Socio-demographic factors in the prognosis of oral cancer patients.


:The aim of this study was to determine the survival rate of oral cancer patients treated in a medical center in central Taiwan and to investigate whether socio-demographic factors influence their survival. We retrospectively reviewed 1010 chart records of oral cancer patients. Survival was analyzed by the Kaplan-Meier method and Cox proportional hazard model was used for investigating the relationship between socio-demographic factors and survival. The overall 5-year survival rate was 63.24%. Multivariate analysis revealed that those without religious belief tended to have higher probability of death than those who had religious belief (relative risk (RR): 2.057, p<0.001). In addition, those who were single, widow/widower or divorced/separated had a poorer prognosis than those who were married (RR: 1.528, p=0.008). Apart from clinical features, socio-demographic factors also significantly influenced the survival of oral cancer patients. Therefore, care providers should take socio-demographic issues into consideration aside from ordinary clinical health care.


Oral Oncol


Oral oncology


Wong YK,Tsai WC,Lin JC,Poon CK,Chao SY,Hsiao YL,Chan MY,Cheng CS,Wang CC,Wang CP,Liu SA




Has Abstract


2006-10-01 00:00:00














  • Cost-effectiveness analysis of the oral cancer screening program in Taiwan.

    abstract:OBJECTIVES:We assess the incremental cost-effectiveness ratio (ICER) of the oral cancer (OC) screening program in Taiwan. MATERIALS AND METHODS:We interlinked the Cancer Registry, Mortality Registry, National Vital Statistics, reimbursement database of National Health Insurance, and the National Oral Cancer Screening ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Huang CC,Lin CN,Chung CH,Hwang JS,Tsai ST,Wang JD

    更新日期:2019-02-01 00:00:00

  • Multiple primary tumours in patients with oral squamous cell carcinoma.

    abstract::A series of patients with oral squamous cell carcinoma (SCC) observed at the "Regina Elena" Cancer Institute was retrospectively reviewed in order to analyse the risk factors for multiple and second primary tumours (SPTs), their impact on survival and effective measures to control this phenomenon. In a survey of 200 i...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Cianfriglia F,Di Gregorio DA,Manieri A

    更新日期:1999-03-01 00:00:00

  • Association between oral leukoplakia and upper gastrointestinal cancers: a 28-year follow-up study in the Linxian General Population Trial.

    abstract:BACKGROUND:Oral leukoplakia is a precancerous disorder that is common among residents in Linxian. However, the associations between oral leukoplakia and upper gastrointestinal cancers have not been reported. We investigated the relationships between oral leukoplakia and upper gastrointestinal cancers in the Linxian Gen...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Fan JH,Wang JB,Qu CX,Zhang YQ,Taylor PR,Abnet CC,Dawsey SM,Qiao YL

    更新日期:2014-10-01 00:00:00

  • Oropharyngeal carcinoma in non-smokers and non-drinkers: a role for HPV.

    abstract::Incidence of oropharyngeal squamous cell carcinoma (OSCC) increased 3% annually from 1973 to 2001. OSCC's can be attributed to tobacco and alcohol, but 25% are unlinked to typical risks. Case-control studies on HPV detection in non-smoking/non-drinking (NS/ND) OSCC patients have not previously been performed. The prim...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Andrews E,Seaman WT,Webster-Cyriaque J

    更新日期:2009-06-01 00:00:00

  • The lip-splitting mandibulotomy: aesthetic and functional outcomes.

    abstract::To determine the aesthetic and functional outcomes of the most invasive approach to oral cavity/oropharyngeal lesions, the lip-splitting mandibulotomy approach (LSMA), versus the least invasive, the trans-oral approach (TOA). Retrospective paired-cohort study. Thirty-six patients with oral/oropharyngeal cancers treate...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Dziegielewski PT,O'Connell DA,Rieger J,Harris JR,Seikaly H

    更新日期:2010-08-01 00:00:00

  • Combined effects of MDM2 SNP 309 and p53 mutation on oral squamous cell carcinomas associated with areca quid chewing.

    abstract::The recently identified single nucleotide polymorphism in the MDM2 promoter (SNP 309) may contribute to the early onset of both sporadic and hereditary malignancies in patients with defective p53. We tested this hypothesis by examining the effects of combined MDM2 polymorphisms and somatic p53 mutations on 351 oral sq...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Huang SF,Chen IH,Liao CT,Wang HM,Liou SH,Hsieh LL

    更新日期:2009-01-01 00:00:00

  • Recurrent FGFR1 amplification and high FGFR1 protein expression in oral squamous cell carcinoma (OSCC).

    abstract::Chromosomal aberrations are known to have an impact on the initiation and progression of oral squamous cell carcinoma (OSCC), but individual genes involved in OSCC pathogenesis are poorly described. To elucidate the molecular events underlying oral carcinogenesis, a set of primary OSCC were screened for distinct genet...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Freier K,Schwaenen C,Sticht C,Flechtenmacher C,Mühling J,Hofele C,Radlwimmer B,Lichter P,Joos S

    更新日期:2007-01-01 00:00:00

  • Association of genetic variants with tumor HPV16 status and survival in squamous cell carcinoma of the oropharynx.

    abstract:OBJECTIVES:Genetic polymorphisms of genes in cell cycle, apoptosis, and inflammation/immune response pathways may control the mechanisms of HPV clearance and HPV escape of immune surveillance and thus may affect both tumor HPV16 status and possibly related outcomes of squamous cell carcinoma of the oropharynx (SCCOP) p...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Feng Y,Li Y,Zhang Y,Zheng H,Li G

    更新日期:2016-05-01 00:00:00

  • miR-24 up-regulation in oral carcinoma: positive association from clinical and in vitro analysis.

    abstract::MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSC...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Lin SC,Liu CJ,Lin JA,Chiang WF,Hung PS,Chang KW

    更新日期:2010-03-01 00:00:00

  • Immediate knowledge increase from an oral cancer information leaflet in patients attending a primary health care facility: a randomised controlled trial.

    abstract::The aim was to determine the immediate influence of a validated patient information leaflet (PIL) on oral cancer and knowledge in primary care attenders. Participants were patients (n=800) attending their primary health care provider from 14 general practices (eight dental and six medical) in the north west of England...

    journal_title:Oral oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Humphris GM,Ireland RS,Field EA

    更新日期:2001-01-01 00:00:00

  • MicroRNAs as prognostic molecular signatures in human head and neck squamous cell carcinoma: a systematic review and meta-analysis.

    abstract::The aim of this study was to systematically review the articles investigating the prognostic value of different microRNAs (miRs) in human head and neck squamous cell carcinoma (HNSCC). Following the guidelines of the Meta-analysis of Observational Studies in Epidemiology group (MOOSE), we performed a broad and sensiti...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Jamali Z,Asl Aminabadi N,Attaran R,Pournagiazar F,Ghertasi Oskouei S,Ahmadpour F

    更新日期:2015-04-01 00:00:00

  • Intravenous myofibroblastic pseudotumour of the buccal mucosa.

    abstract::An intravenous pseudotumour at a traumatised site of the buccal mucosa of a 68-year-old woman is described. The lesion was composed of reactive spindle cell proliferation, merging of haphazard bizarre cells and inflammatory elements. Cellular morphology and immunohistochemical profile of proliferating cells reflected ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Ide F,Shimoyama T,Horie N

    更新日期:1998-05-01 00:00:00

  • Accuracy of intraoperative tissue staining in delineating deep surgical margins in oral carcinoma surgery.

    abstract::The purpose of this study was to assess the accuracy of this tissue staining assessment of surgical specimens in delineating deep surgical margins in oral cancer surgery. Fifteen patients who underwent surgery for oral carcinoma were included in the study. Once the tumor was resected, a vertical section of the surgica...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kurita H,Sakai H,Kamata T,Koike T,Kobayashi H,Kurashina K

    更新日期:2008-10-01 00:00:00

  • Severe late dysphagia and cause of death after concurrent chemoradiation for larynx cancer in patients eligible for RTOG 91-11.

    abstract:PURPOSE:The long-term results of RTOG 91-11 suggested increased deaths not attributed to larynx cancer after concomitant chemoradiotherapy (CRT) despite no apparent increase in late effects. Because the timing of events was not reported by RTOG 91-11, one possibility is that severe late dysphagia (SLD) develops beyond ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Ward MC,Adelstein DJ,Bhateja P,Nwizu TI,Scharpf J,Houston N,Lamarre ED,Lorenz R,Burkey BB,Greskovich JF,Koyfman SA

    更新日期:2016-06-01 00:00:00

  • Comorbidity in HPV+ and HPV- oropharyngeal cancer patients: A population-based, case-control study.

    abstract:OBJECTIVES:Comorbid conditions impact outcome for patients treated for oropharyngeal squamous cell carcinoma (OPSCC) and serve as competing risk factors for death. The purpose of this study was to examine differences in comorbidities in patients with OPSCC and known HPV-DNA. MATERIAL AND METHODS:We included patients d...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Grønhøj C,Kronberg Jakobsen K,Kjær E,Friborg J,von Buchwald C

    更新日期:2019-09-01 00:00:00

  • The efficacy and safety of PD-1/PD-L1 inhibitors in patients with recurrent or metastatic nasopharyngeal carcinoma: A systematic review and meta-analysis.

    abstract:OBJECTIVES:There is currently no effective salvage therapeutic modality that improves the survival outcomes of patients with recurrent or metastatic nasopharyngeal carcinoma. However, the programmed cell death protein 1 (PD-1) and its ligand (PD-L1) inhibitors may provide clinical benefit for these advanced patients. ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Wang BC,Cao RB,Fu C,Chen WB,Li PD,Lin GH,Qian XJ,Li YT,Liu Q

    更新日期:2020-05-01 00:00:00

  • Prognostic biomarkers in oral squamous cell carcinoma: A systematic review.

    abstract::Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/Pu...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Rivera C,Oliveira AK,Costa RAP,De Rossi T,Paes Leme AF

    更新日期:2017-09-01 00:00:00

  • Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: A systematic review and meta-analysis.

    abstract:INTRODUCTION:Salivary gland hypofunction is a common and permanent adverse effect of radiotherapy to the head and neck. Randomised trials of available treatment modalities have produced unclear results and offer little reliable guidance for clinicians to inform evidence-based therapy. We have undertaken this systematic...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Mercadante V,Al Hamad A,Lodi G,Porter S,Fedele S

    更新日期:2017-03-01 00:00:00

  • Management of regional nodes in thyroid cancer.

    abstract::Thyroid cancer metastasizes to regional lymph nodes early and often. The impact of these metastases on outcome depends on the histological subtype and the size, number and location of those metastases, as well as patient's age. Whilst clinically apparent lateral nodal metastases have a significant impact on both survi...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Nixon IJ,Shaha AR

    更新日期:2013-07-01 00:00:00

  • A prospective randomized controlled trial on the value of prophylactic oral nutritional supplementation in locally advanced nasopharyngeal carcinoma patients receiving chemo-radiotherapy.

    abstract:OBJECTIVES:We investigated the effect of prophylactic oral nutrition supplements (ONS) in locally advanced nasopharyngeal carcinoma patients receiving neoadjuvant chemotherapy and concurrent chemoradiotherapy (CCRT). METHODS:Eligible patients were randomly assigned to an intervention or control group. Patients in the ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Huang S,Piao Y,Cao C,Chen J,Sheng W,Shu Z,Hua Y,Jiang F,Hu Q,Chen X,Chen Y

    更新日期:2020-12-01 00:00:00

  • Predictors of severe long-term toxicity after re-irradiation for head and neck cancer.

    abstract:OBJECTIVE:To identify predictive factors of severe long-term toxicity after re-irradiation of recurrent/persistent or second-primary head and neck cancer. METHODS:Outcomes and treatment plans of patients who underwent modern IMRT based re-irradiation to the head and neck from 2008-2015 were reviewed. Co-variables incl...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Lee JY,Suresh K,Nguyen R,Sapir E,Dow JS,Arnould GS,Worden FP,Spector ME,Prince ME,McLean SA,Shuman AG,Malloy KM,Casper K,Bradford CR,Schipper MJ,Eisbruch A

    更新日期:2016-09-01 00:00:00

  • Primary oral melanoma: population-based incidence.

    abstract::Primary oral melanoma (POM) is a rare form of melanoma, generally diagnosed at a late stage and has poor prognosis. Epidemiological information has scarcely been reported in the literature over the past 40 years. Analyzing the Cancer Incidence in Five Continents volume IX (CI5-IX) database we found a total of 124,436 ...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究


    authors: Sortino-Rachou AM,Cancela Mde C,Voti L,Curado MP

    更新日期:2009-03-01 00:00:00

  • Tumor volume as a predictor of survival in T3 glottic carcinoma: A novel approach to patient selection.

    abstract:BACKGROUND:The optimal treatment for T3 glottic cancers continues to be debated. Organ preservation has become the standard of care, but not all tumors respond equally. The purpose of this was to investigate the long-term survival outcomes of organ preservation protocols based on tumor volume. METHODS:A retrospective ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Dziegielewski PT,Reschly WJ,Morris CG,DeJesus RD,Silver N,Boyce BJ,Santiago I 3rd,Amdur RJ,Mendenhall WM

    更新日期:2018-04-01 00:00:00

  • Multipotency of CD11bhighGr-1+ immature myeloid cells accumulating in oral squamous cell carcinoma-bearing mice.

    abstract::We demonstrated the accumulation of CD11b(high)Gr-1(+) cells in a murine model of squamous cell carcinoma (SCC). Inoculation of NR-S1K cells derived from oral SCC induced a rapid and clear accumulation of CD11b(high)Gr-1(+) cells in secondary lymphoid organs as well as in peripheral blood. Phenotypic and morphological...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Tanaka K,Jinhua P,Omura K,Azuma M

    更新日期:2007-07-01 00:00:00

  • Salivary endothelin-1 potential for detecting oral cancer in patients with oral lichen planus or oral cancer in remission.

    abstract::Endothelin-1 (ET-1) is a potent vasoconstrictor involved not only in vascular biology but also in carcinogenesis. Results of a study in 2007 suggested salivary ET-1 as a potential biomarker for oral squamous cell carcinoma (OSCC), but a later study showed conflicting results. The purpose of our pilot study was to inve...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Cheng YS,Rees T,Jordan L,Oxford L,O'Brien J,Chen HS,Wong D

    更新日期:2011-12-01 00:00:00

  • Treatment guidelines of lymphatic malformations of the head and neck.

    abstract::Lymphatic malformations, traditionally called lymphangiomas, are diseases caused by development errors of the lymphatic system. About 90% of the cases occur within 2years of age, except a few cases which occur in adulthood, and approximately 75% of the lesions are located in the head and neck region. The lesions can g...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Zhou Q,Zheng JW,Mai HM,Luo QF,Fan XD,Su LX,Wang YA,Qin ZP

    更新日期:2011-12-01 00:00:00

  • Ameloblastic fibro-odontoma: report of two cases.

    abstract::Ameloblastic fibro-odontoma is a rare odontogenic tumour. It affects young people and is usually located in the posterior jaws. Two cases of this tumour are presented: both lesions had produced an asymptomatic swelling. The histology showed the presence of an odontogenic epithelium immersed in a fibrous mesenchyme; de...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Favia GF,Di Alberti L,Scarano A,Piattelli A

    更新日期:1997-11-01 00:00:00

  • Clinical significance of molecular alterations in histologically negative surgical margins of head and neck cancer patients.

    abstract::The development of locoregional recurrence is the main reason for treatment failure in head and neck squamous cell carcinomas (HNSCC) and the remaining of tumor cells in surgical margins is associated with recurrence. Surgical margins are considered negative based on histologic assessment of the pathological specimen....

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: de Carvalho AC,Kowalski LP,Campos AH,Soares FA,Carvalho AL,Vettore AL

    更新日期:2012-03-01 00:00:00

  • Low incidence of H-, K- and N-ras oncogene mutations in cytological specimens of laryngeal tumours.

    abstract::Laryngeal cancer is a rare type of neoplasia, constituting approximately 2% of all human cancers. Mutations of the ras gene family is one of the main activating mechanisms in human cancer. Their involvement in head and neck cancer has been mainly demonstrated at the level of the overexpression whereas ras mutations in...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Rizos E,Sourvinos G,Arvanitis DA,Velegrakis G,Spandidos DA

    更新日期:1999-11-01 00:00:00

  • Determination of antibodies directed at EBV proteins expressed in both latent and lytic cycles in nasopharyngeal carcinoma.

    abstract:OBJECTIVES:Serologic analyses for anti-EBV antibodies used alone usually have low sensitivity for the diagnosis of nasopharyngeal carcinoma (NPC). We assumed that a combined determination of antibodies directed at EBV proteins expressed in both lytic and latent cycles could increase the sensitivity. MATERIALS AND METH...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Ai P,Wang T,Zhang H,Wang Y,Song C,Zhang L,Li Z,Hu H

    更新日期:2013-04-01 00:00:00