Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products.

Abstract:

:The E3 region of adenovirus induces down-regulation of epidermal growth factor receptor (EGFR) through endocytosis. Here we report that an EGFR-related protein, the HER-2/c-erbB-2 gene product, p185, is also down-regulated by adenovirus, but via a different mechanism. We found that the adenovirus E1a gene is responsible for the repression of HER-2/c-erbB-2 at the RNA level.

journal_name

Oncogene

journal_title

Oncogene

authors

Yan DH,Chang LS,Hung MC

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

343-5

issue

2

eissn

0950-9232

issn

1476-5594

journal_volume

6

pub_type

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