Cystatin C reference values and aging.


OBJECTIVES:The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging. DESIGN AND METHODS:The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected. RESULTS:CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (<45 years, <0.95 mg/L and >45 years, <1.20 mg/L). CONCLUSIONS:The use of CysC reference values adjusted for age should be carefully taken into consideration.


Clin Biochem


Clinical biochemistry


Ognibene A,Mannucci E,Caldini A,Terreni A,Brogi M,Bardini G,Sposato I,Mosconi V,Salvadori B,Rotella CM,Messeri G




Has Abstract


2006-06-01 00:00:00














  • Sample application position and the resolution of protein separation on the Beckman Microzone Electrophoretic System.

    abstract::Many clinical laboratories use the Beckman Microzone electrophoretic system (Beckman Instruments Inc. Fullerton, CA 92634) for serum protein separation. Although detailed instruction is supplied in the manufacturer's manual (1) for protein separation, the effect of different sample application positions on the cellulo...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Chu SY,Turkington VE

    更新日期:1978-12-01 00:00:00

  • Association between positive fecal occult blood test and diabetes in a population undergoing health screening.

    abstract:BACKGROUND:Numerous etiologies are implicated in the complications of diabetes. A link between diabetes and the predisposition to certain cancers, including colon cancer, has been established during the last decade. However, the relationship between fecal occult blood test (FOBT), a screening method used principally fo...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Nakajima K,Suwa K

    更新日期:2017-01-01 00:00:00

  • Plasma visfatin and retinol binding protein-4 levels in patients with type 2 diabetes mellitus and their relationship to adiposity and fatty liver.

    abstract:OBJECTIVES:We investigated whether plasma visfatin and binding protein-4 (RBP-4) levels correlate with obesity and type 2 diabetes mellitus (T2DM). DESIGN AND METHODS:Two groups were enrolled: Group 1: 40 patients with T2DM and Group 2: 40 age- and gender-matched healthy controls. Both groups were subdivided according...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Shaker O,El-Shehaby A,Zakaria A,Mostafa N,Talaat S,Katsiki N,Mikhailidis DP

    更新日期:2011-12-01 00:00:00

  • Polymorphisms in the long non-coding RNA CDKN2B-AS1 may contribute to higher systolic blood pressure levels in hypertensive patients.

    abstract:OBJECTIVES:Hypertension (HT) is a complex disorder influenced by both genetic and environmental factors. Recent genome-wide association studies have identified a major risk locus for atherosclerosis on chromosome 9p21.3. SNPs within the coding sequences of CDKN2A/B and the long non-coding RNA CDKN2B-AS1 could potential...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Bayoglu B,Yuksel H,Cakmak HA,Dirican A,Cengiz M

    更新日期:2016-07-01 00:00:00

  • Urinary matrix metalloproteinase-8 and -9 activities in type 2 diabetic subjects: A marker of incipient diabetic nephropathy?

    abstract::Matrix metalloproteinases (MMPs) may play a pathophysiological role in the development of diabetic nephropathy (DN). We hypothesized that urinary MMP activity in patients with type 2 diabetes mellitus (T2DM) is related to a decline in renal function. We determined MMP-2, -8 and -9 activity in 24-h urine collections in...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: van der Zijl NJ,Hanemaaijer R,Tushuizen ME,Schindhelm RK,Boerop J,Rustemeijer C,Bilo HJ,Verheijen JH,Diamant M

    更新日期:2010-05-01 00:00:00

  • Batch to batch imprecision in the affinity chromatography assay of glycated hemoglobin.

    abstract::An affinity chromatographic method (AC) was compared with ion exchange chromatography (IEC) for determination of glycated hemoglobin (gHb). In vitro, increasing glucose concentration produced no change on AC-determined gHb. gHb measurement by AC was highly correlated with mean blood glucose (r = 0.96). Mean values of ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Wettre S,von Schenck H

    更新日期:1986-12-01 00:00:00

  • Quantification of the variation due to lysing technique in immunophenotyping of healthy and HIV-infected individuals.

    abstract:OBJECTIVE:We performed a side-by-side comparison between three stain-then-lyse commercially available methods (Ortho-mune Lysing solution, FACS lysing solution and ImmunoPrep reagent system) and a lyse-then-stain method using hypotonic NH4Cl. The major difference between these methods is that only in the latter the ali...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Pacifici R,Zuccaro P,Cozzi-Lepre A,di Carlo S,Bacosi A,Fattorossi A

    更新日期:1998-04-01 00:00:00

  • Val-9Ala and Ile+58Thr polymorphism of MnSOD in Parkinson's disease.

    abstract:OBJECTIVES:To investigate the polymorphism distribution of Val-9Ala and Ile+58Thr of the Mn-superoxide dismutase (Mn-SOD) gene among subjects with Parkinson's disease (PD) by analyses of genders and clinical severity. DESIGN AND METHODS:We examined the DNA genotypes of Val-9Ala and Ile+58Thr from 295 PD subjects and 1...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Wang V,Chen SY,Chuang TC,Shan DE,Soong BW,Kao MC

    更新日期:2010-08-01 00:00:00

  • Long-term stability of biochemical markers in pediatric serum specimens stored at -80 °C: a CALIPER Substudy.

    abstract:OBJECTIVES:Pediatric serum samples collected from healthy children in the CALIPER (Canadian Laboratory Initiative in Pediatric Reference Interval) project are stored at -80 °C for various periods of time. This study aimed to determine the stability of chemistry, protein, and hormone analytes under these conditions. DE...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Brinc D,Chan MK,Venner AA,Pasic MD,Colantonio D,Kyriakopolou L,Adeli K

    更新日期:2012-07-01 00:00:00

  • Measurement of cystine in granulocytes using liquid chromatography-tandem mass spectrometry.

    abstract:BACKGROUND:Cystinosis is a rare autosomal recessive disorder characterized by an accumulation of intralysosomal cystine due to a defect in cystine transport across the lysosomal membrane. This disorder can be treated specifically using high doses of cysteamine. Accurate measurement of intracellular cystine content is n...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Chabli A,Aupetit J,Raehm M,Ricquier D,Chadefaux-Vekemans B

    更新日期:2007-06-01 00:00:00

  • Low basal levels of circulating adiponectin in patients undergoing coronary stenting predict in-stent restenosis, independently of basal levels of inflammatory markers: lipoprotein associated phospholipase A2, and myeloperoxidase.

    abstract:OBJECTIVE:The aim of this study was to find a pre-interventional marker with the capacity to predict in-stent restenosis (ISR). Considering the anti-atherosclerotic role of adiponectin (APO), an adipocytokine with anti-inflammatory, anti-proliferative, anti-oxidative and anti-thrombotic properties, low plasma levels of...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Moldoveanu E,Mut-Vitcu B,Tanaseanu GR,Marta DS,Manea G,Kosaka T,Vidulescu C,Tanaseanu C

    更新日期:2008-12-01 00:00:00

  • The biosynthesis of prostate-specific antigen in non prostatic cell lines.

    abstract::The biosynthesis of prostate specific antigen (PSA) was studied in human epidermoid carcinoma, (KB) cells and in normal human embryonic lung (WI-38)cells. The prostate carcinoma cell line, PC-35F12 was used as a control. PSA specific antibodies were used to precipitate the immunologically reactive peptides from cell e...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Waheed A,Van Etten RL

    更新日期:2001-11-01 00:00:00

  • Tamm-Horsfall protein excretion to predict the onset of renal insufficiency.

    abstract:OBJECTIVE:Immunosuppressive therapy after liver transplantation may be a risk for kidney dysfunction. This work was designed to determine whether Tamm-Horsfall Protein (THP) could be considered as a marker for nephrotoxicity. DESIGN AND METHODS:THP was determined by an ELISA method in serial 24-h urine from liver tran...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Romero MC,Zanaro N,González L,Trigo P,Imventarza O,Nesse A

    更新日期:2002-02-01 00:00:00

  • Quality assessment of microarray experiments.

    abstract:OBJECTIVES:We describe a quality assurance procedure to maximize the value of oligonucleotide microarray expression profiles. DESIGN, METHODS, AND RESULTS:Background microarray noise was 82.2+/-54.5 and 51.8+/-12.4 units, respectively, before and after enacting the program (P<0.0001). We also noted improved concordanc...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Carter DE,Robinson JF,Allister EM,Huff MW,Hegele RA

    更新日期:2005-07-01 00:00:00

  • Comparison of mycophenolic acid concentrations determined by a new PETINIA assay on the dimension EXL analyzer and a HPLC-UV method.

    abstract:OBJECTIVE:Mycophenolic acid requires routine therapeutic drug monitoring. We evaluated the suitability of a new PETINIA (particle enhanced turbidimetric inhibition immunoassay) assay on the Dimension EXL analyzer for monitoring of mycophenolic acid by comparing values obtained by this assay with a HPLC-UV method. DESI...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Dasgupta A,Tso G,Chow L

    更新日期:2013-05-01 00:00:00

  • Comparison of new solid-phase extraction methods for chromatographic identification of drugs in clinical toxicological analysis.

    abstract:OBJECTIVES:Newly presented solid-phase extraction methods (Solid Phase Disc Extraction, SPEC-Plus, Multi-Modal, and Solid Phase Micro Extraction, SPME have been checked with respect to their applicability to clinical toxicological analysis. In comparison with conventional liquid/liquid-extraction and a common mixed-pha...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Degel F

    更新日期:1996-12-01 00:00:00

  • Plasma advanced glycation endproduct, methylglyoxal-derived hydroimidazolone is elevated in young, complication-free patients with Type 1 diabetes.

    abstract:OBJECTIVES:Elevated advanced glycation endproducts (AGEs) are implicated in diabetic complications. Methylglyoxal-derived hydroimidazolone (MG-H) is one of the most abundant AGEs in vivo. Our objective was to develop a time-saving, specific method to measure free MG-H in plasma and determine its levels in complication-...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Han Y,Randell E,Vasdev S,Gill V,Curran M,Newhook LA,Grant M,Hagerty D,Schneider C

    更新日期:2009-05-01 00:00:00

  • 1,5-anhydroglucitol monitoring in diabetes: a mass balance perspective.

    abstract::1,5-anhydroglucitol (AG) is a nonmetabolizable glucose analogue found in plasma due to ingestion. The normal steady-state concentration can be dramatically decreased by inhibition of tubular reabsorption during periods of hyperglycemia. For this reason, monitoring of AG has been plausibly advocated for detection of pe...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Nerby CL,Stickle DF

    更新日期:2009-02-01 00:00:00

  • Influence of temperature and period of freezing on the generation of hemolysate and blood cell lysate.

    abstract:BACKGROUND:There is little information on temperature and period of freezing for generating hemolysate and blood cell lysate. MATERIALS AND METHODS:Primary tubes containing whole blood were frozen at -20°C and -80°C and then serially thawed to assess cell lysis and clinical chemistry tests in centrifuged plasma. RESU...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Lippi G,Musa R,Aloe R,Mercadanti M,Pipitone S

    更新日期:2011-10-01 00:00:00

  • Mass spectrometric quantification of salivary metanephrines-A study in healthy subjects.

    abstract:BACKGROUND:Determination of metanephrine (MN), normetanephrine (NMN), and 3-methoxytyramine (3-MT) in saliva may offer potential diagnostic advantages in diagnosing pheochromocytoma. METHODS:In this preliminary study, we determined metanephrine concentrations in saliva of healthy subjects and the relationship with sim...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Osinga TE,van der Horst-Schrivers AN,van Faassen M,Kerstens MN,Dullaart RP,Pacak K,Links TP,Kema IP

    更新日期:2016-09-01 00:00:00

  • The changes of trace elements, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia.

    abstract:OBJECTIVES:Increased free radical activity and lipid peroxidation may be implicated in the pathogenesis of preeclampsia. This study was initiated to assess antioxidant enzyme and trace metals's status in preeclampsia. DESIGN AND METHODS:The comparison was made between the pregnant women with or without preeclampsia an...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Ilhan N,Ilhan N,Simsek M

    更新日期:2002-07-01 00:00:00

  • Glucose-6-phosphate dehydrogenase enzyme stability in filter paper dried blood spots.

    abstract:OBJECTIVE:Prior to initial distribution of Glucose-6-phosphate dehydrogenase (G6PD) proficiency testing (PT) materials, we evaluated G6PD enzyme stability in dried blood spots (DBS) under various temperature and humidity environments to develop storage and usage guidelines for our new materials. DESIGN & METHODS:We pr...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Flores SR,Hall EM,De Jesús VR

    更新日期:2017-10-01 00:00:00

  • Effect of repeated freeze-thaw cycles on maternal serum biological markers for the detection of fetal trisomies.

    abstract:OBJECTIVES:We studied the stability of maternal blood markers for screening for Down syndrome (alpha-fetoprotein, unconjugated estriol, intact human chorionic gonadotropin (hCG) and free beta-human chorionic gonadotropin) upon repeated freeze-thaw cycles. DESIGN AND METHODS:Forty-three samples collected from second tr...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Massé J,Forest JC,Moutquin JM,Degrandpre P

    更新日期:1997-10-01 00:00:00

  • Elevated hemoglobin A1 in streptozotocin diabetic rats and in rats on sucrose and galactose-enriched diets.

    abstract::Increased hemoglobin A1 (HbA1) occurs in diabetes mellitus as a direct consequence of hyperglycemia, which causes postsynthetic modification of hemoglobin proportional to blood glucose concentration. Glycosylation of hemoglobin is demonstrable also in vitro, not only by glucose, but with other reducing sugars such as ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Powell HC,Ivor LP,Costello ML,Wolf PL

    更新日期:1982-06-01 00:00:00

  • Effect of dehydroepiandrosterone (DHEA) treatment on oxidative energy metabolism in rat liver and brain mitochondria. A dose-response study.

    abstract:OBJECTIVES:Effects of treatment with dehydroepiandrosterone (DHEA) on oxidative energy metabolism in rat liver and brain mitochondria were examined. DESIGN AND METHODS:Young adult rats were administered DHEA (0.1, 0.2, 1.0 or 2.0 mg/kg body weight) by subcutaneous route for 7 consecutive days. RESULTS:DHEA treatment ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Patel MA,Katyare SS

    更新日期:2007-01-01 00:00:00

  • Direct circulating tumor DNA detection from unpurified plasma using a digital PCR platform.

    abstract:BACKGROUND:In standard pre-analytical conditions, an isolation step is required for circulating tumor DNA (ctDNA) analysis. The need for this step remains unclear with the development of ultrasensitive detection technologies such as digital PCR (dPCR). The aim of our study was to evaluate the ctDNA detection by dPCR pl...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Sefrioui D,Beaussire L,Perdrix A,Clatot F,Michel P,Frebourg T,Di Fiore F,Sarafan-Vasseur N

    更新日期:2017-11-01 00:00:00

  • Enzymatic imbalance in peripheral blood mononuclear cells isolated from individuals with anti-HIV antibodies.

    abstract::Plasma membrane-bound 5'-nucleotidase (5'-NT), gamma-glutamyltransferase (gamma-GT) and soluble deoxynucleotidyltransferase (TdT) were studied in peripheral blood cells (PBMN) of 35 individuals, 26 male and 9 female, with circulating anti-HIV antibodies. Twenty-six were drug abusers, 2 were drug abusers and homosexual...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Losa GA

    更新日期:1989-08-01 00:00:00

  • Evaluation of hemoglobin interference in capillary heel-stick samples collected for determination of neonatal bilirubin.

    abstract:OBJECTIVE:In this study, we determined the assay performance criteria necessary to produce acceptable results for >or=98% of neonate bilirubin samples collected by capillary heel-stick. STUDY DESIGN AND METHODS:We determined serum free hemoglobin levels in 151 heel-stick serum samples to determine the hemolysis level....

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Algeciras-Schimnich A,Cook WJ,Milz TC,Saenger AK,Karon BS

    更新日期:2007-11-01 00:00:00

  • Maternal plasma RNA sequencing.

    abstract::This review discusses the question: which steps are essential or need to be optimized so that maternal plasma RNA sequencing for pre-eclampsia and related syndromes will become as specific and sensitive as maternal plasma DNA sequencing for trisomy? ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Oudejans CB

    更新日期:2015-10-01 00:00:00

  • Increased glutathionylated hemoglobin (HbSSG) in type 2 diabetes subjects with microangiopathy.

    abstract:OBJECTIVE:Protein glutathionylation is considered an important post-translational modification in the pathogenesis of complex diseases. The aim of this study was to examine whether hemoglobin (Hb) is modified by reduced glutathione (GSH) via oxidation of the thiol groups present in diabetes and its associated microangi...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Sampathkumar R,Balasubramanyam M,Sudarslal S,Rema M,Mohan V,Balaram P

    更新日期:2005-10-01 00:00:00