00

  • Purification of mouse interferon on specifically purified immunoadsorbent.

    abstract::A one-step purification procedure using affinity chromatography on purified anti-interferon antibodies makes possible to obtain highly purified interferon preparations. Antibodies against purified mouse fibroblast interferon were covalently bound to activated CNBr-Sepharose 4B. This immunoadsorbent had a binding capac...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Hajnicka V,Fuchsberger N,Borecký L

    更新日期:1977-01-01 00:00:00

  • Nitrogranulogen-dependent inhibition of antibody synthesis. I. In vitro studies in man.

    abstract::Nitrogranulogen causes a comparable suppression of immunoglobulin synthesis by human lymphocytes in vitro as a standard alkylating agent, 4-hydro-peroxycyclophosphamide. Mixed lymphocyte culture reaction-elicited T and B cell responses are especially sensitive to the agent. The immunosuppressive activity of NTG is enh...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Wasik M,Stepień-Sopniewska B,Kozakiewicz A,Górski A

    更新日期:1991-01-01 00:00:00

  • Validation of basophil CD164 upregulation for pollen allergy diagnosis.

    abstract::The aim of the study was to evaluate the sensitivity and specificity of allergen-induced basophil CD164 upregulation in patients with seasonal allergic rhinitis caused by allergy to grass pollens. This study was performed in 24 patients with allergy to grass pollens, and in 25 healthy controls. The protocol for allerg...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:10.1007/s00005-010-0104-z

    authors: Wolanczyk-Medrala A,Barg W,Liebhart J,Panaszek B,Nadobna G,Litwa M,Gogolewski G,Medrala W

    更新日期:2010-12-01 00:00:00

  • "Publish or Perish" as citation metrics used to analyze scientific output in the humanities: International case studies in economics, geography, social sciences, philosophy, and history.

    abstract::Traditionally, the most commonly used source of bibliometric data is the Thomson ISI Web of Knowledge, in particular the (Social) Science Citation Index and the Journal Citation Reports, which provide the yearly Journal Impact Factors. This database used for the evaluation of researchers is not advantageous in the hum...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:10.1007/s00005-008-0043-0

    authors: Baneyx A

    更新日期:2008-11-01 00:00:00

  • Interferon inhibitors and/or inactivators in sera from patients with neoplasias.

    abstract::Measurements of interferons, their inhibitors and/or inactivators and tumor necrosis factor-like activities in sera from patients with neoplasias were performed. Interferon activity could not be detected in 96% of the sera samples examined. In contrast, both interferon inhibitors and/or inactivators and tumor necrosis...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Tsantakis G,Schizas N,Havredaki M

    更新日期:1993-01-01 00:00:00

  • Murine models of susceptibility to tuberculosis.

    abstract::Approximately one third of the world's population is infected with Mycobacterium tuberculosis,yet each year a small proportion of those individuals progress to an active disease state. Early identification and treatment of such individuals is essential to reduce transmission; however, genetic and immunological correla...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:

    authors: Beamer GL,Turner J

    更新日期:2005-11-01 00:00:00

  • Variant and Specific Forms of Autoimmune Cholestatic Liver Diseases.

    abstract::Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are the main autoimmune cholestatic liver diseases. IgG4-associated sclerosing cholangitis is another distinct immune-mediated cholestatic disorder of unknown aetiology that is frequently associated with autoimmune pancreatitis or other IgG4-re...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-019-00550-9

    authors: Dalekos GN,Gatselis NK

    更新日期:2019-08-01 00:00:00

  • Early changes in the plasma proteins of patients treated with low doses of oral natural human interferon alpha (IFN-alpha).

    abstract::The comparison of electrophoretic protein patterns and concentrations of the G, A and M immunoglobulins before initiation of oral IFN-alpha therapy of viral hepatitis and after 2 weeks of treatment allow to predict patient's response. Patient who after 2 weeks of treatment with ultra-low orally administered IFN-alpha ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Georgiades JA

    更新日期:1993-01-01 00:00:00

  • LL-37 but Not 25-Hydroxy-Vitamin D Serum Level Correlates with Healing of Venous Leg Ulcers.

    abstract::Human cathelicidin, LL-37, is small antimicrobial peptide, which reveals also some immunomodulatory and proangiogenic properties and, therefore, may promote wound healing. The expression of LL-37 is controlled by various factors, including vitamin D. Thus, any disturbances in vitamin D level may influence LL-37 produc...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:10.1007/s00005-016-0423-9

    authors: Krejner A,Litwiniuk M,Grzela T

    更新日期:2017-10-01 00:00:00

  • Effects of interferons, interferon inducers and growth factors on phagocytosis measured by quantitative determination of synthetic compound ingested by mouse bone marrow-derived macrophages.

    abstract::Sodium salt of 9-oxo-10-acridineacetohydroxamic acid (HCA), a new synthetic compound, forms small crystals in aqueous solution. These crystals were easily phagocytized by the mouse bone marrow-derived macrophages. The ingested HCA crystals were visible under light microscope as dark granules. The degree of phagocytosi...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Szulc B,Piasecki E

    更新日期:1988-01-01 00:00:00

  • A trial of using antibodies as carriers of alkylating agents. II. Evaluation of ability to form 32P-cyclophosphamide + immune antibody complexes with homologous antigen.

    abstract::32P-cyclophosphamide was found to combine with gamma-globulin fractions of immune sera. Immune sera incubated with 32P-cyclophosphamide retained ability to react specifically with homologous antigen in vitro in the system: MN antigens of human erythrocytes + rabbit anti-MN antibody, and probably reacted selectively w...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Trzeciak J,Feluś E,Nolewajka E,Szaflarski J,Dudziak Z

    更新日期:1976-01-01 00:00:00

  • The effect of Chlamydia trachomatis infection of the prostate gland on the concentration of citric acid.

    abstract:INTRODUCTION:The objective of the study was to assess the relationship between Chlamydia trachomatis (C.t.) infection of the prostate and the concentration of citric acid. MATERIALS AND METHODS:The study involved 60 patients with chronic prostatitis (NIH III). Urethral swabs and expressed prostatic secretions (EPS) we...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:10.1007/s00005-006-0009-z

    authors: Zdrodowska-Stefanow B,Ostaszewska-Puchalska I,Badyda J,Galewska Z

    更新日期:2006-01-01 00:00:00

  • Prevalence of the intron 22 inversion of the factor VIII gene and inhibitor development in Polish patients with severe hemophilia A.

    abstract:INTRODUCTION:Patients with severe hemophilia A often develop inhibitors (antibodies) against transfused factor VIII. MATERIAL/METHODS:One hundred thirteen Polish patients with severe hemophilia A, who had been treated on demand with cryoprecipitate until 1992 and exclusively with factor VIII concentrates after 1995, w...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Sawecka J,Skulimowska J,Windyga J,Lopaciuk S,Kościelak J

    更新日期:2005-07-01 00:00:00

  • Immune Checkpoint Blockade in Cancer Immunotherapy: Mechanisms, Clinical Outcomes, and Safety Profiles of PD-1/PD-L1 Inhibitors.

    abstract::Programmed cell death protein 1 (PD-1) and its ligand PD-L1 are critical for the regulation of T cell exhaustion and activity suppression. Tumor cells expressing immune checkpoints including PD-L1 escape monitoring of T cells from the host immune system. Checkpoint inhibitors are highly promising therapies that functi...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-020-00601-6

    authors: Yan Y,Zhang L,Zuo Y,Qian H,Liu C

    更新日期:2020-11-13 00:00:00

  • Interconversion between two electrophoretic forms of carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA).

    abstract::CEA and NCA show an increased mobility in SDS-polyacrylamide gel electrophoresis if the samples are preheated in 1% SDS for 5 min at 100 degrees C. Now we found that the slow-to-fast form conversion of CEA and NCA also occurs under milder conditions and is reversible at low SDS concentration. At 100 degrees C the conv...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Krop-Watorek A,Sedlaczek P,Lisowska E

    更新日期:1989-01-01 00:00:00