Cystatin C reference values and aging.

Abstract:

OBJECTIVES:The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging. DESIGN AND METHODS:The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected. RESULTS:CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (<45 years, <0.95 mg/L and >45 years, <1.20 mg/L). CONCLUSIONS:The use of CysC reference values adjusted for age should be carefully taken into consideration.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Ognibene A,Mannucci E,Caldini A,Terreni A,Brogi M,Bardini G,Sposato I,Mosconi V,Salvadori B,Rotella CM,Messeri G

doi

10.1016/j.clinbiochem.2006.03.017

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

658-61

issue

6

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(06)00139-1

journal_volume

39

pub_type

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