RNA interference in embryonic stem cells and the prospects for future therapies.

Abstract:

:In 1998, two distinct and exciting scientific fields emerged which have profoundly shaped the current direction of biomedical research. The discovery of RNA interference (RNAi) and the derivation of human embryonic stem (ES) cells have yielded exciting new possibilities for researchers and clinicians alike. While fundamentally different, aspects from these two fields may be combined to yield extraordinary scientific and medical benefits. Here, we review the prospects of combining RNAi and ES cell manipulation for both basic research and future therapies, as well as current limitations and obstacles that need to be overcome.

journal_name

Gene Ther

journal_title

Gene therapy

authors

Heidersbach A,Gaspar-Maia A,McManus MT,Ramalho-Santos M

doi

10.1038/sj.gt.3302723

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

478-86

issue

6

eissn

0969-7128

issn

1476-5462

pii

3302723

journal_volume

13

pub_type

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