Abstract：
:In this work the effect of a novel compound, 5-epi-icetexone (ICTX) obtained from Salvia gilliessi Benth. (Labiatae), is studied on cultured epimastigotes of Trypanosoma cruzi (Tulahuen). It was found that the compound exerts an antiproliferative effect on the parasites at concentrations between 2.8 and 4.2 microM, and similar sensitivity in other strains (Dm28c, CL-Brener and Y-strain). The compound was deleterious at concentrations higher than 4.2 microM, with an estimated IC50 of 6.5+/-0.75 microM, but with low cytotoxicity to mammalian cells. These effects were irreversible, even at short times of exposure to the drug. In solution, ICTX showed to be stable for at least 96 h at 29 degrees C. With cytostatic dose a little percentage of parasites was resistant to the action of ICTX, and they continued growing although with different kinetic. By electron transmission microscopy, at dose of 4.2 microM an external vesiculization was observed on the first day of exposure to the compound, but the parasite cytoplasm became plenty of vacuoles and exhibited nuclear disorganization from the second day of exposure. It was concluded that ICTX is active against T. cruzi and may act by multiple mechanisms. In future, this novel icetexane diterpene may be a good candidate for therapeutic use against Chagas' disease.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Sanchez AM,Jimenez-Ortiz V,Sartor T,Tonn CE,García EE,Nieto M,Burgos MH,Sosa MAdoi
10.1016/j.actatropica.2005.12.007subject
Has Abstractpub_date
2006-05-01 00:00:00pages
118-24issue
2eissn
0001-706Xissn
1873-6254pii
S0001-706X(06)00045-3journal_volume
98pub_type
杂志文章相关文献
ACTA TROPICA文献大全abstract：:Malaria in pregnancy is associated with increased risks of maternal anemia, spontaneous abortion, low birth weight, premature delivery and other adverse effects on health. In Brazil, disease transmission is highly concentrated in the multi-state region that constitutes the Brazilian Amazon (more than 99% of all cases)...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2012.11.004
更新日期：2013-02-01 00:00:00
abstract：:Extracellular vesicles (EVs) play a key role in host-parasite interactions. Previous studies have shown that parasites can release microRNA (miRNA) containing EVs, which can transfer their contents to host cells and regulate gene expression in recipient cells. However, a little is known about the secretion of EVs by t...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2020.105718
更新日期：2020-12-01 00:00:00
abstract：:Anopheles mosquitoes are important candidates for genetic control strategies. However, little is known about sperm quality and quantity as determinants of male reproductive success. In this study, sperm quantity and length variation were assessed in testes of un-irradiated and irradiated Anopheles arabiensis. Male rep...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.10.002
更新日期：2009-01-01 00:00:00
abstract：:17-N-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) is an inhibitor of heat shock protein 90 (Hsp90), which has been studied in the treatment of cancer such as leukemia or solid tumors. Alternatively, 17-AAG may represent a promising therapeutic agent against leishmaniasis. However, the delivery of 17-AAG ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2020.105595
更新日期：2020-11-01 00:00:00
abstract：:Paragonimiasis is a subacute to chronic inflammatory granulomatous lung disease caused by the genus Paragonimus. In Latin America Paragonimus mexicanus Miyazaki & Ishii, 1968 is the only confirmed species to cause human infections. Paragonimus caliensis Little, 1968 is an uncommon species often regarded as a synonym o...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.03.024
更新日期：2018-07-01 00:00:00
abstract：:Giardiasis is a major problem in León, Nicaragua, yet despite this no data are available regarding the prevalence of different Giardia genotypes in this area. To address this question, a molecular analysis of Giardia isolates from humans and dogs living in the same area in León, Nicaragua was performed. Giardia isolat...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.01.004
更新日期：2008-04-01 00:00:00
abstract：:Benzimidazoles, including albendazole and mebendazole, are the major drugs for clinical chemotherapy of echinococcosis. They mainly exert parasitostatic effects depending on high dosages for long-term. Previous studies have identified carbazole aminoalcohols as novel anti-CE (cystic echinococcosis) agents. However, it...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.05.007
更新日期：2018-09-01 00:00:00
abstract：:Antigen-detection enzyme immunoassays (ELISA) were used for the diagnosis of Trypanosoma vivax, T. congolense and T. brucei in N'Dama cattle in Gabon, Central Africa. The assays are based on monoclonal antibodies which recognise trypanosome antigens specific for each of the three species and animals were termed 'antig...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(91)90068-u
更新日期：1991-11-01 00:00:00
abstract：:Antimicrobial resistance results in selective colonization in animals. In the present study, 447 diarrheic foals (235 horse foals, 165 donkey foals and 47 mule foal) were selected from Lahore and Sahiwal districts of Punjab, Pakistan. Fresh fecal and blood samples from diarrheic foals were collected for isolation and ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.08.003
更新日期：2017-12-01 00:00:00
abstract：:Glugea eda n. sp. is described from the mesenteries of the striated fusilier, Caesio striata, collected from the Red Sea coast off Yanbu' al Bahr, Saudi Arabia. Numerous blackish xenomas, ranged from 3 to 5 mm, were found in the body cavity associated with the mesenteries. Mature spores are monomorphic, ellipsoidal wi...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2020.105331
更新日期：2020-04-01 00:00:00
abstract：:The larval development of Schistosoma rodhaini in Biomphalaria glabrata presents two features of interest. The first concerns the migration of daughter sporocysts: only a fraction of the daughter sporocysts produced by the mother sporocyst migrate directly towards the digestive gland of the snail and become cercarioge...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(89)90014-4
更新日期：1989-01-01 00:00:00
abstract：:Parenteral quinine is the most frequently used first line treatment for severe Plasmodium falciparum malaria in the developed world. Quinine is known to have a number of toxic side effects including cardiotoxicity, ototoxicity and ocular toxicity. Many therefore advocate routine monitoring of quinine levels for patien...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2005.11.006
更新日期：2006-02-01 00:00:00
abstract：:Bovine cryptosporidiosis is mainly caused by four distinct species: Cryptosporidium parvum, C. bovis, C. ryanae and C. andersoni. The first, C. parvum, is a major concern in livestock causing economic losses, in addition to public health impact because of its zoonotic characteristics. The present study aimed to determ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2013.11.002
更新日期：2014-02-01 00:00:00
abstract：:Leishmaniasis is an epidemic in various countries, and the parasite Leishmania donovani is developing resistance against available drugs. In the present study the antileishmanial action of piperolactam A (PL), isolated after bioactivity guided fractionation from root extracts of Piper betle was accentuated in detail. ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2016.02.017
更新日期：2016-06-01 00:00:00
abstract：:The anthelmintic activity of 11 benzimidazole derivatives (A1-A11) and 2 thioureides N,N'-disubstituted (B1-B2) was determined. Each compound and albendazole was tested in vitro against Toxocara canis larvae and in vivo against Hymenolepis nana adult. Compounds A1-A6 and B1-B2 were designed as albendazole prodrugs. Co...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.11.014
更新日期：2009-03-01 00:00:00
abstract：:The small mammal fauna of coffee plantations in SW Colombia was surveyed to determine which of the species present were infected with parasites of the Leishmania (Viannia) braziliensis complex and might therefore act as reservoirs of human cutaneous leishmaniasis. Fifty animals of seven different species were captured...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(97)00114-9
更新日期：1998-03-01 00:00:00
abstract：:The study aimed to establish if there was any relationship between the blood group of the human host and schistosomiasis prevalence, intensity, incidence and related organ pathology. Urine and stool specimens were collected from the 735 school children attending a rural school in Zimbabwe to determine the Schistosoma ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(97)00671-2
更新日期：1997-05-30 00:00:00
abstract：:Symptomatic chronic Chagas disease affects up to 40% of patients infected with Trypanosoma cruzi. The lack of reliable early markers of cure after therapy hinders disease management and clinical trials with new drugs. We performed a study with 18 months of follow-up to compare changes in immune parameters and T. cruzi...
journal_title：Acta tropica
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.actatropica.2016.09.010
更新日期：2016-12-01 00:00:00
abstract：:Pangonius theodori a new horse fly species (Diptera: Tabanidae: Pangoniinae) from northern Israel and southern Lebanon is described. The zoogeography, habitat preference and taxonomic position within the genus of the new species is discussed in detail. ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2012.11.009
更新日期：2013-03-01 00:00:00
abstract：:The most severe clinical form of American tegumentary leishmaniasis (ATL) due to Leishmania braziliensis is mucosal leishmaniasis (ML), characterized by destructive lesions in the facial mucosa. We performed a retrospective cohort study of 109 ATL patients from Rio de Janeiro State, Brazil, where ATL is caused by L. b...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2015.10.015
更新日期：2016-02-01 00:00:00
abstract：:Species of Haemoproteus (Haemosporida, Haemoproteidae) are widespread and often prevalent blood parasites of birds all over the word. They are particularly diverse in tropical countries. Due to limited knowledge of life cycles, these pathogens usually have been considered relatively benign and were neglected in veteri...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.105051
更新日期：2019-09-01 00:00:00
abstract：:The food selection behaviour of two fish species indigenous to Zimbabwe (Tilapia rendalli and Sargochromis codringtoni) was studied under laboratory conditions with a view to considering them as biological agents for snail control. Six glass aquaria were set up and divided into two sets each with two aquaria. One S. c...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(95)00144-4
更新日期：1996-05-01 00:00:00
abstract：:Antibodies to the variable antigen type (VAT) designated LiTat 1.3 are common in sera from parasitologically confirmed patients with gambian sleeping sickness. For this reason, LiTat 1.3 has been considered a suitable antigen for detecting Trypanosoma brucei gambiense in the Card Agglutination Test for Trypanosomiasis...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(92)90054-2
更新日期：1992-06-01 00:00:00
abstract：:Leishmaniasis due to Leishmania infantum (syn. L. chagasi) infection is a zoonotic disease present mainly in Mediterranean basin, central Asia and Brazil. Besides a limited number of human cases of clinical visceral leishmaniasis, a great number of infections remains asymptomatic. In this review, the prevalence of asy...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2011.05.012
更新日期：2011-08-01 00:00:00
abstract：:The semiargenteus-subgroup of the Tabanus bovinus species group is reviewed. The known distribution area of the three previously known species could be significantly increased. T. semiargenteus Olsufjev, 1937 was for the first time recorded from Syria and Iran, T. olsufjevi Hauser, 1960 from Iraq and Iran and T. sarba...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2014.04.027
更新日期：2014-09-01 00:00:00
abstract：:Northern Côte d'Ivoire is the main livestock breeding zone and has the highest livestock cross-border movements in Côte d'Ivoire. The aim of this study was to provide updated epidemiological data on three neglected zoonotic diseases, namely brucellosis, Q Fever and Rift Valley Fever (RVF). We conducted three-stage cro...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2016.02.012
更新日期：2017-01-01 00:00:00
abstract：:The last 40 years, beginning with the first TIROS (television infrared observational satellite) launched on 1 April 1960, has seen an explosion of earth environmental satellite systems and their capabilities. They can provide measurements in globe encircling arrays or small select areas, with increasing resolutions, a...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/s0001-706x(01)00101-2
更新日期：2001-04-27 00:00:00
abstract：:The antidiarrhoeal effects of the methanol extract of Zizyphus spina-christi stem bark were evaluated in laboratory rodents. Studies on castor oil induced diarrhoea, intraluminal fluid accumulation, and gastrointestinal transit time were carried out. Results obtained revealed that the extract caused a dose dependent p...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(03)00114-1
更新日期：2003-07-01 00:00:00
abstract：:The Fast Agglutination Screening Test (FAST) was employed on sera obtained from an endemic area of visceral leishmaniasis in southwestern Ethiopia, in February 2000. The study involved (i) active case detection among 1575 residents of two villages; and (ii) passive case detection in an outpatient clinic. Sera of 1587 ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(02)00063-3
更新日期：2002-08-01 00:00:00
abstract：:Balantioides coli is a known ciliated zoonotic protozoan that mainly causes diarrhea in humans and pigs. An efficient and reliable culture system for this parasite remains unavailable until now. In this study, a modified Dulbecco's modified eagle medium (DMEM) with pH 7.0-7.5, containing 5 mg/mL starch and 20% new cal...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2020.105762
更新日期：2020-11-21 00:00:00
