Epidermal growth factor receptor expression regulates proliferation in the postnatal rat retina.

Abstract:

:Epidermal growth factor (EGF) is known to promote proliferation of both retinal progenitors and Muller glia in vitro, but several questions remain concerning an in vivo role for this factor. In this study, we investigated whether the EGF receptor (EGFR) is necessary for the maintenance of normal levels of progenitor and Muller glial proliferation in vivo. Here, we show that (1) mice with homozygous deletion of the Egfr gene have reduced proliferation in late stages of retinal histogenesis, (2) EGF is mitogenic for Müller glia in vivo during the first two postnatal weeks in the rodent retina, (3) the effectiveness of EGF as a Müller glial mitogen declines in parallel with the decline in EGFR expression as the retina matures, and (4) following damage to the retina from continuous light exposure, EGFR expression is up-regulated in Müller glia to levels close to those in the neonatal retina, resulting in a renewed mitotic response to EGF. Together with previous results from other studies, these data indicate that the downregulation of a growth factor receptor is one mechanism by which glial cells maintain mitotic quiescence in the mature nervous system.

journal_name

Glia

journal_title

Glia

authors

Close JL,Liu J,Gumuscu B,Reh TA

doi

10.1002/glia.20361

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

94-104

issue

2

eissn

0894-1491

issn

1098-1136

journal_volume

54

pub_type

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