Incorporation and distribution of tritium in rats after chronic exposure to various tritiated compounds.


:Rats were chronically exposed to tritiated water (3HHO) and several tritiated organic compounds [( 3H]leucine, [3H]lysine, [3H]glucose, [3H]glucosamine, [3H]thymidine and [3H]uridine) dissolved in their drinking water. An analysis of tritium in wet and dry tissues of rats at the end of 22 days' chronic exposure showed that the chemical form of the ingested tritium was more important for tritium uptake in dry tissues than in wet tissues. The concentrations of tritium in dry tissues (organically bound tritium: OBT) after the exposure to tritiated organic compounds were consistently higher than after the exposure to 3HHO. The highest concentrations of OBT were found in rats exposed to tritiated amino acids [( 3H]lysine and [3H]leucine), which were 4-9 times higher than those in rats exposed to 3HHO. The next higher concentrations of OBT were found in rats exposed to [3H]uridine. The result of radiation dose estimations at the end of chronic exposure showed that the contribution of OBT to the total dose rate was higher in the tissues of rats exposed to tritiated organic compounds than that after the exposure to 3HHO. However, the differences between the total dose rates from 3HHO and those from tritiated organic compounds were within a factor of 2.


Int J Radiat Biol


Takeda H




Has Abstract


1991-03-01 00:00:00














  • Non-proportional involvement of Chinese hamster chromosomes 3, 4, 8 and 9 in X-ray-induced chromosomal aberrations.

    abstract:PURPOSE:To study by fluorescence in situ hybridization (FISH) the involvement of Chinese hamster chromosomes 3, 4, 8, and 9, and their separate chromosome arms in X-ray-induced aberrations. MATERIALS AND METHODS:Male embryonic primary cells of Chinese hamster were used and metaphases were collected and scored at 20 h ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Xiao Y,Natarajan AT

    更新日期:1999-08-01 00:00:00

  • Chromosomal aberration types in cells at the second division after irradiation in G1 or G2.

    abstract::Cultures of JU-56 cells were irradiated in either G1 or G2 and examined either in their first post-irradiation metaphase (in diploids) or in their second post-irradiation metaphase (in colcemid-induced tetraploids). The timing of fixation, together with tritiated thymidine pulse labelling, allowed selection for scorin...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Moore RC,Bender MA

    更新日期:1993-06-01 00:00:00

  • Comparative effects of UV A and UV B on clonogenic survival and delayed cell death in skin cell lines from humans and fish.

    abstract::The effects of UV radiation on humans and animals are receiving increasing attention and much interest has recently been focused on the environmental effects of UV A and UV B. This study compares the in vitro effects of UV A and UV B on the clonogenic survival of two human skin keratinocyte cell lines, HaCaT which are...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: O'Reilly JP,Mothersill C

    更新日期:1997-07-01 00:00:00

  • Proliferation saturation index in an adaptive Bayesian approach to predict patient-specific radiotherapy responses.

    abstract::Purpose: Radiotherapy prescription dose and dose fractionation protocols vary little between individual patients having the same tumor grade and stage. To personalize radiotherapy a predictive model is needed to simulate radiation response. Previous modeling attempts with multiple variables and parameters have been sh...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Sunassee ED,Tan D,Ji N,Brady R,Moros EG,Caudell JJ,Yartsev S,Enderling H

    更新日期:2019-10-01 00:00:00

  • Influence of low doses of gamma-irradiation on mouse skin collagen fibrils.

    abstract::The structure of mouse skin collagen fibrils after treatment with 0.5, 1 and 2.5 Gy gamma-irradiation was studied by electron microscopy. Animals were sacrificed 1, 4 and 8 weeks after irradiation. Although there were areas where the normal parallel packing of fibrils was retained in some regions packing was interrupt...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Tzaphlidou M,Kounadi E,Leontiou I,Matthopoulos DP,Glaros D

    更新日期:1997-01-01 00:00:00

  • Sonolysis of ubiquinone in aqueous solutions. An EPR spin-trapping study.

    abstract::Free radical formation in aqueous solutions of ubiquinone (coenzyme Qo) induced by ultrasound was studied by EPR and spin trapping with 3,5-dibromo-4-nitrosobenzene sulphonate. When aqueous solutions of ubiquinone were sonicated with 50-kHz ultrasound in the presence of argon or nitrogen, radicals formed by addition o...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Kondo T,Riesz P

    更新日期:1996-01-01 00:00:00

  • Cell-cycle variation in DNA migration in pulsed-field gel electrophoresis.

    abstract::Pulsed-field electrophoresis is being used extensively in the gene mapping studies and in the analysis of DNA strand breakage by ionizing radiation. We have evaluated the relationship between the fraction of S phase DNA in a cell population and its ability to modify the migration of DNA in pulsed-field gel electrophor...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Mateos S,Gordon AT,Steel GG,McMillan TJ

    更新日期:1996-06-01 00:00:00

  • Short-term magnetic field exposures (60 Hz) induce protection against ultraviolet radiation damage.

    abstract:PURPOSE:To investigate the ability of electromagnetic (EM) field pre-exposures to induce protection in chick embryos against subsequent ultraviolet (UV) light exposure. MATERIALS AND METHOD:Chick embryos in the 4th day of gestation were exposed for 20 minutes (short term) or 96 hours (long term) to 60 Hz, 8 microT mag...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Dicarlo AL,Hargis MT,Penafiel LM,Litovitz TA

    更新日期:1999-12-01 00:00:00

  • Radiation protection guidelines for the skin.

    abstract::The past recommendations of the ICRP about dose limits to the skin are reviewed. Recently, an ICRP Task Group has been revisiting the old arguments and setting them against new data. With the exception of the function of cells in the skin associated with immunocompetence, non-stochastic effects have been well characte...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审


    authors: Fry RJ

    更新日期:1990-04-01 00:00:00

  • The long-term effects of γ-radiation on the growth of Allium cepa plants.

    abstract:PURPOSE:The purpose of this study was to assess the long-term effects of gamma-radiation, including low-dose radiation, on growth parameters of onion (Allium cepa) seedling roots 6-10 days after irradiation. MATERIALS AND METHODS:Onion seedlings were exposed to a 137Cs gamma source at doses ranging from 0.1 to 10 gray...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Bolsunovsky A,Trofimova E,Dementyev D,Petrichenkov M

    更新日期:2020-11-16 00:00:00

  • Detrimental effect of UV-B radiation on growth, photosynthetic pigments, metabolites and ultrastructure of some cyanobacteria and freshwater chlorophyta.

    abstract:BACKGROUND:Global warming directly influencing ozone layer depletion, which eventually is increasing ultraviolet radiation penetration having far-reaching impacts on living biota. This particularly influences the primary producer microalgae which are the basic unit of food webs in the aquatic habitats. Therefore, it is...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: El-Sheekh MM,Alwaleed EA,Ibrahim A,Saber H

    更新日期:2020-12-03 00:00:00

  • Differential survival of murine small and large intestinal crypts following ionizing radiation.

    abstract::Radiation survival curves have been obtained for crypts in the small and large intestine of male BDF1 mice using the microcolony assay. Four regions of the small intestine and three regions of the large intestine were studied. One of the major objectives was to determine the optimal conditions for the microcolony assa...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Cai WB,Roberts SA,Bowley E,Hendry JH,Potten CS

    更新日期:1997-02-01 00:00:00

  • Concomitant low dose-rate irradiation and cisplatin treatment in ovarian carcinoma cell lines sensitive and resistant to cisplatin treatment.

    abstract::Human ovarian carcinoma parental and cisplatin-resistant cells were evaluated for their radiation sensitivity to high and low dose-rate irradiation and for the effectiveness of cisplatin in radiosensitization. The cisplatin resistant variant A2780cp showed increased radiation resistance for both low dose-rate (LDRI) a...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Raaphorst GP,Wang G,Stewart D,Ng CE

    更新日期:1996-05-01 00:00:00

  • Angiotensin II receptor antagonists in the treatment and prevention of radiation nephropathy.

    abstract:PURPOSE:Angiotensin-converting enzyme (ACE) inhibitors are effective in the prophylaxis of radiation-induced renal and lung injury. Studies were designed to determine whether blocking the angiotensin II (AII) receptor, rather than blocking AII synthesis with ACE inhibitors, would also be effective. MATERIALS AND METHO...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Moulder JE,Fish BL,Cohen EP

    更新日期:1998-04-01 00:00:00

  • Clinical interest in determinations of cellular radiation sensitivity.

    abstract::Determinations of cell sensitivity in terms of survival fraction after doses employed in clinical radiation therapy, say 1-3 Gy, are of increasing interest to clinicians as they provide direct experimental data which can be employed without reference to models of cell inactivation. SF2 values are expected ultimately t...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审


    authors: Suit HD,Baumann M,Skates S,Convery K

    更新日期:1989-11-01 00:00:00

  • Infrared spectroscopic demonstration of magnetic orientation in SH-SY5Y neuronal-like cells induced by static or 50 Hz magnetic fields.

    abstract::Purpose: To study the response of neuronal-like cells to an applied static or low-frequency magnetic field. Materials and methods: Fourier Transform Infrared (FTIR) Spectroscopy was used to investigate the overall behavior of SH-SY5Y neuronal-like cells exposed to a static or 50 Hz magnetic fields at intensities up to...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Calabrò E,Magazù S

    更新日期:2019-06-01 00:00:00

  • On the structure of thorium and americium adenosine triphosphate complexes.

    abstract:PURPOSE:The actinides are chemical poisons and radiological hazards. One challenge to better appraise their toxicity and develop countermeasures in case of exposure of living organisms is to better assess pathways of contamination. Because of the high chemical affinity of those actinide elements for phosphate groups an...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Mostapha S,Fontaine-Vive F,Berthon L,Boubals N,Zorz N,Solari PL,Charbonnel MC,Den Auwer C

    更新日期:2014-11-01 00:00:00

  • High split-dose recovery in hypersensitive human fibroblasts: a case of induced radioresistance?

    abstract::We studied the extent of split-dose recovery in seven non-transformed human fibroblast cell lines of different intrinsic radiosensitivity (HF19, 1BR3, 149BR, 84BR, GM739, 180BR and AT2EM). Experiments were performed on both growing and plateau-phase cells. The seven cell lines displayed a wide range of intrinsic radio...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Alsbeih MG,Fertil B,Arlett CF,Malaise EP

    更新日期:1996-02-01 00:00:00

  • Gamma and pulse radiolysis investigation of the reaction of desferrioxamine with superoxide anions.

    abstract::The kinetic scheme of the reaction of desferrioxamine (DFO) with O2-. was studied using pulse and gamma-radiolysis. The rate constant k(O2-. + DFO) is equal to 1.3 +/- 0.1 x 10(6) dm3 mol-1s-1 at pH 7.4. Studying the competition between DFO and ferricytochrome-c for O2-. generated by gamma-radiolysis, we observed that...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Sabourault D,Ribiere C,Nordmann R,Houee-Levin C,Ferradini C

    更新日期:1989-12-01 00:00:00

  • Ultrastructural morphometric analysis of peripheral nerves after intraoperative irradiation.

    abstract::Intraoperative irradiation (IORT) is used to enhance local tumour control by using large, single doses while removing critical structures from the treatment field. Peripheral nerve remains a dose-limiting normal tissue that often cannot be removed from the field. To assess ultrastructural changes in canine sciatic ner...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Vujaskovic Z,Gillette SM,Powers BE,Thurmond DN,Gillette EL,Colacchio TA

    更新日期:1995-07-01 00:00:00

  • Chromosome painting of radiation-induced micronuclei.

    abstract::In this report, in situ hybridization with whole chromosome painting probes was used to paint radiation-induced micronuclei (MN) in three lymphoblastoid cells lines to investigate the frequency of radiation-induced MN. The results obtained for four different chromosomes showed that there was a significant deviation of...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Slavotinek A,Sauer-Nehls S,Braselmann H,Taylor GM,Nüsse M

    更新日期:1996-10-01 00:00:00

  • Ultra-low dose beta-irradiation induces constriction of rabbit carotid arteries via the endothelium.

    abstract:PURPOSE:To investigate the action of ultra-low dose beta-radiation (ULDBR) on isolated segments of blood vessels. MATERIALS AND METHODS:We used the pharmacological model of isolated rabbit carotid arteries with intact or mechanically removed endothelium. Specific vascular responses to beta-irradiation were registered ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Zhirnov VV,Iakovenko IN

    更新日期:2005-11-01 00:00:00

  • Detection and sequencing of ionizing radiation-induced DNA rearrangements using the inverse polymerase chain reaction.

    abstract:PURPOSE:To develop a procedure, using the inverse polymerase chain reaction, to detect and sequence ionizing radiation-induced DNA rearrangements without prior phenotypic selection of mutant cells. METHOD:Normal human fibroblast cells (IMR-90) were given 30Gy of gamma-irradiation and then incubated at 37 degrees C for...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Forrester HB,Radford IR

    更新日期:1998-07-01 00:00:00

  • Automated micronucleus (MN) scoring for population triage in case of large scale radiation events.

    abstract:PURPOSE:In case of a large-scale radiation accident when hundreds of people may be exposed, it is important to distinguish the severely exposed individuals (> or =1 gray), who require early medical treatment, from those less exposed. The aim of our study was to develop a quick population triage method based on automate...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Willems P,August L,Slabbert J,Romm H,Oestreicher U,Thierens H,Vral A

    更新日期:2010-01-01 00:00:00

  • Cytotoxicity of cigarette smoke condensate is not due to DNA double strand breaks: Comparative studies using radiosensitive mutant and wild-type CHO cells.

    abstract:PURPOSE:To determine whether cigarette smoke condensate (CSC) without metabolic activation induces direct DNA double strand breaks (DSB) in the G1 phase of various radiosensitive mutants of CHO cells and whether these breaks display collateral hypersensitivity to CSC with respect to cell killing. MATERIALS & METHODS:W...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Kato T,Nagasawa H,Warner C,Okayasu R,Bedford JS

    更新日期:2007-09-01 00:00:00

  • Substructure in the radiation survival response at low dose: asynchronous and partially synchronized V79-WNRE cells.

    abstract::The radiation survival response of asynchronously-dividing populations of the cell line V79-WNRE indicates substructure in the low dose region that can be better characterized by separately fitting the data within the low and high dose regions to the linear-quadratic (LQ) equation. Flow cytometry and cell sorting tech...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Skwarchuk MW,Wouters BG,Skarsgard LD

    更新日期:1993-11-01 00:00:00

  • Chronic effects of single and fractionated γ-irradiation on an impairment of Th1-related immune response.

    abstract:PURPOSE:We already reported that levels of interferon (IFN)-γ have been shown to be markedly reduced in mice seven weeks after irradiation, resulting in a T helper (Th) 1/Th2 imbalance. To investigate whether the single or fractionated γ-irradiation induced an immune imbalance, we analysed the Th1-related immune respon...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Park HR,Jo SK,Eom HS

    更新日期:2011-05-01 00:00:00

  • A close correlation between electron spin resonance (ESR) dosimetry from tooth enamel and cytogenetic dosimetry from lymphocytes of Hiroshima atomic-bomb survivors.

    abstract:PURPOSE:To estimate gamma-ray doses received by Hiroshima atomic bomb survivors using electron spin resonance (ESR) of tooth enamel and to compare the results with cytogenetic data. MATERIALS AND METHODS:Tooth enamel ESR was performed for 100 teeth donated from 69 Hiroshima survivors, and conventional cytogenetic exam...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Nakamura N,Miyazawa C,Sawada S,Akiyama M,Awa AA

    更新日期:1998-06-01 00:00:00

  • Radiation retards muscle differentiation but does not affect osteoblastic differentiation induced by bone morphogenetic protein-2 in C2C12 myoblasts.

    abstract:PURPOSE:Effects of radiation on the differentiation of C2C12 myoblasts were studied using cell cultures in which the cells differentiated into either muscle cells or osteoblasts. MATERIALS AND METHODS:A mouse skeletal myoblast cell line, C2C12, was cultured and irradiated at confluence. Muscle differentiation was esti...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Ikeda S,Hachisu R,Yamaguchi A,Gao YH,Okano T

    更新日期:2000-03-01 00:00:00

  • The damage to phospholipids caused by free radical attack on glycerol and sphingosine backbone.

    abstract::The effect of gamma-radiation on aqueous solutions of saturated phospholipids, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol (DPPG), 1-palmitoyl-2-lyso-sn-glycero-3-phosphocholine (lysoPC), and bovine brain sphingomyelin (SM) has been investigated. It is shown that th...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Edimecheva IP,Kisel MA,Shadyro OI,Vlasov AP,Yurkova IL

    更新日期:1997-05-01 00:00:00