Abstract:
:Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart disease, less is known as to whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Left ventricular systolic and diastolic dysfunction, left ventricular hypertrophy, and alterations in the coronary microcirculation have all been observed, although not consistently, in diabetic cardiomyopathy and are not fully explained by the cellular effects of hyperglycemia alone. The recent recognition that diabetes involves more than abnormal glucose homeostasis provides important new opportunities to examine and understand the impact of complex metabolic disturbances on cardiac structure and function.
journal_name
Circ Resjournal_title
Circulation researchauthors
Poornima IG,Parikh P,Shannon RPdoi
10.1161/01.RES.0000207406.94146.c2subject
Has Abstractpub_date
2006-03-17 00:00:00pages
596-605issue
5eissn
0009-7330issn
1524-4571pii
98/5/596journal_volume
98pub_type
杂志文章,评审abstract::The effects of acute hypoxemia and hypercapnic acidosis were examined in five unanesthetized dogs in which sodium intake was controlled at 80 mEq/24 hours for 4 days prior to study. Each animal was studied during combined acute hypoxemia and hypercapnic acidosis (Pao2 = 36 +/- 1 mm Hg, Paco2 = 52 +/- 1 mm Hg, pH = 7.1...
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journal_title:Circulation research
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.72.2.424
更新日期:1993-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
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更新日期:2000-06-23 00:00:00
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journal_title:Circulation research
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doi:10.1161/01.res.65.4.1094
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1161/01.res.36.6.799
更新日期:1975-06-01 00:00:00
abstract::In studies that attempt to measure intracellular calcium [( Ca2+]i) in the intact heart with the calcium indicator indo 1-AM, a fundamental assumption is that the signals report changes in myocyte [Ca2+]i. We studied isolated perfused rabbit hearts loaded with the calcium probe indo 1-AM and recorded surface fluoresce...
journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1990-08-01 00:00:00
abstract::Modulation of the inward Na+ current (I(Na)) by protein kinase C (PKC) was investigated by intracellular perfusion of a peptide corresponding to the catalytic subunit of PKC (PKCP). The effects of PKC activation independent of membrane-receptor pathways were studied in neonatal rat ventricular myocytes using whole-cel...
journal_title:Circulation research
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更新日期:1997-09-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.56.2.231
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.64.4.665
更新日期:1989-04-01 00:00:00
abstract::Changes in the behavior of the sarcoplasmic reticulum (SR) in rat ventricular myocytes were investigated under conditions of metabolic inhibition using laser-scanning confocal microscopy to measure intracellular Ca(2+) and the perforated patch-clamp technique to measure SR Ca(2+) content. Metabolic inhibition had seve...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.88.2.181
更新日期:2001-02-02 00:00:00
abstract:RATIONALE:Inhibition of glycogen synthase kinase-3 (GSK-3) protects the heart during ischemia/reperfusion (I/R), yet the underlying mechanisms of cardioprotection afforded by beta isoform-specific inhibition GSK-3 remain to be elucidated. OBJECTIVE:We studied the molecular mechanism mediating the effect of GSK-3β acti...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.111.249532
更新日期:2011-08-19 00:00:00
abstract::It is known that branching strands of cardiac tissue can form a substrate for very slow conduction. The branches slow conduction by acting as current loads drawing depolarizing current from the main strand ("pull" effect). It has been suggested that, upon depolarization of the branches, they become current sources rei...
journal_title:Circulation research
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更新日期:2001-10-26 00:00:00
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abstract::The role of Ca(2+)-dependent potassium channels in mediating vascular responses to activation of adenylate cyclase in vivo is not known. The goal of this study was to examine the hypothesis that dilatation of cerebral arterioles in response to activation of adenylate cyclase is mediated by activation of Ca(2+)-depende...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.76.6.1057
更新日期:1995-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1996-04-01 00:00:00
abstract::Lipid rafts are discrete membrane subdomains rich in sphingolipids and cholesterol. In ventricular myocytes a function of caveolae, a type of lipid rafts, is to concentrate in close proximity several proteins of the beta-adrenergic transduction pathway. We have investigated the subcellular localization of HCN4 channel...
journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2004-05-28 00:00:00
abstract::Recent studies have suggested a proangiogenic effect of angiotensin-converting enzyme (ACE) inhibition. We hypothesized that such a proangiogenic effect of ACE inhibition may be mediated, in part, by bradykinin (BK) B(2)-receptor pathway. This study therefore examined the neovascularization induced by ACE inhibitor tr...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/hh2001.097691
更新日期:2001-10-12 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1975-02-01 00:00:00
abstract::Cardiovascular disease is a major killer in postmenopausal women in the industrialized societies. To investigate the effect of progestogen and 17 beta-estradiol replacement therapy on atherogenesis, we studied 60 cholesterol-fed ovariectomized rabbits for 13 weeks. They were randomly assigned to four groups of 15 rabb...
journal_title:Circulation research
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更新日期:1992-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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abstract::Recent studies from our laboratory involving syncytial preparations have delineated electrophysiological distinctions between epicardium, endocardium, and a unique population of cells in the deep subepicardial to midmyocardial layers (M region) of the canine ventricle. In the present study, we used standard microelect...
journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00