Limited regression of central giant cell granuloma by interferon alpha after failed calcitonin therapy: a report of 2 cases.

Abstract:

:Central giant cell granuloma (CGCG) is a benign lesion of the jaws with a sometimes locally aggressive behaviour. The most common therapy is surgical curettage which has a high recurrence rate, especially in lesions with aggressive signs and symptoms (i.e. pain, paresthesia, root-resorption and rapid growth). Alternative therapies such as interferon alpha (INFalpha) or calcitonin are described in the literature. In this study 2 patients with an aggressive CGCG are presented who were treated with INF mono-therapy. INF mono-therapy was capable of terminating the rapid growth of the lesion in both patients and induced a partial reduction. Total resolution, however, was not obtained and alternative treatment is still necessary.

authors

de Lange J,van den Akker HP,van den Berg H,Richel DJ,Gortzak RA

doi

10.1016/j.ijom.2006.02.011

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

865-9

issue

9

eissn

0901-5027

issn

1399-0020

pii

S0901-5027(06)00109-3

journal_volume

35

pub_type

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