Incorporation and distribution of tritium in rats after chronic exposure to various tritiated compounds.


:Rats were chronically exposed to tritiated water (3HHO) and several tritiated organic compounds [( 3H]leucine, [3H]lysine, [3H]glucose, [3H]glucosamine, [3H]thymidine and [3H]uridine) dissolved in their drinking water. An analysis of tritium in wet and dry tissues of rats at the end of 22 days' chronic exposure showed that the chemical form of the ingested tritium was more important for tritium uptake in dry tissues than in wet tissues. The concentrations of tritium in dry tissues (organically bound tritium: OBT) after the exposure to tritiated organic compounds were consistently higher than after the exposure to 3HHO. The highest concentrations of OBT were found in rats exposed to tritiated amino acids [( 3H]lysine and [3H]leucine), which were 4-9 times higher than those in rats exposed to 3HHO. The next higher concentrations of OBT were found in rats exposed to [3H]uridine. The result of radiation dose estimations at the end of chronic exposure showed that the contribution of OBT to the total dose rate was higher in the tissues of rats exposed to tritiated organic compounds than that after the exposure to 3HHO. However, the differences between the total dose rates from 3HHO and those from tritiated organic compounds were within a factor of 2.


Int J Radiat Biol


Takeda H




Has Abstract


1991-03-01 00:00:00














  • Computer evaluation of direct and indirect damage induced by free and DNA-bound iodine-125 in the chromatin fibre.

    abstract:PURPOSE:When Iodine-125 decays within chromatin, several in vivo experiments have shown that the radiobiological effects are caused mainly by indirect mechanisms and that more than one DNA double strand break (DSB) is produced per decay. We present calculations to evaluate the contribution of direct and indirect effect...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Terrissol M,Edel S,Pomplun E

    更新日期:2004-11-01 00:00:00

  • Critical energies for ssb and dsb induction in plasmid DNA by vacuum-UV photons: an arrangement for irradiating dry or hydrated DNA with monochromatic photons.

    abstract:PURPOSE:Theoretical modelling techniques are often used to simulate the action of ionizing radiations on cells at the nanometre level. Using monoenergetic vacuum-UV (VUV) radiation to irradiate DNA either dry or humidified, the action spectra for the induction of DNA damage by low energy photons and the role of water a...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Folkard M,Prise KM,Vojnovic B,Brocklehurst B,Michael BD

    更新日期:2000-06-01 00:00:00

  • Radiation-induced apoptosis and necrosis in Molt-4 cells: a study of dose-effect relationships and their modification.

    abstract::Cell death induced by various radiation doses in Molt-4 and L5178Y cells was studied. Molt-4 cells have a low threshold for induction of interphase death while L5178Y cells have a high threshold. Interphase death in Molt-4 cells at doses > 100 Gy and in L5178Y cells at doses > 300 Gy showed typical necrosis. In contra...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Akagi Y,Ito K,Sawada S

    更新日期:1993-07-01 00:00:00

  • Radiosensitization by misonidazole, pimonidazole and azomycin and intracellular uptake in human tumour cell lines.

    abstract::The radiosensitization of two human tumour in vitro cell lines, HT-1080 and LoVo, has been compared with that of the Chinese hamster cell line V79-379A. Although the two human tumour cell lines were more radiosensitive than the V79 cell line sensitizer, enhancement ratios for misonidazole, pimonidazole and azomycin we...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Watts ME,Dennis MF,Roberts IJ

    更新日期:1990-02-01 00:00:00

  • Investigation of new cytogenetic biomarkers specific to high-LET radiation using in vivo and in vitro exposed human lymphocytes.

    abstract:PURPOSE:To find detectable cytogenetic biomarkers that can offer information about the radiation quality of in vivo exposure retrospectively. MATERIALS AND METHODS:Chromosome-type aberrations of peripheral lymphocytes of uterine cancer patients that received internal gamma- and external X-ray therapy or carbon beam th...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Kanda R,Minamihisamatsu M,Tsuji S,Ohmachi Y,Hiraoka T,Shimada Y,Ogiu T,Ohno T,Hayata I

    更新日期:2006-07-01 00:00:00

  • Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers.

    abstract:PURPOSE:The chromosomal radiosensitivity of a selected group of familial breast cancer patients carrying a mutation in BRCA1 (n=11) or BRCA2 (n=9) and a group of healthy mutation carriers (n=12) was investigated and compared to a reference group of breast cancer patients without a BRCA1/2 mutation (n=78) and a group of...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Baeyens A,Thierens H,Claes K,Poppe B,de Ridder L,Vral A

    更新日期:2004-10-01 00:00:00

  • Multicellular tumour spheroids in radiation biology.

    abstract:PURPOSE:Multicellular tumour spheroids are being used with increasing frequency in various aspects of tumour biology, including studies dealing with radiation biology. This review attempts to outline recent studies using these three-dimensional systems in radiation biology with particular reference made to papers testi...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审


    authors: Santini MT,Rainaldi G,Indovina PL

    更新日期:1999-07-01 00:00:00

  • Biodosimetry using chromosomal translocations measured by FISH in a population chronically exposed to low dose-rate 60Co gamma-irradiation.

    abstract:PURPOSE:To evaluate the cumulative gamma-radiation personal exposure by analysing lymphocyte chromosome translocations using FISH painting and to compare FISH-derived biodoses with those derived from retrospective physical dose reconstruction in residents receiving chronic low dose-rate gamma-irradiation while living i...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Hsieh WA,Lucas JN,Hwang JJ,Chan CC,Chang WP

    更新日期:2001-07-01 00:00:00

  • Chironomus ramosus larvae exhibit DNA damage control in response to gamma radiation.

    abstract:PURPOSE:Chironomus ramosus is one of the recently reported radiotolerant insects. Salivary gland cells of fourth instar larvae respond to ionizing radiations with increases in the levels of antioxidant enzymes and chaperone proteins. Here we made an attempt to study the state of nuclear DNA after exposure of larvae to ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Datkhile KD,Gaikwad PS,Ghaskadbi SS,Mukhopadhyaya R,Nath BB

    更新日期:2015-01-01 00:00:00

  • Evidence for curvilinearity in the cancer incidence dose-response in the Japanese atomic bomb survivors.

    abstract::The recently released data on cancer incidence in the Japanese atomic bomb survivors are analysed using a variety of relative risk models which take account of errors in estimates of dose to assess the dose-response at low doses. For all solid cancers analysed together there is a significant positive dose-response (at...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Little MP,Muirhead CR

    更新日期:1996-07-01 00:00:00

  • Chronic effects of single and fractionated γ-irradiation on an impairment of Th1-related immune response.

    abstract:PURPOSE:We already reported that levels of interferon (IFN)-γ have been shown to be markedly reduced in mice seven weeks after irradiation, resulting in a T helper (Th) 1/Th2 imbalance. To investigate whether the single or fractionated γ-irradiation induced an immune imbalance, we analysed the Th1-related immune respon...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Park HR,Jo SK,Eom HS

    更新日期:2011-05-01 00:00:00

  • Hematopoietic death of unprotected man from photon irradiations: statistical modeling from animal experiments.

    abstract::Most estimates of the radiation dose lethal to 50 per cent of a human population are based on historical data taken from well-known experiences reflecting inadequately known physical and biological conditions, or from medical procedures where individual patients received advantages of modern clinical care. It has been...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Morris MD,Jones TD

    更新日期:1989-03-01 00:00:00

  • Pain-relieving effects of pulsed magnetic fields in a rat model of carrageenan-induced hindpaw inflammation.

    abstract:PURPOSE:Many strategies have been investigated to exclude the several side-effects of pharmacological or invasive treatments. Non-invasive pulsed magnetic field (PMF) treatment with no toxicity or side-effects can be an alternative to pharmacologic treatments. The purpose of this study was, therefore, to investigate th...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Mert T,Ocal I,Cinar E,Yalcin MS,Gunay I

    更新日期:2014-01-01 00:00:00

  • Mitophagy and mitochondrial morphology in human melanoma-derived cells post exposure to simulated sunlight.

    abstract:PURPOSE:To assess changes in mitochondrial morphology and mitophagy induced by simulated sunlight irradiation (SSI) and how these changes are modulated by mitochondrial activity and energy source. MATERIALS AND METHODS:Human malignant amelanotic melanoma A375 cells were pre-treated with either a mitochondrial activity...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Zanchetta LM,Garcia A,Lyng F,Walsh J,Murphy JE

    更新日期:2011-05-01 00:00:00

  • The relationship between the anoxic sensitivity and the extent of sensitization by nitrous oxide.

    abstract::Nitrous oxide reacts during irradiation to increase the yield of .OH, a radical many believe to be a major cause of lethality. Logically, one would expect N2O to be a radiation sensitizer. In some instances it is, while in others it is not. In some cases we can explain why N2O fails to sensitize; factors such as dose ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Ewing D,Walton HL,Guilfoil DS,Ohm MB

    更新日期:1991-03-01 00:00:00

  • Formation of two double-strand breaks in the same DNA molecule by a single high-energy photon or ionizing particle.

    abstract::I calculate the probability that a single high-energy ionizing particle or photon makes two widely spaced double-strand breaks in the same DNA molecule. Deletions (or inversions) between two breaks formed by the same incident particle are linear in radiation dose and occur even at extremely low dose-rates; deletions b...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Hutchinson F

    更新日期:1996-11-01 00:00:00

  • Age-dependent changes in oxygen tension, radiation dose and sensitivity within normal and diseased coronary arteries-Part B: modeling oxygen diffusion into vessel walls.

    abstract:PURPOSE:The aim is to assess the change with age and disease of the oxygen concentration within the coronary artery walls. MATERIALS AND METHODS:In an accompanying paper, Part A, the age-dependent morphology and composition for the wall layers of normal and diseased coronary arteries were developed from published data...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Richardson RB

    更新日期:2008-10-01 00:00:00

  • Increased chromatid-type chromosomal aberrations in mouse m5S cells exposed to power-line frequency magnetic fields.

    abstract:PURPOSE:To investigate the induction of chromosomal aberrations in mouse m5S cells after exposure to power-line frequency magnetic fields (extremely low frequency magnetic fields; ELFMF) at high-flux densities. MATERIAL AND METHOD:m5S cells were either untreated or pretreated during the G1 phase with mitomycin C (MMC,...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Yaguchi H,Yoshida M,Ding GR,Shingu K,Miyakoshi J

    更新日期:2000-12-01 00:00:00

  • The ability of hypoxia to modify the gene expression of thymidylate synthase in tumour cells in vivo.

    abstract:PURPOSE:Hypoxic cells in tumours are resistant to 5-fluorouracil (5-FU). This in vivo study investigated the ability of hypoxia to regulate the gene expression of thymidylate synthase (TS), the target enzyme of 5-FU. MATERIALS AND METHODS:C3H mammary carcinomas, grown in the feet of female CDF1 mice, were used for all...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Ehrnrooth E,von der Maase H,Sørensen BS,Poulsen JH,Horsman MR

    更新日期:1999-07-01 00:00:00

  • Weiss lecture. The dose-rate factor in radiation biology.

    abstract::The dose-rate effect has been the topic of extensive radiobiological studies and has important implications in radiation therapy and in the field of radiation protection. Three examples will be discussed: two in radiation therapy and one in protection. First, continuous low dose-rate interstitial brachytherapy may be ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审


    authors: Hall EJ

    更新日期:1991-03-01 00:00:00

  • Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys.

    abstract::Purpose: To examine the effects of low-dose exposure to uranium with a systems biology approach, a multiscale high-throughput multi-omics analysis was applied with a protocol for chronic exposure to the rat kidney. Methods: Male and female rats were contaminated for nine months through their drinking water with a nont...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Grison S,Kereselidze D,Cohen D,Gloaguen C,Elie C,Lestaevel P,Legendre A,Manens L,Habchi B,Benadjaoud MA,Tarlet G,Milliat F,Martin JC,Lobaccaro JM,Souidi M

    更新日期:2019-06-01 00:00:00

  • Locus specificity for mutation induction in human cells exposed to accelerated heavy ions.

    abstract::The relative efficiencies of two types of densely ionizing particles were compared for the induction of mutations at two distinct genetic loci in human cells. Mutations to 6-thioguanine resistance (hgprt locus) or to trifluorothymidine resistance (tk) locus were scored in TK6 human lymphoblastoid cells exposed to grad...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Kronenberg A,Little JB

    更新日期:1989-06-01 00:00:00

  • A comprehensive study of p53 transcriptional activity in thymus and spleen of gamma irradiated mouse: high sensitivity of genes involved in the two main apoptotic pathways.

    abstract:PURPOSE:Gamma-irradiation leads to activation of p53 tumour suppressor gene and to p53-dependant stimulation of a large panel of cellular genes including proapoptotic genes involved in intrinsic and extrinsic pathways. Most in vivo published data referred to high (lethal) irradiation doses. The present study was perfor...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Alvarez S,Drané P,Meiller A,Bras M,Deguin-Chambon V,Bouvard V,May E

    更新日期:2006-11-01 00:00:00

  • Marrow stromal cell recovery after radiation-induced aplasia in mice.

    abstract:PURPOSE:The identification of fibroblast-like cells of the marrow stroma by means of alkaline phosphatase (ALP) cytochemistry reveals delicate ALP-positive structures interspersed among haematopoietic cells and arranged in a loosely meshed network. These cells are often referred to as 'reticular' cells and the network ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Almohamad K,Thiry A,Hubin F,Belaid Z,Humblet C,Boniver J,Defresne MP

    更新日期:2003-04-01 00:00:00

  • The in vivo effects of low-intensity radiofrequency fields on the motor activity of protozoa.

    abstract:PURPOSE:To analyze the direct and transgenerational effects of exposure to low-dose 1 GHz (mobile phone/wireless telecommunication range) and 10 GHz (radar/satellite communication range) radiofrequency electromagnetic fields (RF-EMF) on the motility of ciliates Spirostomum ambiguum. MATERIALS AND METHODS:S. ambiguum w...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Sarapultseva EI,Igolkina JV,Tikhonov VN,Dubrova YE

    更新日期:2014-03-01 00:00:00

  • Neuroprotective effects of melatonin and omega-3 on hippocampal cells prenatally exposed to 900 MHz electromagnetic fields.

    abstract:PURPOSE:Adverse effects on human health caused by electromagnetic fields (EMF) associated with the use of mobile phones, particularly among young people, are increasing all the time. The potential deleterious effects of EMF exposure resulting from mobile phones being used in close proximity to the brain require particu...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Erdem Koç G,Kaplan S,Altun G,Gümüş H,Gülsüm Deniz Ö,Aydin I,Emin Onger M,Altunkaynak Z

    更新日期:2016-10-01 00:00:00

  • Radiation metabolomics in the quest of cardiotoxicity biomarkers: the review.

    abstract::Purpose: Ionizing radiation is a risk factor to the whole organism, including the heart. Cardiac damage is considered to be a late effect of radiation exposure. While the acute cardiotoxicity of high doses is well characterized, the knowledge about nature and magnitude of the cardiac risk following lower doses exposur...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审


    authors: Gramatyka M,Sokół M

    更新日期:2020-03-01 00:00:00

  • Protection of pig epidermis against radiation-induced damage by the infusion of BW12C.

    abstract::BW12C, which was developed as an agent for the treatment of sickle cell anaemia, increases the binding of oxygen to haemoglobin and hence reduces the availability of oxygen to tissues. Due to these changes in oxygen availability BW12C could act as a protector against radiation-induced injury to normal tissues. In this...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: van den Aardweg GJ,Hopewell JW,Adams GE,Barnes DW,Sansom JM,Stratford IJ,Nethersell AB

    更新日期:1991-04-01 00:00:00

  • Correlation between mitotic delay and aberration burden, and their role for the analysis of chromosomal damage.

    abstract::The aim was to investigate further the relationship between radiation-induced mitotic delay and the expression of chromosome damage in V79 cells. Recently published data on the time-course of chromosome aberrations in V79 first-cycle metaphases after exposure to 10.4 MeV u(-1) Ar ions (LET = 1226 keV microm(-1)) were ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Gudowska-Nowak E,Kleczkowski A,Nasonova E,Scholz M,Ritter S

    更新日期:2005-01-01 00:00:00

  • In vitro radiosensitivity measured in lymphocytes and fibroblasts by colony formation and comet assay: comparison with clinical acute reactions to radiotherapy in breast cancer patients.

    abstract:PURPOSE:To compare colony-forming and comet assays on fibroblasts and lymphocytes of 32 breast cancer patients irradiated after breast-conserving operations and to correlate the results with acute clinical radiation reactions in the skin. MATERIAL AND METHODS:Skin fibroblasts were isolated and cultivated before radiot...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Oppitz U,Schulte S,Stopper H,Baier K,Müller M,Wulf J,Schakowski R,Flentje M

    更新日期:2002-07-01 00:00:00