Cystatin C reference values and aging.


OBJECTIVES:The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging. DESIGN AND METHODS:The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected. RESULTS:CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (<45 years, <0.95 mg/L and >45 years, <1.20 mg/L). CONCLUSIONS:The use of CysC reference values adjusted for age should be carefully taken into consideration.


Clin Biochem


Clinical biochemistry


Ognibene A,Mannucci E,Caldini A,Terreni A,Brogi M,Bardini G,Sposato I,Mosconi V,Salvadori B,Rotella CM,Messeri G




Has Abstract


2006-06-01 00:00:00














  • Reduction of pre-analytical errors in the clinical laboratory at the University Hospital of Korea through quality improvement activities.

    abstract:BACKGROUND:The clinical laboratory is responsible for reporting accurate and expeditious results. However, the pre-analytical phase is directly related to the procedure of specimen collection and is mostly out of the direct control of the laboratory; further, most pre-analytical errors are related to human factors. The...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Lee NY

    更新日期:2019-08-01 00:00:00

  • Use of enzyme immunoassay for measurement of skeletal troponin-I utilizing isoform-specific monoclonal antibodies.

    abstract:OBJECTIVE:To determine the serum level of fast skeletal troponin I (fsTnl) resulting from skeletal muscle damage, we have developed a sensitive two-site enzyme immunoassay to measure skeletal troponin I. DESIGN AND METHODS:Twelve monoclonal antibodies were raised against human fsTnl. Of these antibodies, 8 were fsTnl-...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Takahashi M,Lee L,Shi Q,Gawad Y,Jackowski G

    更新日期:1996-08-01 00:00:00

  • Single-strand conformational polymorphisms (SSCP): studies of the genetic polymorphisms of exon 4 of apolipoprotein C III.

    abstract:OBJECTIVE:We used single-strand conformational polymorphism (SSCP). To screen for mutations/polymorphisms in exon 4 of the apolipoprotein C III in 45 patients with hypertriglyceridemia and 46 control individuals, single-strand conformational polymorphism was investigated using restriction endonuclease and amplification...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Beheshti I,Hanson NQ,Copeland KR,Garg U,Tsai MY

    更新日期:1995-06-01 00:00:00

  • Apolipoprotein E polymorphism in the Tunisian population: frequency and effect on lipid parameters.

    abstract:OBJECTIVES:We determined the frequencies of apolipoprotein E (apo E) gene alleles and examined the association between apo E polymorphism and lipid parameters in a sample of the Tunisian population. DESIGN AND METHODS:Apo E polymorphism was investigated using PCR, and plasma lipid parameters were measured in 122 men a...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Jemaa R,Elasmi M,Naouali C,Feki M,Kallel A,Souissi M,Sanhaji H,Hadj Taïeb S,Souheil O,Kaabachi N

    更新日期:2006-08-01 00:00:00

  • Tamm-Horsfall protein excretion to predict the onset of renal insufficiency.

    abstract:OBJECTIVE:Immunosuppressive therapy after liver transplantation may be a risk for kidney dysfunction. This work was designed to determine whether Tamm-Horsfall Protein (THP) could be considered as a marker for nephrotoxicity. DESIGN AND METHODS:THP was determined by an ELISA method in serial 24-h urine from liver tran...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Romero MC,Zanaro N,González L,Trigo P,Imventarza O,Nesse A

    更新日期:2002-02-01 00:00:00

  • Biochemical and biological aspects of the plasminogen activation system.

    abstract::Plasminogen activators (PAs) are specific proteolytic enzymes which convert the inactive proenzyme plasminogen to plasmin. The plasmin formed is a potent and nonspecific protease which cleaves blood fibrin clots and several other extracellular proteins. In addition to their primary role in the initiation of fibrinolys...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Mayer M

    更新日期:1990-06-01 00:00:00

  • Serum iron determination using ferene triazine.

    abstract::The synthesis and characterisation of a new colorimetric reagent for iron, 3-(2-pyridyl)-5,6-bis(2-furyl)-1,2,4-triazine are described. Peak assignments and chemical shifts of the high resolution 13C nmr spectrum are given. The reagent forms a tris iron(II) complex with epsilon max of 32000 Lcm-1 mol-1 at 577 nm. The ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Smith FE,Herbert J,Gaudin J,Hennessy DJ,Reid GR

    更新日期:1984-10-01 00:00:00

  • Combinative analysis of factors influence serum alanine aminotransferase activity in adult male population from southern China.

    abstract:OBJECTIVES:Abnormal alanine aminotransferase (ALT) activity is indicative of liver disease even a burden of overall health. We assessed the factors associated with ALT activity and their internal relationships in a male population from southern China. DESIGN AND METHODS:Data of physical examinations, laboratory tests,...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Liu Z,Hu Y,Yang X,Tan A,Gao Y,Qin X,Liang Y,Mo Z,Peng T

    更新日期:2012-12-01 00:00:00

  • Characterization and mRNA expression analysis of a novel ARG1 splicing mutation causing hyperargininemia.

    abstract:OBJECTIVES:Biallelic mutations in the ARG1 gene result in an uncommon autosomal recessive inborn defect of the urea cycle known as hyperargininemia (OMIM #207800). ARG1 splicing mutations are not reported often, and they are probably related to a more severe phenotype than missense mutations. In this article, we descri...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Villegas-Ruiz V,Campos-Garcia FJ,Contreras-Capetillo S,Moreno-Graciano CM,Maldonado-Solis FA,Maldonado-Solis MA,Zenteno JC

    更新日期:2015-12-01 00:00:00

  • Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure.

    abstract:OBJECTIVES:To evaluate platelet activating factor (PAF) levels, its metabolic enzymes activity and its associations with other inflammatory markers in heart failure (HF) patients. DESIGN AND METHODS:PAF, and two of its key biosynthetic enzymes [lyso-PAF acetyltransferase (lyso-PAF-AT) and DTT-insensitive CDP-choline:1...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Detopoulou P,Nomikos T,Fragopoulou E,Antonopoulou S,Kotroyiannis I,Vassiliadou C,Panagiotakos DB,Chrysohoou C,Pitsavos C,Stefanadis C

    更新日期:2009-01-01 00:00:00

  • Effect of renal function on serum cardiac troponin T--Population and individual effects.

    abstract:BACKGROUND:Elevations of serum cardiac troponin T (cTnT) have been described in patients with end stage chronic kidney disease (CKD) although the mechanism is unknown, whether from increased production or decreased clearance. Less is known about cTnT in short term changes in renal function and in lesser degrees of rena...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Chung JZ,Dallas Jones GR

    更新日期:2015-08-01 00:00:00

  • Development of an immunoassay for differentiating human immunodeficiency virus infections--from vaccine-induced immune response in Tiantan vaccine trials in China.

    abstract:OBJECTIVE:To develop a Rapid Flow-through assay for distinguishing replicating Tiantan vaccine-generated serological response from true HIV infection. DESIGN AND METHOD:A Rapid Flow-through Test including gp41, gp36, sk1, sk2 and sk3 antigens was established and the performance of the assay was evaluated in clinical s...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Yuan Z,Chen W,Zhang J,Zhang J,Xiang T,Hu J,Wu Z,Du X,Huang A,Zheng J

    更新日期:2012-10-01 00:00:00

  • Human bone cells contain a fluoride sensitive acid phosphatase: evidence that this enzyme functions at neutral pH as a phosphotyrosyl protein phosphatase.

    abstract::Fluoride is a potent therapeutic agent that increases spinal bone density in osteoporotic subjects. Based on work with animal cells previously, we proposed fluoride acts by inhibiting phosphotyrosyl protein phosphatase (EC activity in bone cells. The presence of fluoride sensitive acid phosphatase (EC 3.1.3....

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Wergedal JE,Lau KH

    更新日期:1992-02-01 00:00:00

  • A survey to identify potential outcome indicators for a hospital blood glucose monitoring program.

    abstract:OBJECTIVE:A survey of operators of a bedside blood glucose monitoring (BGM) program at a tertiary health care institution was performed to identify potential outcome indicators for our quality assurance program. DESIGN AND METHODS:170 surveys were randomly distributed to each nursing unit. The survey consisted of 20 q...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Collier CP,Houlden RL,Gleeson KA,Patrzykat A,Rhymer SL

    更新日期:1998-06-01 00:00:00

  • Comparison of precision for the Kodak Ektachem 400 and Technicon AutoAnalyzer II creatinine methods.

    abstract::We have evaluated the precision of the Ektachem 400 thin film enzymic creatinine method and compared it to that obtained for an AutoAnalyzer II (AAII) picric acid procedure. The results of the study show that the Ektachem method yields imprecise creatinine values over the low concentration range (40-240 mumol/L). Run-...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Jacklyn CL,Matte SJ,Ryder DI,Cousins CL,Moss MA

    更新日期:1985-12-01 00:00:00

  • Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain.

    abstract:OBJECTIVES:Concentrations of troponin measured with high sensitivity troponin assays are raised in a number of emergency department (ED) patients; however many are not diagnosed with acute myocardial infarction (AMI). Clinical comparisons between the early use (2h after presentation) of high sensitivity cardiac troponi...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Cullen L,Aldous S,Than M,Greenslade JH,Tate JR,George PM,Hammett CJ,Richards AM,Ungerer JP,Troughton RW,Brown AF,Flaws DF,Lamanna A,Pemberton CJ,Florkowski C,Pretorius CJ,Chu K,Parsonage WA

    更新日期:2014-04-01 00:00:00

  • Comparison by LC-MS and MALDI-MS of prostate-specific antigen from five commercial sources with certified reference material 613.

    abstract:OBJECTIVE:Prostate-specific antigen (PSA) samples from five commercial sources were compared with PSA from the European Commission Community Bureau of Reference, known as CRM 613, using liquid chromatography-mass spectrometry (LC-MS) and matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS). DESIGN ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Satterfield MB,Welch MJ

    更新日期:2005-02-01 00:00:00

  • Study of serum antioxidant capacity and relation with CA 19-9 and PSA in patients with gastrointestinal tract and prostate tumors.

    abstract:OBJECTIVES:We undertook the present study to investigate the possible relation between total antioxidant capacity (TAC) and tumor marker (TM) values in serum samples of patients with and without gastrointestinal tract and prostate tumors. DESIGN AND METHODS:We measured the TAC using trolox equivalent antioxidant capac...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: López Vélez M,Martínez Martínez F

    更新日期:2011-09-01 00:00:00

  • Low basal levels of circulating adiponectin in patients undergoing coronary stenting predict in-stent restenosis, independently of basal levels of inflammatory markers: lipoprotein associated phospholipase A2, and myeloperoxidase.

    abstract:OBJECTIVE:The aim of this study was to find a pre-interventional marker with the capacity to predict in-stent restenosis (ISR). Considering the anti-atherosclerotic role of adiponectin (APO), an adipocytokine with anti-inflammatory, anti-proliferative, anti-oxidative and anti-thrombotic properties, low plasma levels of...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Moldoveanu E,Mut-Vitcu B,Tanaseanu GR,Marta DS,Manea G,Kosaka T,Vidulescu C,Tanaseanu C

    更新日期:2008-12-01 00:00:00

  • Osteoprotegerin (OPG) and TNF-related apoptosis-inducing ligand (TRAIL) levels in malignant and benign pericardial effusions.

    abstract:OBJECTIVES:Osteoprotegerin (OPG) is a regulator of bone and vascular homeostasis and acts as a decoy receptor for proapoptotic TNF-related apoptosis-inducing ligand (TRAIL). DESIGN AND METHODS:We assessed pericardial and serum levels of OPG and TRAIL in pericardial effusions (PE) of malignant (mPE, n=24) or non-malign...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Karatolios K,Pankuweit S,Goettsch C,Hofbauer LC,Timmesfeld N,Al-Fakhri N,Maisch B,Schoppet M

    更新日期:2012-02-01 00:00:00

  • Biochemical impact of a soccer match - analysis of oxidative stress and muscle damage markers throughout recovery.

    abstract:BACKGROUND:Exercise is a prone condition to enhanced oxidative stress and damage and the specific activity pattern of a soccer match may favour additional pro-oxidant redox alterations. To date, no studies have reported the impact of a soccer match on oxidative stress and muscle damage markers. AIM:To analyse the effe...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Ascensão A,Rebelo A,Oliveira E,Marques F,Pereira L,Magalhães J

    更新日期:2008-07-01 00:00:00

  • Cyclosporine nephrotoxicity--experimental models.

    abstract::Cyclosporine A (CsA) represents one of the more important therapeutic advances in the field of kidney transplantation. However, its effectiveness is limited by serious side effects, most notably nephrotoxicity. Investigation of the mechanisms of CsA-induced renal dysfunction has been hampered by the lack of a suitable...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Thliveris JA,Yatscoff RW,Lukowski MP,Copeland KR

    更新日期:1991-02-01 00:00:00

  • Steroid profiles in both blood serum and seminal plasma are not correlated and do not reflect sperm quality: Study on the male reproductive health of fifty young Swiss men.

    abstract::Steroids play an important role in sperm production and quality. These hormones have been extensively studied in blood, but poorly investigated in semen. The purpose of our study was to evaluate the relationship between sperm quality and steroid profiles in blood and semen in a small cohort of young Swiss men. Another...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Zufferey F,Rahban R,Garcia A,Gagnebin Y,Boccard J,Tonoli D,Jeanneret F,Stettler E,Senn A,Nef S,Rudaz S,Rossier MF

    更新日期:2018-12-01 00:00:00

  • Slow beta-migrating lipoprotein: an atherogenic subclass of low density lipoproteins.

    abstract:OBJECTIVE:To clarify the possibility that midband Lp in LDL fractions might act as an atherogenic lipoprotein in their interaction with macrophages. DESIGN AND METHODS:Low density lipoproteins (LDL) isolated by zonal ultracentrifugation from midband lipoprotein-positive serum in type lib hyperlipidemics were subjected...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Kawano M,Shinomiya M,Kanzaki T,Morisaki N,Shirai K,Saito Y,Yoshida S

    更新日期:1996-06-01 00:00:00

  • Plasma arginase concentration measured by an enzyme-linked immunosorbent assay (ELISA) in normal adult population.

    abstract::Human liver arginase has many biological effects on lymphocytes, macrophages, liver cells, and tumor cells, in addition to its major role in the liver urea cycle. We have developed a sandwich enzyme-linked immunosorbent assay (ELISA) method to quantitate arginase concentrations in plasma that can be applied to various...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Wang SR,Chen ML,Huang MH,Lin HY,Tsai JJ,Kuo BI

    更新日期:1993-12-01 00:00:00

  • A luciferase immunoprecipitation assay for the detection of proinsulin/insulin autoantibodies.

    abstract:AIM:Luciferase immunoprecipitation (LIPS) assays show good sensitivity and specificity in testing islet specific autoantibodies for diagnosis of type 1 diabetes (T1D). However, there are currently no LIPS assays available for detecting proinsulin/insulin autoantibody (IAA) previously. We here developed a LIPS assay to ...

    journal_title:Clinical biochemistry

    pub_type: 临床试验,杂志文章


    authors: Ling Y,Jiang P,Li N,Yan Q,Wang X

    更新日期:2018-04-01 00:00:00

  • Increased glutathionylated hemoglobin (HbSSG) in type 2 diabetes subjects with microangiopathy.

    abstract:OBJECTIVE:Protein glutathionylation is considered an important post-translational modification in the pathogenesis of complex diseases. The aim of this study was to examine whether hemoglobin (Hb) is modified by reduced glutathione (GSH) via oxidation of the thiol groups present in diabetes and its associated microangi...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Sampathkumar R,Balasubramanyam M,Sudarslal S,Rema M,Mohan V,Balaram P

    更新日期:2005-10-01 00:00:00

  • Magnesium status and excretion in age-matched subjects with normal and elevated blood pressures.

    abstract::Plasma, erythrocyte, and leucocyte magnesium (Mg) concentration, as well as urinary Mg, calcium (Ca), and phosphorus (P) excretion were determined in male subjects with elevated diastolic blood pressure (DBP) > 90 mmHg. These parameters were compared to those in normotensive age-matched (DBP < 85 mmHg) and drug-treate...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Fischer PW,Belonje B,Giroux A

    更新日期:1993-06-01 00:00:00

  • Disinfectant wipes containing hydrogen peroxide induce overestimation of glucose results obtained with Lifescan SureStep Flexx® glucose meter.

    abstract:OBJECTIVES:Investigate the interference of Virox® disinfectant wipes containing hydrogen peroxide with Lifescan SureStep Flexx® glucose meter results. DESIGN AND METHODS:Glucose measurements of control and whole blood samples were performed before and after cleaning with Virox® wipes to reveal the kinetics of this int...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Desmeules P,Ethier J,Allard P

    更新日期:2010-12-01 00:00:00

  • The measurement of serum cholinesterase activities by an integration strategy with expanded linear ranges and negligible substrate-activation.

    abstract:OBJECTIVES:To measure serum cholinesterase (SCHE) with an integration strategy. DESIGN AND METHODS:At 54.0 micromol/L butyrylthiolcholine, SCHE initial rates were calculated with 50.0 micromol/L butyrylthiolcholine and maximal rates via an improved integrated method if substrate consumptions within 5.0 min were over 6...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Liao F,Yang D,Tang J,Yang X,Liu B,Zhao Y,Zhao L,Liao H,Yu M

    更新日期:2009-06-01 00:00:00