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Cortical modulation of dorsal column nuclei: a computational study.

Abstract：

:We present a computational study aimed at exploring the sensorimotor cortex modulation of the behaviour of dorsal column nuclei, specifically the impact of synaptic parameters, during both sleep and waking conditions. On the basis of the circuit proposed by Canedo et al. (2000), we have developed realistic computational models that have been tested with simultaneous electrocorticographic as well as intracellular cuneate recordings performed in anaesthetized cats. The results show that, (1) under sleep conditions, the model can block the transmission of afferent sensory information and, (2) operations expected during wakefulness, such as filtering and facilitation, can be performed if synaptic parameters are appropriately tuned.

journal_name

J Comput Neurosci

journal_title

Journal of computational neuroscience

authors

Sánchez E,Barro S,Mariño J,Canedo A

doi

10.1007/s10827-006-7058-5

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

21-33

issue

1

eissn

0929-5313

issn

1573-6873

journal_volume

21

pub_type

杂志文章

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