Polymorphisms in the p53 pathway.

abstract：:Dlk/ZIP kinase is a newly discovered serine/threonine kinase which, due to its homology to DAP kinase, was named DAP like kinase, Dlk. This kinase is tightly associated with nuclear structures, it undergoes extensive autophosphorylation and phosphorylates myosin light chain and core histones H3, H2A and H4 in vitro. M...

journal_title：Oncogene

authors： Page G,Kögel D,Rangnekar V,Scheidtmann KH

更新日期：1999-12-02 00:00:00

abstract：:We previously reported that overexpression of the 24 kDa basic fibroblast factor (or FGF-2) isoform provides protection from the cytotoxic effect of ionizing radiation (IR). DNA double-strand breaks (DSB), the IR-induced lethal lesions, are mainly repaired in human cells by non-homologous end joining system (NHEJ). NH...

journal_title：Oncogene

authors： Ader I,Muller C,Bonnet J,Favre G,Cohen-Jonathan E,Salles B,Toulas C

更新日期：2002-09-19 00:00:00

abstract：:In mammalian cells, the p53 protein is a key regulator of the cell cycle following DNA damage. In the present study, we investigated the function of p53 in the A6 amphibian cell line. Using various specific Xenopus p53 monoclonal antibodies, we showed that Xenopus p53 accumulates after DNA damage, including gamma and ...

journal_title：Oncogene

authors： Bensaad K,Rouillard D,Soussi T

更新日期：2001-06-28 00:00:00

abstract：:Pim kinases are found to be highly expressed in leukemia, lymphoma, prostate and pancreatic cancer. Bitransgenic mice overexpressing either Pim-1 or Pim-2 and c-Myc succumb to pre-B-cell lymphoma at a strikingly accelerated speed. Despite that Pim-1/Pim-2 has long been recognized as a strong synergistic partner with c...

journal_title：Oncogene

authors： Zhang Y,Wang Z,Li X,Magnuson NS

更新日期：2008-08-14 00:00:00

abstract：:The Notch ligand delta-like ligand 4 (DLL4) is an essential component expressed by endothelial tip cells during angiogenic sprouting. We have described a conceptually novel therapeutic strategy for targeting tumor angiogenesis and endothelial tip cells based on DNA vaccination against DLL4. Immunization with DLL4-enco...

journal_title：Oncogene

authors： Haller BK,Bråve A,Wallgard E,Roswall P,Sunkari VG,Mattson U,Hallengärd D,Catrina SB,Hellström M,Pietras K

更新日期：2010-07-29 00:00:00

abstract：:Abundant data support a key role for the transcription factor nuclear factor-kappaB (NF-kappaB) signaling pathway in controlling the initiation and progression of human cancer. NF-kappaB and associated regulatory proteins such as IkappaB kinase (IKK) are activated downstream of many oncoproteins and there is much evid...

journal_title：Oncogene

authors： Bassères DS,Baldwin AS

更新日期：2006-10-30 00:00:00

abstract：:We have isolated a gene (WS5) that is specifically expressed at the mRNA and protein level in avian fibroblasts transformed by the v-myc oncogene of avian acute leukemia virus MC29. In a conditional cell transformation system, WS5 gene expression was tightly correlated with v-myc activation. The WS5 gene contains 11 e...

journal_title：Oncogene

authors： Reiter F,Hartl M,Karagiannidis AI,Bister K

更新日期：2007-03-15 00:00:00

abstract：:Tumor suppressor p53 has been shown to repress expression of vascular endothelial growth factor (VEGF), an endothelial cell-specific mitogen and a key mediator of tumor angiogenesis. The p63 gene, recently identified as a p53-relative, encodes multiple isoforms with structural and functional similarities and differenc...

journal_title：Oncogene

authors： Senoo M,Matsumura Y,Habu S

更新日期：2002-04-11 00:00:00

abstract：:The p53 tumour suppressor is involved in several crucial cellular functions including cell-cycle arrest and apoptosis. p53 stabilization occurs under hypoxic and DNA damage conditions. However, only in the latter scenario is stabilized p53 capable of inducing the expression of its pro-apoptotic targets. Here we presen...

journal_title：Oncogene

authors： Xenaki G,Ontikatze T,Rajendran R,Stratford IJ,Dive C,Krstic-Demonacos M,Demonacos C

更新日期：2008-10-02 00:00:00

abstract：:Studies have reported that interactions between keratins (KRTs) and other proteins initiate signaling cascades that regulate cell migration, invasion, and metastasis. In the current study, we found that expression of KRT19 was specifically high in breast cancers and significantly correlated with their invasiveness. Mo...

journal_title：Oncogene

authors： Saha SK,Choi HY,Kim BW,Dayem AA,Yang GM,Kim KS,Yin YF,Cho SG

更新日期：2017-01-19 00:00:00

abstract：:Recently, we have cloned and characterized the Ras association domain family 1A gene (RASSF1A) at 3p21.3, from which loss of genetic material is one of the most frequent events in several types of human solid tumors. The CpG island promoter region of this gene is highly methylated in several human cancers, most notabl...

journal_title：Oncogene

authors： Liu L,Yoon JH,Dammann R,Pfeifer GP

更新日期：2002-10-03 00:00:00

abstract：:SCL, GATA-1, GATA-2 and GATA-3 encode lineage restricted haemopoietic transcription factors. We have previously shown that SCL, GATA-1 and GATA-2 are expressed in multipotent progenitors prior to lineage commitment, but are down-regulated during granulocyte/monocyte differentiation. The phenomenon of gene extinction i...

journal_title：Oncogene

authors： Murrell AM,Green AR

更新日期：1995-02-16 00:00:00

abstract：:The IGF2 gene, which encodes a growth factor, is subject to genomic imprinting. The frequently observed loss of IGF2 imprinting in a variety of tumors has been suggested to contribute to neoplasia. Since these reports have not documented the imprinting status of IGF2 at the cellular level, it cannot be excluded that t...

journal_title：Oncogene

authors： He L,Cui H,Walsh C,Mattsson R,Lin W,Anneren G,Pfeifer-Ohlsson S,Ohlsson R

更新日期：1998-01-08 00:00:00

abstract：:The role of p53 in genotoxic therapy-induced metabolic shift in cancers is not yet known. In this study, we investigated the role of p53 in the glycolytic shift in head and neck squamous cell carcinoma cell lines following irradiation. Isogenic p53-null radioresistant cancer cells established through cumulative irradi...

journal_title：Oncogene

authors： Chang HW,Kim MR,Lee HJ,Lee HM,Kim GC,Lee YS,Nam HY,Lee M,Jang HJ,Lee KE,Lee JC,Byun Y,Kim SW,Kim SY

更新日期：2019-05-01 00:00:00

abstract：:Human basal-like breast cancer (BLBC) is an enigmatic and aggressive malignancy with a poor prognosis. There is an urgent need to identify therapeutic targets for BLBC, because current treatment modalities are limited and not effective. The forkhead box transcription factor FOXC1 has recently been identified as a crit...

journal_title：Oncogene

authors： Wang J,Ray PS,Sim MS,Zhou XZ,Lu KP,Lee AV,Lin X,Bagaria SP,Giuliano AE,Cui X

更新日期：2012-11-08 00:00:00

abstract：:Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1 expression leads to major changes in effectors of the dynamics of the actin cytoskeleton and the adhesion processes with a shift from cell-to-cell to cell-matrix...

journal_title：Oncogene

authors： Franzetti GA,Laud-Duval K,van der Ent W,Brisac A,Irondelle M,Aubert S,Dirksen U,Bouvier C,de Pinieux G,Snaar-Jagalska E,Chavrier P,Delattre O

更新日期：2017-06-22 00:00:00

abstract：:cDNA clones of the ski-related gene, sno, were isolated from a chicken cDNA library and sequenced. In contrast to the human system, from which two forms of sno cDNAs have been isolated, we obtained only one type of chicken sno cDNA, that encoding snoN. The coding region for chicken snoN was inserted into the retrovira...

journal_title：Oncogene

authors： Boyer PL,Colmenares C,Stavnezer E,Hughes SH

更新日期：1993-02-01 00:00:00

abstract：:The past three decades have seen an unremitting quest to identify and understand gastrointestinal stem cells, their plasticity in differentiating across cell types, as well as their role in normal, regenerative, and cancer cells. A fascinating hallmark of stem cells is their ability to undergo assymetric cell division...

journal_title：Oncogene

authors： Mishra L,Shetty K,Tang Y,Stuart A,Byers SW

更新日期：2005-08-29 00:00:00

abstract：:The MT-2 cell-line, which had been established through in vitro cell to cell transmission of human T-cell leukemia virus type I (HTLV-I) among human primary lymphocytes, was shown to possess multiple copies of integrated proviruses, including defective proviral genomes. By analysing a genomic clone, we identified the ...

journal_title：Oncogene

authors： Kubota S,Siomi H,Hatanaka M,Pomerantz RJ

更新日期：1996-04-04 00:00:00

abstract：:TNFα is a pleiotropic cytokine which fuels tumor cell growth, invasion, and metastasis in some malignancies, while in others it induces cytotoxic cell death. However, the molecular mechanism by which TNFα exerts its diverse effects on breast cancer subtypes remains elusive. Using in vitro assays and mouse xenografts, ...

journal_title：Oncogene

authors： Lee E,Ouzounova M,Piranlioglu R,Ma MT,Guzel M,Marasco D,Chadli A,Gestwicki JE,Cowell JK,Wicha MS,Hassan KA,Korkaya H

更新日期：2019-01-01 00:00:00

abstract：:There is increasing evidence that mast cells (MCs) and their mediators are involved in the remodeling of the tumor microenvironment and promote tumor growth, angiogenesis and metastasis. We have found that an increased density of MCs in thyroid cancer (TC) correlates with enhanced invasiveness. However, the MC-derived...

journal_title：Oncogene

authors： Visciano C,Liotti F,Prevete N,Cali' G,Franco R,Collina F,de Paulis A,Marone G,Santoro M,Melillo RM

更新日期：2015-10-01 00:00:00

abstract：:Prostate cancer (PCa) growth is dependent on androgens and on the androgen receptor (AR), which acts by modulating gene transcription. Tetratricopeptide repeat (TPR) proteins (FKBP52, FKBP51 and Cyp40) interact with AR in PCa cells, suggesting roles in AR-mediated gene transcription and cell growth. We report here tha...

journal_title：Oncogene

authors： Periyasamy S,Hinds T Jr,Shemshedini L,Shou W,Sanchez ER

更新日期：2010-03-18 00:00:00

abstract：:We evaluated the effect of nitric oxide (NO) on vascular endothelial growth factor (VEGF) gene expression in human A-172 glioblastoma cells and human HepG2 hepatocellular carcinoma cells. The mRNA level of VEGF increased in response to S-Nitroso-N-acetyl-D,L-penicillamine (SNAP) in both cell lines, and increased in mR...

journal_title：Oncogene

authors： Chin K,Kurashima Y,Ogura T,Tajiri H,Yoshida S,Esumi H

更新日期：1997-07-24 00:00:00

abstract：:The phosphatidylinositol 3'-kinase (PI3K) pathway is dysregulated in multiple myeloma (MM); we therefore tested a highly selective class I PI3K inhibitor, GDC-0941, for anti-myeloma activity. Functional and mechanistic studies were first performed in MM cell lines, then extended to primary MM patient samples cultured ...

journal_title：Oncogene

authors： Munugalavadla V,Mariathasan S,Slaga D,Du C,Berry L,Del Rosario G,Yan Y,Boe M,Sun L,Friedman LS,Chesi M,Leif Bergsagel P,Ebens A

更新日期：2014-01-16 00:00:00

abstract：:Tumors consistently mimic wound-generating chronic inflammation; however, why they do not heal like wounds with fibrotic scars remains unknown. The components of the tumor microenvironment, such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGFs), may account for this phenomenon. Tumor formati...

journal_title：Oncogene

authors： Zhang HR,Wang XD,Yang X,Chen D,Hao J,Cao R,Wu XZ

更新日期：2017-07-06 00:00:00

abstract：:A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Oncogene

authors： Wagner S,Vlachogiannis G,De Haven Brandon A,Valenti M,Box G,Jenkins L,Mancusi C,Self A,Manodoro F,Assiotis I,Robinson P,Chauhan R,Rust AG,Matthews N,Eason K,Khan K,Starling N,Cunningham D,Sadanandam A,Isacke CM,Ki

更新日期：2019-07-01 00:00:00

abstract：:Identification of prostate cancers at high risk of progression is difficult and a better understanding of how peptide growth factors influence cellular function might be useful. Fibroblast growth factors (FGFs) have been implicated in prostate cancer development. FGF8 was identified in the Shionogi mouse mammary carci...

journal_title：Oncogene

authors： Dorkin TJ,Robinson MC,Marsh C,Bjartell A,Neal DE,Leung HY

更新日期：1999-04-29 00:00:00

abstract：:In chronic myelogenous leukemia, the constitutive activation of the BCR-ABL kinase transforms cells to an addicted state that requires glucose metabolism for survival. We investigated S6K1, a protein kinase that drives glycolysis in leukemia cells, as a target for counteracting glucose-dependent survival induced by BC...

journal_title：Oncogene

authors： Barger JF,Gallo CA,Tandon P,Liu H,Sullivan A,Grimes HL,Plas DR

更新日期：2013-01-24 00:00:00

abstract：:The RNA-binding motif (RRM) gene on Y chromosome (RBMY), encoding a male germ cell-specific RNA-binding protein associated with spermatogenesis, was found inserted by hepatitis B virus (HBV) DNA in one childhood hepatocellular carcinoma (HCC). This study is aimed to explore the oncogenic potential of the RBMY protein....

journal_title：Oncogene

authors： Tsuei DJ,Hsu HC,Lee PH,Jeng YM,Pu YS,Chen CN,Lee YC,Chou WC,Chang CJ,Ni YH,Chang MH

更新日期：2004-07-29 00:00:00

abstract：:Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism as a component of the replication and repair machinery. This toroidal-shaped protein encircles DNA and can slide bidirectionally along the duplex. One of the well-established functions for PCNA is its role as the processivity ...

journal_title：Oncogene

authors： Kelman Z

更新日期：1997-02-13 00:00:00